Abstract: A surgical system and method for treatment of a bone defect are provided. The system includes a bone tamp that includes an outer shaft defining a first lumen and a second lumen. A first expandable body is coupled to the outer shaft. The first expandable body is in communication with the first lumen such that an inflation material may be moved through the first lumen and into the first expandable body. An inner shaft is movably positioned within the second lumen. The inner shaft defines a third lumen. A second expandable body is coupled to the inner shaft. The second expandable body is in communication with the third lumen such that an inflation material may be moved through the third lumen and into the second expandable body.

Abstract: A drug-eluting device comprising a drug-eluting matrix containing at least one elutable drug, a method of manufacturing a preformed drug-eluting device, and an implant kit comprising the same.

Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.

Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.

Abstract: A coated substrate comprises a substrate and a coating on at least one surface of the substrate. The coating comprises a prepolymer, polymer, or resin produced, for example, by the reaction of (i) an isocyanate (e.g., a polyisocyanate), (ii) an active hydrogen-terminated colorant, and optionally (iii) at least one reactant selected from the group consisting of chain extenders, polyols, internal surfactants, and combinations thereof. Polymer dispersions suitable for use in making such coated substrates comprise such a prepolymer, polymer, or resin.

Abstract: In one form, a method for stabilization of a facet joint of the spinal column includes forming a cavity between adjacent bones defining the facet joint and positioning an implant in the cavity between the adjacent bones. In one aspect of this form, the method also includes positioning a bone anchor across the facet joint and engaging the bone anchor with each of the adjacent bones to force the bones toward one another and clamp the implant therebetween. In a further aspect of this form, the implant is a cancellous bone dowel and becomes fractured into a plurality of fragments upon being clamped between the adjacent bones and/or otherwise interacting with the bone anchor. In another form, systems and devices for performing percutaneous facet joint stabilization and/or fusion are provided. However, different forms and applications are also envisioned.

Abstract: An apparatus for monitoring the characteristics of tissue adjacent a surgical site and communicating that information to a health care provider includes a retractor, a sensor, and a processing system. The sensor is disposed on the retractor and is configured to measure a parameter indicative of at least one characteristic of the tissue adjacent the first or the second blade. The processing system is in communication with the sensor and configured and arranged to receive information from the sensor indicative of the measured parameter. It includes a threshold stored therein indicative of excessive trauma to the tissue and it is configured in a manner such that it compares the received information to the stored threshold and communicates information to the health care provider regarding the comparison.

Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.

Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.

Abstract: In one form, a method for stabilization of a facet joint of the spinal column includes forming a cavity between adjacent bones defining the facet joint and positioning an implant in the cavity between the adjacent bones. In one aspect of this form, the method also includes positioning a bone anchor across the facet joint and engaging the bone anchor with each of the adjacent bones to force the bones toward one another and clamp the implant therebetween. In a further aspect of this form, the implant is a cancellous bone dowel and becomes fractured into a plurality of fragments upon being clamped between the adjacent bones and/or otherwise interacting with the bone anchor. In another form, systems and devices for performing percutaneous facet joint stabilization and/or fusion are provided. However, different forms and applications are also envisioned.

Abstract: An apparatus for monitoring the characteristics of tissue adjacent a surgical site and communicating that information to a health care provider includes a retractor, a sensor, and a processing system. The sensor is disposed on the retractor and is configured to measure a parameter indicative of at least one characteristic of the tissue adjacent the first or the second blade. The processing system is in communication with the sensor and configured and arranged to receive information from the sensor indicative of the measured parameter. It includes a threshold stored therein indicative of excessive trauma to the tissue and it is configured in a manner such that it compares the received information to the stored threshold and communicates information to the health care provider regarding the comparison.

Abstract: A coated substrate comprises a substrate and a coating on at least one surface of the substrate. The coating comprises a prepolymer, polymer, or resin produced, for example, by the reaction of (i) an isocyanate (e.g., a polyisocyanate), (ii) an active hydrogen-terminated colorant, and optionally (iii) at least one reactant selected from the group consisting of chain extenders, polyols, internal surfactants, and combinations thereof. Polymer dispersions suitable for use in making such coated substrates comprise such a prepolymer, polymer, or resin.

Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.

Abstract: A coated substrate comprises a substrate and a coating on at least one surface of the substrate. The coating comprises a prepolymer, polymer, or resin produced, for example, by the reaction of (i) an isocyanate (e.g., a polyisocyanate), (ii) an active hydrogen-terminated colorant, and optionally (iii) at least one reactant selected from the group consisting of chain extenders, polyols, internal surfactants, and combinations thereof. Polymer dispersions suitable for use in making such coated substrates comprise such a prepolymer, polymer, or resin.

Abstract: Novel synthetic leather articles comprise a substrate and a coating applied to a surface of the substrate. The coating comprises a resin and a polymeric colorant. The polymeric colorant comprises a chromophore and an oligomeric constituent bound to the chromophore. Novel methods for producing synthetic leather articles using polymeric colorants are also provided.

Abstract: A drug-eluting device comprising a drug-eluting matrix containing at least one elutable drug, a method of manufacturing a preformed drug-eluting device, and an implant kit comprising the same.

Abstract: The present invention is directed to compounds of the formula (I) and (II) or salts thereof or N-oxides and their use in peptide synthesis.

Abstract: A drug-eluting implant cover fabricated from a drug-eluting biocompatible matrix containing at least one elutable drug, a drug-eluting implant cover kit containing at least one drug-eluting implant cover, and a method of manufacturing the same.

Abstract: Novel synthetic leather articles comprise a substrate and a coating applied to a surface of the substrate. The coating comprises a resin and a polymeric colorant. The polymeric colorant comprises a chromophore and an oligomeric constituent bound to the chromophore. Novel methods for producing synthetic leather articles using polymeric colorants are also provided.

Abstract: This invention provides a novel class of compounds and compositions and synthetic methods related to lactone antioxidant 3-arylbenzofuranones. The compounds may be useful to prevent yellowing and deterioration of organic materials preferably polymers, such as polyurethane foams as one example. The lactone antioxidants may be polymeric, and may also be liquid or paste in physical form at room temperature. Although it is not necessary for its stabilizing properties, the compositions may, in some species, bear one or more reactive primary OH groups on the polymer chains. The chains may also contain oligomeric oxyalkylene ether and aliphatic ester functional groups, in one embodiment of the invention.