Patents by Inventor Jurjus Jurayj
Jurjus Jurayj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9505792Abstract: Cidofovir is obtained in different forms, including amorphous cidofovir, crystalline anhydrous cidofovir, crystalline cidofovir monohydrate, and crystalline cidofovir dihydrate, including various polymorphs.Type: GrantFiled: March 4, 2015Date of Patent: November 29, 2016Assignee: Johnson Matthey Public Limited CompanyInventors: George Scott Wilson, Angela Barkley, Jurjus Jurayj
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Publication number: 20150175640Abstract: Cidofovir is obtained in different forms, including amorphous cidofovir, crystalline anhydrous cidofovir, crystalline cidofovir monohydrate, and crystalline cidofovir dihydrate, including various polymorphs.Type: ApplicationFiled: March 4, 2015Publication date: June 25, 2015Inventors: George Scott Wilson, Angela Barkley, Jurjus Jurayj
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Patent number: 8999958Abstract: Cidofovir is obtained in different forms, including amorphous cidofovir, crystalline anhydrous cidofovir, crystalline cidofovir monohydrate, and crystalline cidofovir dihydrate, including various polymorphs.Type: GrantFiled: April 6, 2012Date of Patent: April 7, 2015Assignee: Johnson Matthey Public Limited CompanyInventors: George Scott Wilson, Angela Barkley, Jurjus Jurayj
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Publication number: 20120277191Abstract: Cidofovir is obtained in different forms, including amorphous cidofovir, crystalline anhydrous cidofovir, crystalline cidofovir monohydrate, and crystalline cidofovir dihydrate, including various polymorphs.Type: ApplicationFiled: April 6, 2012Publication date: November 1, 2012Applicant: Johnson Matthey Public Limited CompanyInventors: George Scott Wilson, Angela Barkley, Jurjus Jurayj
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Publication number: 20060106236Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1-C6 alkyl groups; C7-C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6-C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1-C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.Type: ApplicationFiled: January 9, 2006Publication date: May 18, 2006Inventors: Derek Clissold, Stuart Craig, Rajendrakumar Gadikota, Min He, Jurjus Jurayj, Shahrokh Kazerani, Erwin Rannala, Pradeep Sharma
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Publication number: 20060106235Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1-C6 alkyl groups; C7-C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6-C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1-C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.Type: ApplicationFiled: January 9, 2006Publication date: May 18, 2006Inventors: Derek Clissold, Stuart Craig, Rajendrakumar Gadikota, Min He, Jurjus Jurayj, Shahrokh Kazerani, Erwin Rannala, Pradeep Sharma
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Publication number: 20050154220Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1-C6 alkyl groups; C7-C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6-C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1-C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.Type: ApplicationFiled: January 5, 2004Publication date: July 14, 2005Inventors: Derek Clissold, Stuart Craig, Rajendrakumar Gadikota, Min He, Jurjus Jurayj, Shahrokh Kazerani, Erwin Rannala, Pradeep Sharma
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Patent number: 6677459Abstract: Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: R1, R21, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. R2 is —NR4R5 or —N+≡C−. Alternatively, R1 and R2, taken together with the methine group to which they are bonded, are a moiety represented by the following structural formula: R3 is —NH2, —OH, —OC(O)H or —OR9. R5, R6 and R7 are independently —H or an amine protecting group. R8 is —H, —OH or —OR8. R9 is an alcohol protecting group. Also disclosed are methods of preparing these compounds.Type: GrantFiled: April 30, 2003Date of Patent: January 13, 2004Assignee: Johnson Matthey Pharmaceutical Materials, Inc.Inventors: Richard L. Gabriel, Jurjus Jurayj
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Publication number: 20030208083Abstract: Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: 1Type: ApplicationFiled: April 30, 2003Publication date: November 6, 2003Applicant: Johnson Matthey Pharmaceutical Materials, Inc.Inventors: Richard L. Gabriel, Jurjus Jurayj
