Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g.

Abstract: The invention relates to the use of an inhibitor of formula (I), or a pharmaceutically acceptable salt thereof having an activity on protein kinases PKC alpha, PKC beta, PKC gamma, PKC epsilon, PKC theta, CDK-1, KDR, PKA, Flt-1, Flt-2, Flt-3 or Flt-4, or on a combination of the above enzymes, for the treatment and/or prevention of neurological and vascular disorders related to beta-amyloid generation and/or aggregation such as neurodegenerative diseases like Down's Syndrome, memory and cognitive impairment, dementia, amyloid neuropathies, brain inflammation, nerve and brain trauma, vascular amyloidosis, or cerebral hemorrhage with amyloidosis.

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: The present invention concerns protein kinase C (PKC) theta, in particular, the three-dimensional structure of the catalytic domain of PKC theta. Methods of expression, purification and crystallization of PKC theta catalytic domain are provided in preparation for crystallography. The atomic coordinates of a complex of PKC theta complexed with an inhibitor are also provided.

Abstract: Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g.

Abstract: Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g.

Abstract: Provided are compounds of formula I which are useful in the treatment or prevention of disorders or diseases mediated by T lymphocytes and/or PKC or GSK-3 BETA.

Abstract: A cover plate device for a heat exchanger device, especially for a vehicle heater, includes a receiving zone (14) intended to be arranged on the heat exchanger device and to receive a fluid stream leaving the heat exchanger device in a first direction of flow (S1), a mixing zone (22) for mixing the partial fluid streams (F1, F2, F3) leaving the heat exchanger device in different areas and entering the receiving zone (14), and at least two delivery zones (24, 26) for delivering the fluid stream leaving the mixing zone (22) from the cover plate device (10).

Abstract: The present invention relates to a separator for separating liquid components, in particular oil components, from a gas flow by means of a cyclone and a tank. The liquid separator has a cyclone 1 with a separating chamber 2 including gas supply 3 and gas discharge 4 and a tank 5 which is connected to the cyclone 1 via a connection opening 6 and is characterised in that the interior of the tank 5 is filled at least partially with a porous open-pore solid material 7 in order to interrupt the flow, dampen the flow, dampen the oscillations and/or discharge the liquid.

Abstract: A device for plane-parallel attachment of a first module to a sidewall of a second module includes at least one coupling element with clamping projections having beveled end sections. The coupling element includes a guide element with two opposing guide tabs, a locking element, and a stop element, wherein the guide tabs, the locking element, and the stop element abut sidewalls of the connecting element so that the two guide tabs extend from a first opposing pair of the sidewalls, and the locking element and the stop element extend from another opposing pair of the sidewalls perpendicular to the first pair. The first module includes an interlock for captivating the coupling element or elements in the sidewall of the first module, whereas the second module has a receiving part capable of receiving the coupling element or elements captivated in the sidewall of the first module.

Abstract: A heating system for a vehicle comprises a heating air fan for producing a heating air flow to be introduced into a vehicle interior, a heating device with a heat exchanger arrangement for heating the heating air flow delivered by the heating air fan, a vehicle interior temperature sensor arrangement for producing an output in connection with the temperature in the vehicle interior, a vehicle interior reference temperature presetting arrangement, a heating air flow temperature sensor arrangement for producing a second output in connection with the outlet temperature of the heating air flow heated by the heating device, and also a control device which is arranged so as to set the delivery capacity of the heating air fan in dependence on the first output and on the vehicle interior reference temperature predetermined by the vehicle interior reference temperature presetting arrangement, and to set the heating capacity of the heating device in dependence on the second output.

Abstract: Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g.

Abstract: The invention relates to immunoadsorbers for use in sepsis therapy, in particular for removal of complement factors and lipopolysaccharides (LPS) and, if need be, further sepsis mediators such as TNF and interleukins from body fluids, methods for their production and their use.

Abstract: A burner arrangement for a heating device, particularly a vehicle heating device, comprising a combustion chamber (18) and a flame tube (22) conducting the combustion products away from the combustion chamber (18), having an inlet region (28) near the combustion chamber (18) at which combustion products enter the flame tube (22) and an outlet region (36) at which combustion products leave the flame tube (22). At least one intermediate outlet region (42) between the inlet region (28) and the outlet region (36), in which intermediate outlet region (42) a portion of the combustion products can emerge from the flame tube (22).

Abstract: A burner arrangement for a heating device, particularly a vehicle heating device, comprising a combustion chamber (18) and a flame tube (22) conducting the combustion products away from the combustion chamber (18), having an inlet region (28) near the combustion chamber (18) at which combustion products enter the flame tube (22) and an outlet region (36) at which combustion products leave the flame tube (22). At least one intermediate outlet region (42) between the inlet region (28) and the outlet region (36), in which intermediate outlet region (42) a portion of the combustion products can emerge from the flame tube (22).

Abstract: A heating system for a vehicle comprises a heating air fan for producing a heating air flow to be introduced into a vehicle interior, a heating device with a heat exchanger arrangement for heating the heating air flow delivered by the heating air fan, a vehicle interior temperature sensor arrangement for producing an output in connection with the temperature in the vehicle interior, a vehicle interior reference temperature presetting arrangement, a heating air flow temperature sensor arrangement for producing a second output in connection with the outlet temperature of the heating air flow heated by the heating device, and also a control device which is arranged so as to set the delivery capacity of the heating air fan in dependence on the first output and on the vehicle interior reference temperature predetermined by the vehicle interior reference temperature presetting arrangement, and to set the heating capacity of the heating device in dependence on the second output.

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: A cover plate device for a heat exchanger device, especially for a vehicle heater, includes a receiving zone (14) intended to be arranged on the heat exchanger device and to receive a fluid stream leaving the heat exchanger device in a first direction of flow (S1), a mixing zone (22) for mixing the partial fluid streams (F1, F2, F3) leaving the heat exchanger device in different areas and entering the receiving zone (14), and at least two delivery zones (24, 26) for delivering the fluid stream leaving the mixing zone (22) from the cover plate device (10).