Abstract: The present disclosure relates to development and performance of screening methods capable of efficiently identifying candidate lead compounds that bind regulatory RNA oligonucleotides in a sequence-specific manner and exert a biological effect upon such regulatory molecules. Candidate lead compounds possessing RNA binding sequence specificity and targeted biological activity are described, as are approaches for merging structural, NMR-derived data with biological reporter assay results. Compound validation approaches capable of identifying the site(s) of action of such compounds within targeted RNA oligonucleotides are also provided.

Abstract: The present disclosure describes a method to determine whether a physical identification document is authentic. An authentication manager receives an image of a physical identification document to be authenticated. The authentication manager extracts a set of characteristics of the document from the image. The authentication manager determines a class of the document based on the set of characteristics. The authentication manager applies a convolution kernel, convolving the image with the kernel to generate a feature map. The authentication manager determines a score based on the feature map, where the score identifies the likelihood that the document is valid. The authentication manager then provides an indication that the physical document is authentic based on the score.

Abstract: The present disclosure describes a method to determine whether a physical identification document is authentic. An authentication manager receives an image of a physical identification document to be authenticated. The authentication manager extracts a set of characteristics of the document from the image. The authentication manager determines a class of the document based on the set of characteristics. The authentication manager applies a convolution kernel, convolving the image with the kernel to generate a feature map. The authentication manager determines a score based on the feature map, where the score identifies the likelihood that the document is valid. The authentication manager then provides an indication that the physical document is authentic based on the score.

Abstract: The present disclosure describes systems and methods to classify and authenticate ID documents based on the information contained on the face of the ID document. This present system can automatically classify, authenticate, and extracting data from documents using artificial intelligence (AI) based machine learning for image recognition. In some implementations, the machine learning techniques include a convolutional neural network. The system can also determine the authenticity of other documents, such as currency, stamps, and invoices.

Abstract: An attraction for an adventure park or for entertainment including: a first course; a second course; participants make progress along either of the first and second courses; and participants progressing along the first course can engage in a shooting based activity with participants progressing along the second course.

Abstract: The present disclosure describes systems and methods to classify and authenticate ID documents based on the information contained on the face of the ID document. This present system can automatically classify, authenticate, and extracting data from documents using artificial intelligence (AI) based machine learning for image recognition. In some implementations, the machine learning techniques include a convolutional neural network. The system can also determine the authenticity of other documents, such as currency, stamps, and invoices.

Abstract: Herein, compounds and compositions for use in treating diseases relating to inclusion formation and stress granules are described. Methods for screening for modulation of TDP-43 aggregation are also described.

Abstract: Herein, methods of modulating inclusion formation and stress granules in cells are described. The methods comprise contacting a cell with an inclusion inhibitor. Methods for screening for modulators of TDP-43 aggregation are also described.

Abstract: A method of displaying and merchandising a product that that provides customer interaction and product synchronization is disclosed. The method provides a product display that may include an upright display member having an illuminating member and lighting niches through which dynamic light shows may be projected. A product may be positioned in a lighting niche. A product experience shelf may also be coupled to the upright display member. The product experience shelf may include translucent recesses for holding and illuminating products and or samples of products. The product experience shelf may also incorporate an illuminated ring or border lining the outer edge of each recess for additional lighting effects. The method also provides an interactive customer interface that allows customers to adjust a control module which coordinates synchronized dynamic light shows throughout the display. The customer interface may also be illuminated and positioned on the product experience shelf.

Abstract: An illuminating product display providing customer interaction and product synchronization is disclosed. The product display may include an upright display member having an illuminating member and lighting niches through which dynamic light shows may be projected. A product may be positioned in a lighting niche. A product experience shelf may also be coupled to the upright display member. The product experience shelf may include translucent recesses for holding and illuminating demonstration products. The product experience shelf may also incorporate an illuminated ring or border lining the outer edge of each recess for additional lighting effects. An interactive customer interface may allow customers to adjust a control module which coordinates synchronized dynamic light shows throughout the display. The customer interface may also be illuminated and positioned on the product experience shelf. Furthermore, the dynamic light shows may be synchronized with the lighting products.

