Patents by Inventor Justin Bloomfield SIEGEL

Justin Bloomfield SIEGEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE
    Publication number: 20230130764
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Application
    Filed: September 13, 2022
    Publication date: April 27, 2023
    Inventors: Ingrid Swanson PULTZ, Clancey WOLF, Justin Bloomfield SIEGEL, Christine Elaine TINBERG, Lance STEWART, David BAKER
  • Compositions and methods for treating celiac sprue disease
    Patent number: 11485961
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQFQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Grant
    Filed: September 14, 2020
    Date of Patent: November 1, 2022
    Assignees: University of Washington, The Regents of the University of California
    Inventors: Ingrid Swanson Pultz, Clancey Wolf, Justin Bloomfield Siegel, Christine Elaine Tinberg, Lance Stewart, David Baker
  • Compositions and Methods for Treating Celiac Sprue Disease
    Publication number: 20210246437
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Application
    Filed: April 14, 2021
    Publication date: August 12, 2021
    Inventors: Justin Bloomfield SIEGEL, David BAKER, Ingrid Swanson PULTZ
  • COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE
    Publication number: 20210171928
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQFQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Application
    Filed: September 14, 2020
    Publication date: June 10, 2021
    Inventors: Ingrid Swanson PULTZ, Clancey WOLF, Justin Bloomfield SIEGEL, Christine Elaine TINBERG, Lance STEWART, David BAKER
  • Compositions and methods for treating celiac sprue disease
    Patent number: 11008558
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: May 18, 2021
    Assignee: University of Washington
    Inventors: Justin Bloomfield Siegel, David Baker, Ingrid Swanson Pultz
  • Compositions and methods for treating celiac sprue disease
    Patent number: 10988748
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: April 27, 2021
    Assignees: University of Washington, The Regents of the University of California
    Inventors: Ingrid Swanson Pultz, Clancey Wolf, Justin Bloomfield Siegel, Christine Elaine Tinberg, Lance Stewart, David Baker
  • Compositions and methods for treating celiac sprue disease
    Patent number: 10793846
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO: 1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: October 6, 2020
    Assignees: University of Washington, The Regents of the University of California
    Inventors: Ingrid Swanson Pultz, Clancey Wolf, Justin Bloomfield Siegel, Christine Elaine Tinberg, Lance Stewart, David Baker
  • Compositions and Methods for Treating Celiac Sprue Disease
    Publication number: 20200123521
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Application
    Filed: November 22, 2019
    Publication date: April 23, 2020
    Inventors: Justin Bloomfield SIEGEL, David BAKER, Ingrid Swanson PULTZ
  • COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE
    Publication number: 20200109387
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO:1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Application
    Filed: December 18, 2019
    Publication date: April 9, 2020
    Inventors: Ingrid Swanson PULTZ, Clancey WOLF, Justin Bloomfield SIEGEL, Christine Elaine TINBERG, Lance STEWART, David BAKER
  • Compositions and methods for treating celiac sprue disease
    Patent number: 10487318
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: November 26, 2019
    Assignee: University of Washington Through its Center for Commercialization
    Inventors: Justin Bloomfield Siegel, David Baker, Ingrid Swanson Pultz
  • Compositions and methods for treating celiac sprue disease
    Patent number: 10266815
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: April 23, 2019
    Assignee: University of Washington Through Its Center for Commercialization
    Inventors: Justin Bloomfield Siegel, David Baker, Ingrid Swanson Pultz
  • COMPOSITIONS AND METHODS FOR TREATING CELIAC SPRUE DISEASE
    Publication number: 20180142226
    Abstract: Polypeptides, and methods for their use, are disclosed that have an amino acid sequence at least 75% identical to the amino acid sequence of SEQ ID NO: 1, are provided, wherein (a) the polypeptide degrades a PFQPQLPY (SEQ ID NO: 140) peptide and/or a PFPQPQQPF (SEQ ID NO: 68) at pH 4; (b) residue 467 is Ser, residue 267 is Glu, and residue 271 is Asp; and (c) the polypeptide comprises an amino acid change from SEQ ID NO: 1 at one or more residues selected from the group consisting of 221, 262E, 268, 269, 270, 319A, 320, 354E/Q/R/Y, 358S/Q/T, 368F/Q, 399, 402, 406, 424, 449, 461, 463, 105, 171, 172, 173, 174, and 456.
    Type: Application
    Filed: June 8, 2016
    Publication date: May 24, 2018
    Inventors: Ingrid Swanson PULTZ, Clancey WOLF, Justin Bloomfield SIEGEL, Christine Elaine TINBERG, Lance STEWART, David BAKER
  • Compositions and Methods for Treating Celiac Sprue Disease
    Publication number: 20160194621
    Abstract: The invention provides compositions and methods for treating celiac sprue.
    Type: Application
    Filed: August 13, 2014
    Publication date: July 7, 2016
    Inventors: Justin Bloomfield SIEGEL, David BAKER, Ingrid Swanson PULTZ