Patents by Inventor Jurgen Seubert
Jurgen Seubert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5817862Abstract: The invention relates to a process for the preparation of cinnamic acid derivatives which involves reacting chlorinated aromatic compounds and acrylic acid derivatives in the presence of palladium catalysts.Type: GrantFiled: August 22, 1996Date of Patent: October 6, 1998Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Eike Poetsch, Volker Meyer, Ulrich Heywang, Rainer Christ, Jurgen Seubert
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Patent number: 5262556Abstract: The invention relates to a process for the reaction of fluorinated or chlorinated aromatics with electrophiles at the ortho position relative to the fluorine or chlorine atom, characterized in that a strong base is added to a mixture of the fluorinated or chlorinated aromatic and the electrophile.Type: GrantFiled: May 6, 1992Date of Patent: November 16, 1993Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Bernard Riefling, Jurgen Seubert, Volker Reiffenrath, Reinhard Hittich
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Patent number: 4699636Abstract: Liquid-crystalline materials can be outgassed by thermal treatment under reduced pressure in a thin-layer evaporator or with additional ultrasonic treatment.Type: GrantFiled: February 14, 1986Date of Patent: October 13, 1987Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Klaus Bofinger, Hans A. Kurmeier, Michael Romer, Jurgen Seubert
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Patent number: 4362875Abstract: Novel tetrahydroquinolines of the formula ##STR1## wherein R is cycloalkyl or cycloalkenyl each containing 4-7 ring carbon atoms and the cycloalkyl optionally being substituted by one of methyl, hydroxyl or oxo; phenyl substituted by 1-2 of amino, acylamino of up to 4 carbon atoms, Hal, hydroxyl, methoxy or nitro, wherein Hal is fluorine, chlorine, bromine or iodine; thienyl; pyridyl; tetrahydropyranyl; tetrahydrothiopyranyl; and when at least one of R.sup.2, R.sup.3, R.sup.4, R.sup.5 or R.sup.6 is other than H, also phenyl; R.sup.2, R.sup.3 and R.sup.4 each are H or methyl; R.sup.5 and R.sup.6 each are H, methyl or methoxy; R.sup.7 is H or --CO--CH.sub.Type: GrantFiled: December 6, 1978Date of Patent: December 7, 1982Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventor: Jurgen Seubert
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Patent number: 4196291Abstract: 2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof. This is a division, or application Ser. No. 742,133, filed on Nov. 15, 1976, which in turn is a divisional of Ser. No. 533,467, filed on Dec. 16, 1974, now U.S. Pat. No. 4,001,411.Type: GrantFiled: December 18, 1978Date of Patent: April 1, 1980Assignee: Merck Patent Gesellschaft mit beschraenkter HaftungInventors: Jurgen Seubert, Herbert Thomas, Peter Andrews
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Patent number: 4162314Abstract: Novel .beta.-lactam antibiotics are compounds of the formula: ##STR1## wherein R is alkyl of up to 6 carbon atoms or, when A is oxygen, R is hydrogen; A is oxygen or --OCO--; Z is ##STR2## R.sup.1 is hydrogen, acetoxy or S-Het; Het is 1,2,3-triazol-5-yl, 1-methyltetrazol-5-yl, 1,3,4-thiadiazol-2-yl or 2-methyl-1,3,4-thiadiazol-5-yl; and n is an integer from 0 to 8; or a readily-cleavable ester or physiologically-acceptable salt thereof.Type: GrantFiled: June 13, 1977Date of Patent: July 24, 1979Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rudolf Gottschlich, Rolf Gericke, Horst Juraszyk, Jurgen Seubert, Wighard Strehlow, Helmut Wahlig, Rolf Bergmann, Elvira Dingeldein
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Patent number: 4162319Abstract: Isoquinolines of the formula ##STR1## wherein R.sup.1 is H, OH, alkyl; R.sup.2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R.sup.3 is H, alkyl or hydroxy alkyl; R.sup.4 is H, alkyl or phenyl; R.sup.5 is O, H,H or H and alkyl, phenyl, halo or hydroxy; R.sup.6 and R.sup.7 are optional substituents; and R.sup.8 is H or alkyl, R.sup.2 being a thiocarbonyl or carbonyloxy group when R.sup.1 and R.sup.3 to R.sup.8 are H and X is O; and their physiologically acceptable salts, are antihelmintics, especially against cestodes and trematodes; some also possessing CNS activity, e.g., psychotropic and blood pressure regulating activity.Type: GrantFiled: August 7, 1978Date of Patent: July 24, 1979Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Jurgen Seubert, Rolf Pohlke, Herbert Thomas, Peter Andrews
