Abstract: The present invention relates to a gene editing system for editing the arylsulfatase A (ARSA) gene, polynucleotides, sgRNA molecules and repair templates which may form parts of the gene editing system, vectors and host cells incorporating said nucleic acid molecules, a pharmaceutical composition, and kits. It also relates to a method of gene editing the arylsulfatase A (ARSA) gene in a cell or a subject, and to a method of treating a disease or disorder associated with functional deficiency of the ARSA enzyme in a subject.

Abstract: Disclosed is a method for defining a structure of an annular light guide device, for a fundus camera. An initial cross section of a wall of a light guide device is created in predefined way. A hollow cavity for a light source is defined within this cross section. The surface of the hollow cavity is an ellipsoid. Using a ray tracing software tool, the initial cross section is refined to maximise total internal reflection of the light from the source within the cross section to achieve most efficient light guide device. Once the final cross section is created, it is rotated by 360 degrees on a predefined axis to obtain final structure of the light guide device. The method is developed for creating very small light guide as required in a fundus camera especially for neonatal applications.

Abstract: The present invention relates to compositions of recombinant polynucleic acid or RNA constructs comprising a first RNA sequence, a second RNA sequence, and a linker RNA sequence, wherein the linker RNA links the first RNA sequence and the second RNA sequence. In addition, linkers that enhance the cleavage of recombinant RNA constructs are described. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to compositions and methods for modulating expression of genes, comprising recombinant polynucleic acid or RNA constructs comprising a first RNA sequence encoding a gene of interest, and a second RNA sequence comprising at least two genetic elements that modulate expression of one or more target RNAs. The recombinant RNA constructs described herein induce an immune response in a human cell that is lower than the immune response induced by a corresponding recombinant RNA construct comprising the first RNA sequence encoding a gene of interest and a corresponding second RNA sequence comprising at most one of the at least two genetic elements. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to a mRNA and a therapeutic composition thereof for use in a method of treating lower urinary tract symptoms.

Abstract: Disclosed is a device for generating a toroidal source of illumination is disclosed. The device comprises a translucent disc with a concentric hole. A planar coil of side emitting optic fiber is disposed on one surface of the disc. The coil is energized with an LED at one end of the coil. The light emitted by the side of the coil is randomly scattered by the disc producing a toroidal source of light at the other surface of the disc. This source is used with instruments for assessing the dryness of the human eye. Further embodiments describe adaptations for measuring tear breakup time and the height of the tear meniscus in the human eye.

Abstract: The present invention relates to compositions of recombinant polynucleic acid constructs comprising at least one nucleic acid sequence encoding an siRNA capable of binding to a target mRNA and at least one nucleic acid sequence encoding a gene of interest. Also disclosed herein is use of the compositions in treating cancers and in simultaneously modulating expression of two or more genes.

Abstract: In some aspects, a display device may receive a distance measurement from a sensor. The distance measurement may be indicative of a dimension of the rollable display panel of the display device. The display device may configure, based on the distance measurement, an output setting for displayed content of the rollable display panel according to the dimension. Numerous other aspects are described.

Abstract: The present invention relates to compositions of recombinant polynucleic acid constructs comprising at least one nucleic acid sequence encoding an siRNA capable of binding to a target mRNA and at least one nucleic acid sequence encoding a gene of interest. Also disclosed herein is use of the compositions in treating a disease or a condition and in simultaneously modulating expression of two or more genes.

Abstract: In some aspects, a display device may receive a distance measurement from a sensor. The distance measurement may be indicative of a dimension of the rollable display panel of the display device. The display device may configure, based on the distance measurement, an output setting for displayed content of the rollable display panel according to the dimension. Numerous other aspects are described.

Abstract: Various embodiments include methods, components and wireless devices configured to manage a presentation of the notification of an incoming communication on a wireless device. In some embodiments, a sender wireless device may send to a receiver wireless device a communication and a notification suggestion code including one or more notification suggestions that the receiver wireless device may determine to use for modifying a notification on the receiver wireless device.

Abstract: The present invention relates to a mRNA comprising a nucleic acid sequence encoding a protein and a signal peptide and a transcription unit, an expression vector or a gene therapy vector comprising a nucleic acid encoding a protein and a signal peptide. Also disclosed herein is a therapeutic composition comprising said mRNA, transcription unit, expression vector or gene therapy vector and use of the therapeutic composition in treating a disease or a condition.

Abstract: Various embodiments include methods, components and wireless devices configured to manage a presentation of the notification of an incoming communication on a wireless device. In some embodiments, a sender wireless device may send to a receiver wireless device a communication and a notification suggestion code including one or more notification suggestions that the receiver wireless device may determine to use for modifying a notification on the receiver wireless device.