Abstract: The invention relates to a process for producing an aqueous polymer dispersion by means of radically initiated aqueous emulsion polymerisation by polymerising, in an aqueous medium, in accordance with a monomer feed process: (a) 40 to 75 parts by weight styrene; (b) 24.9 to 59.9 parts by weight butadiene; (c) 0.1 to 10 parts by weight of at least one ethylenically unsaturated carboxylic acid; and (d) 0 to 15 parts by weight other monomers, wherein the parts by weight of monomers (a) to (d) add up to 100 parts by weight, which process comprises the following steps: a) creating a template of a seed latex and 1 to 10 parts by weight monomers, based on the total monomer amount; b) starting the polymerisation at a temperature ?80° C.

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: System and method of managing one or more surgical articles, wherein the surgical article can include a surgical sponge comprising an identification element, and wherein managing can include counting, locating, or both. The identification element can be a RFID tag. The RFID tag stores unique identification information relative to the surgical sponge. The system and method for detecting RFID tags may include varying the power level of the RFID interrogator to improve the accuracy of scanning the RFID tag or tags. A plurality of the RFID-tagged surgical articles (i.e., surgical sponges) may be packaged or bundled via a strap or within a container.

Abstract: An aspect of the invention relates to a moving image distribution system. The moving image distribution system may include one or more processors. The one or more processors may execute a computer-readable command to register a distribution user that has made a registration request among a plurality of distribution users that distribute moving images including character objects generated based on their own movements, as a first co-starrable user, to select a first co-starring user from among a plurality of first co-starrable users in response to reception of a first co-starring application for co-starring with any of the plurality of first co-starrable users from a co-starring application user, and to distribute a co-starring moving image in which the co-starring application user and the first co-starring user co-star.

Abstract: A method of accessing media includes establishing a first network connection between a service provider device and a media device, wherein establishing the first network connection includes exchanging a set of network access parameters; establishing a second network connection between a user device and the service provider device; providing to a user device the set of network access parameters of the first network connection using the service provider device; and using the user device to control the media device, the user device using the set of network access parameters to mimic the first network connection with the media device.

Abstract: A system and method for refrigerated packaging and temperature modulation is disclosed. A unique hydrogel formulation comprising a superabsorbent polymer functioning through osmosis, water-soluble binding agent, wicking agent, and an osmosis interfering agent allows a package to be cooled by regular ice without the product or container becoming wet as the ice melts. Hydrogels may be shaped into a container with ice and products placed inside of it. Several additives may be added to the hydrogel formulation to give, remove, or enhance certain properties. A number of additional applications of the inventions are disclosed including agricultural, structural cooling, home and beauty, athletic, medical, work, and other applications.

Abstract: A system may include an exercise device and an external device. The exercise device may include a rigid rod, a plurality of light sources, at least one load sensor for detecting an applied longitudinal force, and a first processor coupled to the at least one load sensor and to the plurality of light sources and configured to obtain a signal indicating a magnitude of the applied longitudinal force, and cause a subset of the plurality of light sources to emit light. The external device may comprise a communication interface, a display, and a second processor coupled to the communication interface and to the display and configured to establish a communication link with the exercise device using the communication interface, obtain data over the communication link, and cause the display to present information associated with the exercise device.

Abstract: Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

Abstract: Systems and methods related to generating machine code using a coroutine suspension mechanism are disclosed below. An asynchronous programming model utilizing coroutines may be implemented in a compiler for a high-level programming language. The compiler is configured to include functionality related to an intrinsic function for a suspend operation of a coroutine. In accordance with an aspect of the disclosure, a method is disclosed for generating machine code that includes the coroutine mechanism. The method includes: receiving source code for a program in a high-level programming language, and compiling the source code with a compiler to generate machine code for a target processor. The source code includes a caller and a coroutine called by the caller. The compiler is configured to detect an intrinsic function for a suspend operation in the source code for the coroutine. The compiler inserts low-level code in the machine code in accordance with an ABI.

Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3?, R4, R5, X1, X2, X3, X4, and n are described herein.

Abstract: The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5? and R6 are described herein.

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: Payload containers containing temperature modulators and coolant containers containing coolant movably coupled inside of an outer container. Temperature modulators contain one or more solutions that directionally freeze when the product container is in contact with the coolant container, exerting force to push thermal conductors apart. When thermal conductors are apart, air flow and thermal conduction from the coolant container to the payload container is reduced, thereby stopping the cooling of the payload container. When the one or more solutions melt, the thermal conductors reconnect, reestablishing the cooling of the payload container. The modulation allows the payload to stay within safe temperature ranges.

Abstract: A method of accessing media includes establishing a first network connection between a service provider device and a media device, wherein establishing the first network connection includes exchanging a set of network access parameters; establishing a second network connection between a user device and the service provider device; providing to a user device the set of network access parameters of the first network connection using the service provider device; and using the user device to control the media device, the user device using the set of network access parameters to mimic the first network connection with the media device.

Abstract: Provided herein are fusion protein constructs that can bind a complement-associated antigen, comprising a targeting moiety and a complement modulator protein, or a fragment thereof or a variant thereof. The targeting moiety is an antibody or an antigen binding fragment thereof, in some examples. Further provided are methods of using the fusion protein constructs, for example, in treating complement mediation conditions.

Abstract: Systems and methods related to generating machine code using a coroutine suspension mechanism are disclosed below. An asynchronous programming model utilizing coroutines may be implemented in a compiler for a high-level programming language. The compiler is configured to include functionality related to an intrinsic function for a suspend operation of a coroutine. In accordance with an aspect of the disclosure, a method is disclosed for generating machine code that includes the coroutine mechanism. The method includes: receiving source code for a program in a high-level programming language, and compiling the source code with a compiler to generate machine code for a target processor. The source code includes a caller and a coroutine called by the caller. The compiler is configured to detect an intrinsic function for a suspend operation in the source code for the coroutine. The compiler inserts low-level code in the machine code in accordance with an ABI.

Abstract: The disclosure relates to USP30 Inhibitor Compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same.

Abstract: A system may include an exercise device and an external device. The exercise device may include a rigid rod, a plurality of light sources, at least one load sensor for detecting an applied longitudinal force, and a first processor coupled to the at least one load sensor and to the plurality of light sources and configured to obtain a signal indicating a magnitude of the applied longitudinal force, and cause a subset of the plurality of light sources to emit light. The external device may comprise a communication interface, a display, and a second processor coupled to the communication interface and to the display and configured to establish a communication link with the exercise device using the communication interface, obtain data over the communication link, and cause the display to present information associated with the exercise device.

Abstract: A molding system and a method for forming a sole structure are provided. The method includes flowing a molten polymeric material into a mold from an upstream device, receiving the molten polymeric material in a cavity of the mold, and maintaining a repeatable, uniform pressure profile as the molten polymeric material is delivered into the mold.