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Patent number: 4141978Abstract: 2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof.Type: GrantFiled: November 15, 1976Date of Patent: February 27, 1979Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Jurgen Seubert, Herbert Thomas, Peter Andrews
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Patent number: 4120961Abstract: Isoquinolines of the formula ##STR1## wherein R.sup.1 is H, OH, alkyl; R.sup.2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R.sup.3 is H, alkyl or hydroxy alkyl; R.sup.4 is H, alkyl or phenyl; R.sup.5 is O, H,H or H and alkyl, phenyl, halo or hydroxy; R.sup.6 and R.sup.7 are optional substituents; and R.sup.8 is H or alkyl, R.sup.2 being a thiocarbonyl or carbonyloxy group when R.sup.1 and R.sup.3 to R.sup.8 are H and X is O; and their physiologically acceptable salts, are antihelmintics, especially against cestodes and trematodes; some also possessing CNS activity, e.g., psychotropic and blood pressure regulating activity.Type: GrantFiled: July 20, 1977Date of Patent: October 17, 1978Assignee: E. MerckInventors: Jurgen Seubert, Rolf Pohlke, Herbert Thomas, Peter Andrews
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Patent number: 4113867Abstract: 2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof.Type: GrantFiled: November 15, 1976Date of Patent: September 12, 1978Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Jurgen Seubert, Herbert Thomas, Peter Andrews
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Patent number: 4051243Abstract: Isoquinolines of the formula ##STR1## wherein R.sup.1 is H, OH, alkyl; R.sup.2 is H, or an unsubstituted or substituted carbonyl, carbonyloxy or thiocarbonyl group; R.sup.3 is H, alkyl or hydroxy alkyl; R.sup.4 is H, alkyl or phenyl; R.sup.5 is O, H,H or H and alkyl, phenyl, halo or hydroxy; R.sup.6 and R.sup.7 are optional substituents; and R.sup.8 is H or alkyl, R.sup.2 being a thiocarbonyl or carbonyloxy group when R.sup.1 and R.sup.3 to R.sup.8 are H and X is 0; and their physiologically acceptable salts, are antihelmintics, especially against cestodes and trematodes; some also possessing CNS activity, e.g., psychotropic and blood pressure regulating activity.Type: GrantFiled: August 26, 1975Date of Patent: September 27, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Jurgen Seubert, Rolf Pohlke, Herbert Thomas, Peter Andrews
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Patent number: 4024272Abstract: Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl, R.sup.5 is H, F, Cl, Br, CF.sub.3, OH, alkyl, alkoxy, NO.sub.2, NH.sub.2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO.sub.2, NH, N-alkyl or N-acyl, alkyl and alkoxy in each case being of 1-3 carbon atoms and acyl in each case being of 1-4 carbon atoms, with the proviso that when R.sup.5 is methoxy and X is a sulfur atom, R.sup.5 is in the 8- or 9-position only, and their physiologically acceptable acid addition salts, possess broad spectrum antibacterial activity, including tetracycline-resistant Gram-positive and Gram-negative organisms.Type: GrantFiled: August 26, 1975Date of Patent: May 17, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Rogalski, Richard Kirchlechner, Jurgen Seubert, Rudolf Gottschlich, Rosmarie Steinigeweg, Rolf Bergmann, Helmut Wahlig, Joachim Gante
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Patent number: 4001411Abstract: 2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof.Type: GrantFiled: December 16, 1974Date of Patent: January 4, 1977Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Jurgen Seubert, Herbert Thomas, Peter Andrews
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Patent number: 3993760Abstract: (-)-2-Benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is prepared by benzoylation of (-)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline, or cyclization of a compound of the formula ##SPC1##Wherein X is F, Cl, Br, I or O-tosyl and which has the optical configuration of the final product, or cyclization of a compound of the formula ##SPC2## wherein Y is OH, alkoxy, F, Cl, Br or I under HY-removing reaction conditions and which has the optical configuration of the final product, which is an anthelmintic.Type: GrantFiled: June 21, 1974Date of Patent: November 23, 1976Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Pohlke, Friedrich Loebich, Jurgen Seubert, Herbert Thomas, Peter Andrews