Patents by Inventor Jurke Kotthaus

Jurke Kotthaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds for the treatment of influenza
    Patent number: 9828333
    Abstract: The invention relates to oseltamivir derivatives as influenza neuraminidase inhibitors for treating influenza infections and to a method for producing said compounds.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: November 28, 2017
    Assignee: CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL
    Inventors: Bernd Clement, Joscha Kotthaus, Jurke Kotthaus, Dennis Schade
  • Orally bioavailable pentamidine prodrugs for the treatment of diseases
    Patent number: 9662308
    Abstract: The present invention relates to prodrug derivatives of pentamidine, their use in the treatment and/or prophylaxis of diseases such as tumor diseases, as well as leishmaniasis, trypanosomiasis, pneumocystis carinii pneumonia (PcP), and malaria.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: May 30, 2017
    Assignee: Dritte Patentportfolio Beteiligungsgesellschaft mbH & Co. KG
    Inventors: Bernd Clement, Joscha Kotthaus, Jürke Kotthaus, Dennis Schade
  • N-hydroxy-L-arginine derivatives for the treatment of diseases
    Patent number: 9387185
    Abstract: The present invention relates to physically-chemically and pharmacokinetically enhanced N?-hydroxy-L-arginine (NOHA) derivatives and a method for producing the NOHA derivatives having enhanced physical-chemical and pharmacokinetic properties according to the invention.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: July 12, 2016
    Assignee: Christian-Albrechts-Universität Zu Kiel
    Inventors: Bernd Clement, Dennis Schade, Jürke Kotthaus
  • ORALLY BIOAVAILABLE PENTAMIDINE PRODRUGS FOR THE TREATMENT OF DISEASES
    Publication number: 20150111965
    Abstract: The present invention relates to prodrug derivatives of pentamidine, their use in the treatment and/or prophylaxis of diseases such as tumor diseases, as well as leishmaniasis, trypanosomiasis, pneumocystis carinii pneumonia (PcP), and malaria.
    Type: Application
    Filed: December 23, 2014
    Publication date: April 23, 2015
    Inventors: Bernd CLEMENT, Joscha KOTTHAUS, Jürke KOTTHAUS, Dennis SCHADE
  • Inhibitors of dimethylarginine dimethylaminohydrolase
    Patent number: 8921421
    Abstract: The invention relates to an inhibitor of dimethylarginine dimethylaminohydrolase (DDAH) of general structural formula (I), wherein B is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromatic system having a ring size of 3 to 6; R1 is selected from the group of structures (i-vii), wherein R2, R3 and R4 are selected from the group consisting of hydrogen, an alkyl or aryl radical, R5 and R6 are selected from the group consisting of hydrogen, a hydrocarbon chain having a chain length of 1 to 8 and an aryl radical, R7, R8, R9 and R10 are selected from the group consisting of hydrogen, and alkyl or aryl radical; W is oxygen (O) or nitrogen (N); and X is a methylene group (CH2) or a secondary amino group (NH); Y is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromat
    Type: Grant
    Filed: December 8, 2009
    Date of Patent: December 30, 2014
    Assignee: Christian-Albrechts-Universitaet Zu Kiel
    Inventors: Bernd Clement, Jürke Kotthaus, Dennis Schade
  • COMPOUNDS FOR THE TREATMENT OF INFLUENZA
    Publication number: 20140288312
    Abstract: The invention relates to oseltamivir derivatives as influenza neuraminidase inhibitors for treating influenza infections and to a method for producing said compounds.
    Type: Application
    Filed: October 29, 2012
    Publication date: September 25, 2014
    Inventors: Bernd Clement, Joscha Kotthaus, Jurke Kotthaus, Dennis Schade
  • Nª -Hydroxy-L-Arginine Derivatives for the Treatment of Diseases
    Publication number: 20120123111
    Abstract: The present invention relates to physically-chemically and pharmacokinetically enhanced N?-hydroxy-L-arginine (NOHA) derivatives and a method for producing the NOHA derivatives having enhanced physical-chemical and pharmacokinetic properties according to the invention.
    Type: Application
    Filed: January 4, 2010
    Publication date: May 17, 2012
    Applicant: Christian-Albrechts-Universitaet Zu Kiel
    Inventors: Bernd Clement, Dennis Schade, Jürke Kotthaus
  • Inhibitors of Dimethylarginine Dimethylaminohydrolase
    Publication number: 20110294878
    Abstract: The invention relates to an inhibitor of dimethylarginine dimethylaminohydrolase (DDAH) of general structural formula (I), wherein B is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromatic system having a ring size of 3 to 6; R1 is selected from the group of structures (i-vii), wherein R2, R3 and R4 are selected from the group consisting of hydrogen, an alkyl or aryl radical, R5 and R6 are selected from the group consisting of hydrogen, a hydrocarbon chain having a chain length of 1 to 8 and an aryl radical, R7, R8, R9 and R10 are selected from the group consisting of hydrogen, and alkyl or aryl radical; W is oxygen (O) or nitrogen (N); and X is a methylene group (CH2) or a secondary amino group (NH); Y is a branched or unbranched, substituted or non-substituted, saturated or unsaturated hydrocarbon chain having a chain length of 1 to 6 and/or a substituted or non-substituted aromat
    Type: Application
    Filed: December 8, 2009
    Publication date: December 1, 2011
    Applicant: CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
    Inventors: Bernd Clement, Jürke Kotthaus, Dennis Schade