Abstract: Among other things, the present disclosure provides oligonucleotides targeting SARM1 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.

Abstract: Among other things, the present disclosure provides oligonucleotides targeting calpain-2 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.

Abstract: An osteotomy procedure may be performed to correct a misalignment of a bone, such as a bunion deformity. In some examples, the osteotomy procedure involves making a spherical-shaped cut transecting a first metatarsal, thereby forming a first metatarsal portion having a spherical-shaped projection and a second metatarsal portion having a spherical-shaped recess. The method further involves moving the second metatarsal portion in at least two planes relative to the first metatarsal portion, thereby adjusting an anatomical alignment of the second metatarsal portion.

Abstract: Yarns incorporating filaments of shape memory materials are described herein that enable the creation of fabrics, garments, and other materials with tunable force absorption or exertion capabilities, as well as creating complex shapes and structures upon actuation. Systems and methods described herein enable selective buckling, recruitment, compression, and other desirable phenomena by actuating fibers in knitted patterns, whether used as isolated filaments or in twisted yarns.

Abstract: A method for providing real estate data on an interactive map which provides an interactive map display over which various real estate data layers may be overlaid to provide information regarding displayed property parcels. The present invention generally includes a central communication unit and a user device communicatively interconnected with the central communication unit via a communications network. The central communication unit is adapted to periodically access real estate data from one or more data providers to maintain a data repository containing real estate data regarding a plurality of properties. The user device utilizes a software application to retrieve such real estate data from the central communication unit and display a user interface having a map showing a plurality of map tiles. A data layer may be overlaid over the map to provide the real estate data in an easy-to-read manner while exploring a geographic area on the map.

Abstract: An holistic exercise method for enhancing urine retention in a person having reduced urine retention and exercise belt therefore. The method includes: a) providing an elastic resistance exercise belt of a size sufficient to encircle a users abdominopelvic region; b) removably mounting the belt around the abdominopelvic region of the user; c) expanding the abdominopelvic region outward as far as possible by the user against the resistive force of the belt; and then d) pulling the abdominopelvic region back into the body as far as possible with the resistance belt elastically retained in a snug position against the exterior of the abdominopelvic region; e) repeating a cycle comprising the expanding step c) and the pulling step d) for a sufficient number of cycles per day for a sufficient number of days to enhance the urine retention of the person.

Abstract: An holistic exercise method for enhancing urine retention in a person having reduced urine retention and exercise belt therefore. The method includes: a) providing an elastic resistance exercise belt of a size sufficient to encircle a users abdominopelvic region; b) removably mounting the belt around the abdominopelvic region of the user; c) expanding the abdominopelvic region outward as far as possible by the user against the resistive force of the belt; and then d) pulling the abdominopelvic region back into the body as far as possible with the resistance belt elastically retained in a snug position against the exterior of the abdominopelvic region; e) repeating a cycle comprising the expanding step c) and the pulling step d) for a sufficient number of cycles per day for a sufficient number of days to enhance the urine retention of the person.

Abstract: An holistic exercise method for enhancing urine retention in a person having reduced urine retention and exercise belt therefore. The method includes: a) providing an elastic resistance exercise belt of a size sufficient to encircle a users abdominopelvic region; b) removably mounting the belt around the abdominopelvic region of the user; c) expanding the abdominopelvic region outward as far as possible by the user against the resistive force of the belt; and then d) pulling the abdominopelvic region back into the body as far as possible with the resistance belt elastically retained in a snug position against the exterior of the abdominopelvic region; e) repeating a cycle comprising the expanding step c) and the pulling step d) for a sufficient number of cycles per day for a sufficient number of days to enhance the urine retention of the person.