Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.

Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.

Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.

Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.

Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.

Abstract: The radially expandable prosthesis for implantation in a lumen comprises a tubular wall produced from sheet metal and showing cuts enabling the prosthesis to expand. By using water guided laser cutting technology to make these cuts and/or specific electrochemical polishing technology a more biocompatible prosthesis is obtained, causing less thrombogenicity and less foreign body reaction. By covering an intraluminal prosthesis with a titaniumnitride coating the biocompatibility of the prosthesis is improved. By applying perforating or non-perforating holes (4) and filling these holes with a therapeutic agent, the intraluminal prosthesis can be used to locally administer medicines, genes and or other substances to prevent in this way thrombotic occlusions and/or neointimal hyperplasia and prosthesis narrowing. Using this specific perforated prosthesis design the total drug capacity can be increased and also the drug release time prolongs significantly.

Abstract: A radially expandable prosthesis for implantation in a lumen comprises a tubular wall having an inner surface and an outer surface. The tubular wall is provided with cuts to form solid struts which have a thickness and which enables the prosthesis to expand. The solid struts have reservoirs made therethrough in the form of perforating holes for containing a therapeutic agent. The perforating holes each have an inner opening and an outer opening of substantially the same size. The prosthesis, including said perforating holes, has a smooth electrochemically polished surface.

Abstract: The radially expandable prosthesis for implantation in a lumen shows an inner and an outer surface and comprises a tubular wall composed of elongated struts (1, 2, 4) with a predetermined strut width. The struts are arranged to enable an expansion from a non-expanded state of the prosthesis to an expanded state. At least a number of the struts further show at least one location (5) provided with at least one hole (6) at the outer surface of the prosthesis. In order to maintain the required radial and fatigue strength of the prosthesis when providing the holes (6) without reducing the flexibility of the prosthesis and without increasing the additional amount of material therefor to a too large extend, the struts have at said locations an increased width (W2) larger than the predetermined width (W1) of the strut before and/or after said location (5).

Abstract: The radially expandable prosthesis for implantation in a lumen comprises a tubular wall produced from sheet metal and showing cuts enabling the prosthesis to expand. By using water guided laser cutting technology to make these cuts and/or specific electrochemical polishing technology a more biocompatible prosthesis is obtained, causing less thrombogenicity and less foreign body reaction. By covering an intraluminal prosthesis with a titaniumnitride coating the biocompatibility of the prosthesis is improved. By applying perforating or non-perforating holes (4) and filling these holes with a therapeutic agent, the intraluminal prosthesis can be used to locally administer medicines, genes and or other substances to prevent in this way thrombotic occlusions and/or neointimal hyperplasia and prosthesis narrowing. Using this specific perforated prosthesis design the total drug capacity can be increased and also the drug release time prolongs significantly.