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Patent number: 6590106Abstract: Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: R1, R2, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. R2 is —NR4R5 or —N+≡C−. Alternatively, R1, and R2, taken together with the methine group to which they are bonded, are a moiety represented by the following structural formula: R3 is —NH2, —OH, —OC(O)H or —OR9. R5, R6 and R7 are independently —H or an amine protecting group. R8 is —H, —OH or —OR8. R9 is an alcohol protecting group. Also disclosed are methods of preparing these compounds.Type: GrantFiled: June 21, 2002Date of Patent: July 8, 2003Assignee: Pharm-Eco Laboratories, Inc.Inventors: Richard L. Gabriel, Jurjus Jurayj
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Publication number: 20030040644Abstract: The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: 1Type: ApplicationFiled: July 3, 2002Publication date: February 27, 2003Applicant: Pharm-Eco Laboratories, Inc.Inventors: Richard L. Gabriel, Adel M. Moussa, Sharon Fitzhenry, Changhua Liu, David A. Swanson, Brittany Le, Salah Zahr, Yesh P. Sachdeva, Jurjus Jurayj
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Publication number: 20020188135Abstract: Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: 1Type: ApplicationFiled: June 21, 2002Publication date: December 12, 2002Applicant: Pharm-Eco Laboratories, Inc.Inventors: Richard L. Gabriel, Jurjus Jurayj
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Patent number: 6479669Abstract: Disclosed are novel compounds, and methods of making the same, represented by Structural Formula II, IX or XXVII: The compounds can be used to prepare combinatorial libraries based on a multicomponent Ugi reaction.Type: GrantFiled: June 29, 1999Date of Patent: November 12, 2002Assignee: Pharm-Eco Laboratories, Inc.Inventors: Richard L. Gabriel, Jurjus Jurayj
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Patent number: 6462221Abstract: The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: In Structural Formula I, R is an amine protecting group, and R1 is an amino acid side-chain, a protected amino acid side-chain, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted aralkyl or a substituted or unsubstituted heteroaralkyl group. The method involves contacting a 1-nitro-3-substituted-3-amino-2-propanone with a reducing agent to form a mixture of 1-nitro-3-substituted-3-amino-2-propanol diastereomers. The 1-nitro-3-substituted-3-amino-2-propanol diastereomers are then separated by simulated moving bed chromatography to obtain one or more 1-nitro-3-substituted-3-amino-2-propanol diastereomer.Type: GrantFiled: May 19, 2000Date of Patent: October 8, 2002Assignee: Pharm-Eco Laboratories, Inc.Inventors: Richard L. Gabriel, Adel M. Moussa, Sharon Fitzhenry, Changhua Liu, David A. Swanson, Brittany La, Salah Zahr, Yesh P. Sachdeva, Jurjus Jurayj
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Publication number: 20020010342Abstract: Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: 1Type: ApplicationFiled: June 29, 1999Publication date: January 24, 2002Inventors: RICHARD L. GABRIEL, JURJUS JURAYJ
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Patent number: 6268535Abstract: The present invention is a method of preparing a 3-aryl-1-indanamine represented by structural formula I: and physiologically acceptable salts thereof. In structure I, phenyl ring A can be unsubstituted or substituted with 1-4 substitutents. R1 is an aromatic group which can be substituted or unsubstituted. R2 and R3 are each, independently, hydrogen, an aliphantic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, an aralkyl group, or a substituted aralkyl group. Alternatively, R2 and R3, taken together with the nitrogen substitutent on the indan ring, form a non-aromatic ring system having 1-2 heteroatoms.Type: GrantFiled: January 7, 1999Date of Patent: July 31, 2001Assignee: Pharm-Eco Laboratories, Inc.Inventors: Adel M. Moussa, Reem Haider, Heather Taft, Jurjus Jurayj, Weiheng Wang, HaeSuk Suh
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Patent number: 5441941Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.Type: GrantFiled: December 21, 1993Date of Patent: August 15, 1995Assignees: The United States of America as represented by the Secretary of DHHS, Purdue Research FoundationInventors: Rudiger D. Haugwitz, Venkatachiala L. Narayanan, Mark Cushman, Jurjus Jurayj
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Patent number: 5272146Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.Type: GrantFiled: October 2, 1992Date of Patent: December 21, 1993Assignees: The United States of America as represented by the United States Department of Health and Human Services, Purdue Research FoundationInventors: Rudiger D. Haugwitz, Venkatachala L. Narayanan, Mark Cushman, Jurjus Jurayj