Abstract: Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a vaginal birth canal of a maternal pelvis, and include positioning a probe device in the maternal pelvis during active labor, transmitting and receiving a plurality of ultrasound (US) and photoacoustic (PA) signals between the probe device and fetal brain, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of venous and arterial blood flow of respective blood vessels in the fetal brain, measuring oxygen saturation of the respective venous and arterial blood vessels based on data from the one or more images, and estimating the oxygen measurement in the fetal brain during active labor based on the measured oxygen saturation.

Abstract: Compositions and methods for detection and assessment of galectins are provided by the present invention, including labeled compositions, pharmaceutical composition including a labeled composition for galectin detection and a pharmaceutically acceptable carrier, method of aiding in diagnosis and/or treatment of a condition characterized by upregulation of one or more galectins in a subject in need thereof and precursor compositions for synthesis of chemical compositions, including but not limited to labeled compositions for detection and assessment of galectins.

Abstract: Methods and systems are described for multispectral, non-invasive, and real-time assessment to diagnose hemorrhaging and/or hypoxia through PA imaging through an acoustic window defined in a body, such as through transfontanelle PA imaging of a neonatal infant brain. Such methods and systems include transmitting a plurality of ultrasound (US) waves and light between the probe device and the acoustic window, converting, via the probe device, a plurality of reflected US waves and generated PA waves into a plurality of US and PA signals, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of the brain or spinal cord through the acoustic window, such as the neonatal infant brain through the fontanelle, and diagnosing at least one of one or more hemorrhages and hypoxia in the neonatal infant brain at least partially based on the one or more images.

Abstract: Compositions and methods for detection and assessment of galectins are provided by the present invention, including a labeled compositions, pharmaceutical composition including a labeled composition for galectin detection and a pharmaceutically acceptable carrier, method of aiding in diagnosis and/or treatment of a condition characterized by upregulation of one or more galectins in a subject in need thereof and precursor compositions for synthesis of chemical compositions, including but not limited to labeled compositions for detection and assessment of galectins.

Abstract: Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a vaginal birth canal of a maternal pelvis, and include positioning a probe device in the maternal pelvis during active labor, transmitting and receiving a plurality of ultrasound (US) and photoacoustic (PA) signals between the probe device and fetal brain, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of venous and arterial blood flow of respective blood vessels in the fetal brain, measuring oxygen saturation of the respective venous and arterial blood vessels based on data from the one or more images, and estimating the oxygen measurement in the fetal brain during active labor based on the measured oxygen saturation.

Abstract: Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One example of a method is a method for detecting histone deacetylase activity comprising introducing a compound according to formula (I) to a plurality of cells and monitoring the cells with magnetic resonance spectroscopy.

Abstract: The disclosure includes a composition including a poly(L-glutamic acid) and a NIRF dye. It also includes a method including providing to a plurality of cells an imaging agent including poly(L-glutamic acid), a NIRF dye and then imaging the cells to detect the imaging agent. It further includes a dual functional contrast agent including an MRI agent conjugated with an optical imaging agent. A method of detecting cancer is provided including injecting a dual functional contrast agent into a patient and performing both an MRI and an optical scan. The presence of the agent may indicate cancer. A method of detecting cancer by injecting PG-DTPA-Gd-NIR813 into a patient, then detecting the presence or absence of Gd in a cell or tissue of the patient and detecting the presence or absence of NIR813 in a cell or tissue of the patient is provided. The presence of Gd and NIR813 may indicate cancer.

Abstract: Provided are compositions and methods for intracellular detection of enzyme activity. One example of a composition is a histone deacetylase substrate comprising a compound of the following formula (I): One example of a method is a method for detecting histone deacetylase activity comprising introducing a compound according to formula (1) to a plurality of cells and monitoring the cells with magnetic resonance spectroscopy.