Patents by Inventor Justin A. MODICA

Justin A. MODICA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11530404
    Abstract: Enzyme-immobilizing MOFs and methods for their use in enzymatically catalyzed reactions are provided. The MOFs are channel-type MOFs that present a hierarchical pore structure comprising a first set of large channels sized for enzyme immobilization and a second set of smaller channels running alongside of the large channels that remain enzyme-free and allow for reactant delivery to the enzymes and product expulsion from the larger channels.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: December 20, 2022
    Assignee: Northwestern University
    Inventors: Omar K. Farha, Peng Li, Justin A. Modica, Milan Mrksich, Joseph T. Hupp
  • Publication number: 20190161556
    Abstract: The disclosure provides constructs comprising a first fusion protein, a second fusion protein, and a linker, wherein the first fusion protein and the second fusion protein each include an affinity reagent and a reactive enzyme, and the linker includes a first and second functional groups specific for irreversibly inhibiting the first and second fusion protein reactive enzymes. The disclosure further provides a method including (a) contacting a first fusion protein including an affinity reagent and a reactive enzyme with a linker including a functional group specific for irreversibly inhibiting the first fusion protein reactive enzyme thereby coupling the first fusion protein and the linker, and (b) contacting a second fusion protein including an affinity reagent and a reactive enzyme with the linker, the linker including a functional group specific for irreversibly inhibiting the second fusion protein reactive enzyme thereby coupling the second fusion protein and the linker.
    Type: Application
    Filed: June 6, 2017
    Publication date: May 30, 2019
    Inventors: Milan Mrksich, Justin A. Modica
  • Publication number: 20190112591
    Abstract: Enzyme-immobilizing MOFs and methods for their use in enzymatically catalyzed reactions are provided. The MOFs are channel-type MOFs that present a hierarchical pore structure comprising a first set of large channels sized for enzyme immobilization and a second set of smaller channels running alongside of the large channels that remain enzyme-free and allow for reactant delivery to the enzymes and product expulsion from the larger channels.
    Type: Application
    Filed: May 25, 2017
    Publication date: April 18, 2019
    Inventors: Omar F. FARHA, Peng LI, Justin A. MODICA, Milan MRKSICH, Joseph T. HUPP