Abstract: The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Abstract: The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.

Abstract: A process for aftertreatment of polyol esters prepared by reacting polyols of the general formula H—(—O—[—CR1R2—]m—)o—OH in which R1 and R2 are each independently hydrogen, an alkyl radical having 1 to 5 carbon atoms, or a hydroxyalkyl radical having 1 to 5 carbon atoms, m is an integer of 1 to 10, o is an integer of 2 to 15, with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms in the presence of an adsorbent and in the presence of metal compounds selected from the group of titanium compounds, zirconium compounds, tin compounds, zinc compounds, iron compounds and aluminum compounds as a catalyst while removing the water formed and subsequently treating with steam, characterized in that the polyol ester obtained is aftertreated first with an oxidizing or reducing compound and immediately thereafter with steam at a temperature of 150 to 250° C. and over a period of 0.5 to 5 hours.

Abstract: The present invention relates to a process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms by partial recycling of the aliphatic monocarboxylic acid removed into the esterification reaction or into subsequent esterification batches.

Abstract: A process for aftertreatment of polyol esters prepared by reacting polyols of the general formula H—(—O—[—CR1R2—]m—)o—OH in which R1 and R2 are each independently hydrogen, an alkyl radical having 1 to 5 carbon atoms, or a hydroxyalkyl radical having 1 to 5 carbon atoms, m is an integer of 1 to 10, o is an integer of 2 to 15, with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms in the presence of an adsorbent and in the presence of metal compounds selected from the group of titanium compounds, zirconium compounds, tin compounds, zinc compounds, iron compounds and aluminium compounds as a catalyst while removing the water formed and subsequently treating with steam, characterized in that the polyol ester obtained is aftertreated first with an oxidizing or reducing compound and immediately thereafter with steam at a temperature of 150 to 250° C. and over a period of 0.5 to 5 hours.

Abstract: The present invention relates to a process for preparing polyol esters by reacting polyols with linear or branched aliphatic monocarboxylic acids having 3 to 20 carbon atoms by partial recycling of the aliphatic monocarboxylic acid removed into the esterification reaction or into subsequent esterification batches.

Abstract: The prow of the ship with a lower power requirement in open and ice-covered water has a front surface which is forwardly inclined at the top over the entire beam of the ship with marginal cutting edges, preferably on rod-like profiles. The front surface passes into an underwater prow part with frames which are V-shaped at the bottom. The cutting edges above the waterline can forwardly pass into two catamaran-like stems, the front surface being curved in the longitudinal direction. The front surface is carried by thwartships frames, which are horizontal at the bottom in the central part of its longitudinal extension, below the construction waterline and approximately forms a plane there. In the midships longitudinal direction an ice-cutting central skid is provided on the prow. Even in the case of widely varying ice characteristics, favorable conditions are provided for breaking out one-part ice floes.