Patents by Inventor Justin Blau

Justin Blau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of reducing neuronal electrical activity with a potassium channel subunit
    Patent number: 7192773
    Abstract: Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K+ channel (dORK) (SEQ ID NO:2) or a modified open rectifier K+ channel (dORK?) (SEQ ID NO:4), and expressing the open rectifier K+ channel in the excitable cell, wherein the excitability of the transformed cell is reduced. Also featured are transgenic animals expressing dORK or dORK?.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: March 20, 2007
    Assignee: New York University
    Inventors: Michael N. Nitabach, Justin Blau, Todd C. Holmes, Steven A. N. Goldstein
  • Method of reducing neuronal electrical activity with a potassium channel subunit
    Publication number: 20030237102
    Abstract: Methods of reducing the excitability of an excitable cell by transforming an excitable cell with a nucleic acid construct encoding an open rectifier K+ channel (dORK) (SEQ ID NO:2) or a modified open rectifier K+ channel (dORK&Dgr;) (SEQ ID NO:4), and expressing the open rectifier K+ channel in the excitable cell, wherein the excitability of the transformed cell is reduced. Also featured are transgenic animals expressing dORK or dORK&Dgr;.
    Type: Application
    Filed: May 15, 2003
    Publication date: December 25, 2003
    Inventors: Michael N. Nitabach, Justin Blau, Todd C. Holmes, Steven A. N. Goldstein
  • Clock gene and methods of use thereof
    Patent number: 6476188
    Abstract: The present invention discloses the identity of the first enzyme that has been demonstrated to be involved in maintaining circadian rhythms. This enzyme, the Drosophila DOUBLETIME protein is also shown to be an ortholog of human casein kinase-1&egr;. In addition, a variant of this enzyme is shown to be cause of the hamster tau mutant phenotype. Thus the present invention also relates to variants of DOUBLETIME, and their nucleic acid and amino acid sequences. The present invention further provides methods of using these variants in drug assays and diagnostics.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: November 5, 2002
    Assignees: The Rockefeller University, Northwestern University
    Inventors: Michael W. Young, Brian Kloss, Justin Blau, Jeffrey Price, Joseph S. Takahashi, Phillip L. Lowrey
  • Methods of identifying an agent which modulates period and doubletime protein interaction
    Patent number: 6436628
    Abstract: The present invention provides isolated nucleic acids and/or recombinant DNA molecules that encode the clock protein DOUBLETIME. The present invention further provides both isolated and/or recombinant DOUBLETIME. In addition, the present invention provides antibodies to DOUBLETIME. Methods of using the nucleic acids, proteins and antibodies of the present invention, including as therapeutics are also provided.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: August 20, 2002
    Assignee: The Rockefeller University
    Inventors: Michael W. Young, Brian Kloss, Justin Blau, Jeffrey Price
  • Clock gene and methods of use thereof
    Patent number: 6057129
    Abstract: The present invention provides isolated nucleic acids and/or recombinant DNA molecules that encode the clock protein DOUBLETIME. The present invention further provides both isolated and/or recombinant DOUBLETIME. In addition, the present invention provides antibodies to DOUBLETIME. Methods of using the nucleic acids, proteins and antibodies of the present invention, including as therapeutics are also provided.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: May 2, 2000
    Assignee: The Rockfeller University
    Inventors: Michael W. Young, Brian Kloss, Justin Blau, Jeffrey Price