Patents by Inventor Jurgen GROLL

Jurgen GROLL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240132818
    Abstract: A device for fabricating a perfusable three-dimensional tissue construct includes a chamber in which the tissue construct may be cultivated, the chamber including an inlet and an outlet for perfusing the tissue construct, and a sacrificial scaffold fixed in the chamber. The sacrificial scaffold includes a thermo-responsive polymer, the thermo-responsive polymer being not dissolvable in water at human body temperature and becoming dissolvable in water at a temperature below 30° C. The sacrificial scaffold includes at least one filament extending from the inlet to the outlet such that dissolution of the sacrificial scaffold provides for a liquid channel from the inlet to the outlet. The sacrificial scaffold seals the inlet and/or the outlet such that dissolution of the sacrificial scaffold after receiving a cultivation matrix in the chamber provides for a liquid channel from the inlet to the outlet through the cultivation matrix. Methods of use and manufacture are also disclosed.
    Type: Application
    Filed: April 5, 2022
    Publication date: April 25, 2024
    Inventors: Jürgen Groll, Matthias Ryma
  • Patent number: 10105414
    Abstract: The present invention relates to a pharmaceutical composition comprising a (poly)peptide which comprises or consists of QEP or a QEP derivative thereof a nucleic acid molecule encoding said (poly)peptide or a vector comprising said nucleic acid molecule, for use in the prevention or in the treatment of a disease or disorder caused by, physiologically linked to or associated with glucose and/or galactose uptake, wherein said pharmaceutical composition is to be administered under a high-sugar condition. Furthermore, the pharmaceutical composition of the invention is for use in increasing insulin sensitivity. The invention further relates to a food composition comprising said (poly)peptide. The invention further relates to a method of screening for and/or identifying a compound suitable to prevent or treat said disease or disorder under a high-sugar condition.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: October 23, 2018
    Assignee: Julius-Maximilians-Universität Würzburg
    Inventors: Alexandra Friedrich, Jürgen Groll, Hermann Koepsell, Maike Veyhl-Wichmann
  • Publication number: 20170042969
    Abstract: The present invention relates to a pharmaceutical composition comprising a (poly)peptide which comprises or consists of QEP or a QEP derivative thereof a nucleic acid molecule encoding said (poly)peptide or a vector comprising said nucleic acid molecule, for use in the prevention or in the treatment of a disease or disorder caused by, physiologically linked to or associated with glucose and/or galactose uptake, wherein said pharmaceutical composition is to be administered under a high-sugar condition. Furthermore, the pharmaceutical composition of the invention is for use in increasing insulin sensitivity. The invention further relates to a food composition comprising said (poly)peptide. The invention further relates to a method of screening for and/or identifying a compound suitable to prevent or treat said disease or disorder under a high-sugar condition.
    Type: Application
    Filed: April 23, 2015
    Publication date: February 16, 2017
    Inventors: Alexandra FRIEDRICH, Jürgen GROLL, Hermann KOEPSELL, Maike VEYHL-WICHMANN
  • Patent number: 8816000
    Abstract: The invention relates to coatings having a contact angle hysteresis with water measured by the sessile drop method of at most 20°.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: August 26, 2014
    Assignee: Henkel AG & Co. KGaA
    Inventors: Haitao Rong, Peter Greiwe, Jürgen Groll, Christine Mohr, Marina Glesius, Martin Möller
  • Patent number: 8750988
    Abstract: A cochlear implant electrode includes an implantable electrode carrier having an outer surface with electrode contacts for electrically stimulating nerve tissue of the inner ear of a patient. A drug lumen is within the electrode carrier and adapted to receive a therapeutic fluid. The drug lumen contains delivery openings to the outer surface of the electrode carrier and a hydrogel matrix disposed between the drug lumen and the one or more delivery openings and adapted to swell in volume when exposed to the therapeutic fluid. The hydrogel matrix is adapted to control diffusion of the therapeutic fluid from the drug lumen through the delivery openings to the outer surface of the electrode carrier.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: June 10, 2014
    Assignee: MED-EL Elektromedizinische Geraete GmbH
    Inventors: Claude Jolly, Roland Hessler, Anandhan Dhanasingh, Jürgen Groll
  • Patent number: 8465968
    Abstract: The present invention relates to a label-free biosensor system, a method for manufacturing said label-free biosensor system, its use for detecting biochemical reactions and/or bindings, enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and protein-ligand interactions, as well as an assay method for detecting and/or quantifying an analyte of interest in a biological sample which comprises detecting the Recognition Induced Birefringence (RIB) generated in the presence as opposed to the absence of said analyte by bringing said sample into contact with said label-free biosensor system.
    Type: Grant
    Filed: December 22, 2009
    Date of Patent: June 18, 2013
    Assignee: DWI an der RWTH Aachen e.V.
    Inventors: Jürgen Groll, Martin Möller, Matthias Eberhardt
  • Patent number: 7998919
    Abstract: The invention relates to compositions for treating a hard surface, in particular for cleaning and/or dirt-repellent treatment of a hard surface, containing a) at least one multi-armed silyl polyalkoxylate of the formula (I) (H-A)n-Z-[A-B—Si(OR1)r(R2)3?r]m (I), where Z is a (m+n)=valent radical having at least three carbon atoms, A is a divalent polyoxyalkylene radical, wherein the m+n polyoxyalkylene radicals bound to Z can be different from one another, and wherein one radical A is in each case bound to Z via an oxygen atom belonging to Z, and one oxygen atom belonging to A is bound to B or hydrogen, B is a chemical bond or a divalent organic radical having 1 to 50 carbon atoms, OR1 is a hydrolysable group, R1 and R2 independently of one another are a linear or branched alkyl group having 1 to 6 carbon atoms and r is an integer from 1 to 3, and m is an integer ?1 and n is 0 or an integer ?1, and m+n has a value from 3 to 100, b) at least one surfactant, c) water and/or at least one nonaqueous solvent, d) if
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: August 16, 2011
    Assignee: Henkel AG & Co. KGaA
    Inventors: Haitao Rong, Stefan Stumpe, Matthias Lüken, Mirko Weide, Jürgen Groll, Peter Greiwe
  • Publication number: 20100209613
    Abstract: The invention relates to coatings having a contact angle hysteresis with water measured by the sessile drop method of at most 20°.
    Type: Application
    Filed: February 22, 2010
    Publication date: August 19, 2010
    Inventors: Haitao Rong, Peter Grejwe, Jürgen Groll, Christine Mohr, Marina Glesius, Martin Möller
  • Publication number: 20100209612
    Abstract: The invention relates to coatings with a contact angle hysteresis in water as measured by the tilting plate method of at most 20° made from silyl-terminated linear prepolymers which may cross-link with the surface of the substrate for coating, wherein the silyl-terminated linear prepolymers may be obtained by reaction of compounds of general formula (I): X-A-X? (I), where A=a polyoxyalkylene chain of ethylene oxide units or ethylene oxide and propylene oxide units with a maximum fraction of 50 wt.
    Type: Application
    Filed: February 19, 2010
    Publication date: August 19, 2010
    Inventors: Haitao Rong, Peter Grejwe, Jürgen Groll, Christine Mohr, Marina Glesius, Martin Möller
  • Publication number: 20100167263
    Abstract: The present invention relates to a label-free biosensor system, a method for manufacturing said label-free biosensor system, its use for detecting biochemical reactions and/or bindings, enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and protein-ligand interactions, as well as an assay method for detecting and/or quantifying an analyte of interest in a biological sample which comprises detecting the Recognition Induced Birefringence (RIB) generated in the presence as opposed to the absence of said analyte by bringing said sample into contact with said label-free biosensor system.
    Type: Application
    Filed: December 22, 2009
    Publication date: July 1, 2010
    Applicant: DWI an der RWTH Aachen e.V.
    Inventors: Jürgen GROLL, Martin Möller, Matthias Eberhardt
  • Publication number: 20100121422
    Abstract: A cochlear implant electrode includes an implantable electrode carrier having an outer surface with electrode contacts for electrically stimulating nerve tissue of the inner ear of a patient. A drug lumen is within the electrode carrier and adapted to receive a therapeutic fluid. The drug lumen contains delivery openings to the outer surface of the electrode carrier and a hydrogel matrix disposed between the drug lumen and the one or more delivery openings and adapted to swell in volume when exposed to the therapeutic fluid. The hydrogel matrix is adapted to control diffusion of the therapeutic fluid from the drug lumen through the delivery openings to the outer surface of the electrode carrier.
    Type: Application
    Filed: November 9, 2009
    Publication date: May 13, 2010
    Applicant: MED-EL ELEKTROMEDIZINISCHE GERAETE GMBH
    Inventors: Claude Jolly, Roland Hessler, Anandhan Dhanasingh, Jürgen Groll
  • Publication number: 20100056415
    Abstract: The invention relates to compositions for treating a hard surface, in particular for cleaning and/or dirt-repellent treatment of a hard surface, containing a) at least one multi-armed silyl polyalkoxylate of the formula (I) (H-A)n-Z-[A-B—Si(OR1)r(R2)3?r]m (I), where Z is a (m+n)=valent radical having at least three carbon atoms, A is a divalent polyoxyalkylene radical, wherein the m+n polyoxyalkylene radicals bound to Z can be different from one another, and wherein one radical A is in each case bound to Z via an oxygen atom belonging to Z, and one oxygen atom belonging to A is bound to B or hydrogen, B is a chemical bond or a divalent organic radical having 1 to 50 carbon atoms, OR1 is a hydrolysable group, R1 and R2 independently of one another are a linear or branched alkyl group having 1 to 6 carbon atoms and r is an integer from 1 to 3, and m is an integer ?1 and n is 0 or an integer ?1, and m+n has a value from 3 to 100, b) at least one surfactant, c) water and/or at least one nonaqueous solvent, d) if
    Type: Application
    Filed: December 4, 2007
    Publication date: March 4, 2010
    Applicant: Henkel G & Co. KGaA
    Inventors: Haitao Rong, Stefan Stumpe, Matthias Lüken, Mirko Weide, Jürgen Groll, Peter Greiwe
  • Publication number: 20090029043
    Abstract: The present invention relates to coatings that possess a dynamic contact angle hysteresis in water, measured by means of a Wilhelmy balance according to DIN EN 14370, of at most 15°, and are can be manufactured from star-shaped prepolymers and/or star-shaped prepolymer-nanoparticle complexes that are cross-linkable with one another and with the surface of the substrate to be coated, the star-shaped prepolymers and/or star-shaped prepolymer-nanoparticle complexes possessing, before being cross-linked, at least three hydrophilic polymer arms that, considered of themselves, are soluble in water, and that carry on all or on some of their free ends R1 silyl terminal groups of the following general formula (I): R1 is —CRa2—Si(ORb)r(Rc)3-r, where Ra denotes hydrogen or a linear or branched alkyl group having 1 to 6 carbon atoms, ORb denotes a hydrolyzable group, Rc denotes a linear or branched alkyl group having 1 to 6 carbon atoms, and r denotes a number from 1 to 3, and that carry, on the optionally present ends n
    Type: Application
    Filed: August 20, 2008
    Publication date: January 29, 2009
    Inventors: Haitao RONG, Jurgen GROLL, Peter GREIWE, Gallus SCHECHNER, Christine MOHR, Martin MOLLER