Abstract: An illuminating product display providing customer interaction and product synchronization is disclosed. The product display may include an upright display member having an illuminating member and lighting niches through which dynamic light shows may be projected. A product may be positioned in a lighting niche. A product experience shelf may also be coupled to the upright display member. The product experience shelf may include translucent recesses for holding and illuminating demonstration products. The product experience shelf may also incorporate an illuminated ring or border lining the outer edge of each recess for additional lighting effects. An interactive customer interface may allow customers to adjust a control module which coordinates synchronized dynamic light shows throughout the display. The customer interface may also be illuminated and positioned on the product experience shelf. Furthermore, the dynamic light shows may be synchronized with the lighting products.

Abstract: A method of displaying and merchandising a product that that provides customer interaction and product synchronization is disclosed. The method provides a product display that may include an upright display member having an illuminating member and lighting niches through which dynamic light shows may be projected. A product may be positioned in a lighting niche. A product experience shelf may also be coupled to the upright display member. The product experience shelf may include translucent recesses for holding and illuminating products and or samples of products. The product experience shelf may also incorporate an illuminated ring or border lining the outer edge of each recess for additional lighting effects. The method also provides an interactive customer interface that allows customers to adjust a control module which coordinates synchronized dynamic light shows throughout the display. The customer interface may also be illuminated and positioned on the product experience shelf.

Abstract: A mode converter for converting an optical signal from a first propagation mode (e.g., LP01) to a second propagation mode (e.g., LP02). The mode converter includes a first waveguide supporting a first mode of propagation. The mode converter also includes a second waveguide supporting a second mode of propagation. The first and second waveguides each having a group index characteristic, wherein the first group index characteristic is matched with the second group index characteristic such that electromagnetic energy propagating through the first waveguide at the first mode couples to the second waveguide at the second mode.

Abstract: A mode converter for converting an optical signal from a first propagation mode (e.g., LP01) to a second propagation mode (e.g., LP02). The mode converter includes a first waveguide supporting a first mode of propagation. The mode converter also includes a second waveguide supporting a second mode of propagation. The first and second waveguides each having a group index characteristic, wherein the first group index characteristic is matched with the second group index characteristic such that electromagnetic energy propagating through the first waveguide at the first mode couples to the second waveguide at the second mode.

Abstract: In accordance with the invention, a multiwavelength light source comprises a length of optical waveguide amplifier, a multiwavelength reflector for reflecting a plurality of different spectrally separated wavelengths optically coupled to one side of the amplifier and a low reflection output coupled to the other side. A broadband source is provided for passing broadband light to the multiwavelength reflector. In the preferred embodiment, the reflector is a plurality of reflective Bragg gratings, the waveguide amplifier is a length of rare-earth doped fiber (e.g. EDF) and the broadband source is the amplifier pumped to generate ASE. In operation, broadband light is transmitted to the gratings. Light of wavelength channels corresponding to the reflection wavelengths of the gratings is reflected back through the amplifier for further amplification before it arrives at the output.

Abstract: This invention is predicated on applicants' discovery that one can design long-period gratings having a center wavelength versus A characteristic which changes polarity of slope near a wavelength of interest. Such a grating can be chirped to exhibit a wider bandwidth than chirped conventional gratings, e.g. 100 nm as compared to 20 nm. The new wide bandwidth gratings are highly useful in optical communications systems for dispersion compensation and for compensation of spectrally dependent optical amplifiers.

Abstract: In accordance with the invention, an optical switch employs a long-period grating for switching light between alternative optical paths. In essence, the device comprises a variable intensity light source, a length of optical waveguide dimensioned for co-propagating light in two distinguishable modes, and a long-period grating in the waveguide for coupling between the two modes. The waveguide is nonlinear so that the effective refractive index is a function of intensity. As a consequence the coupling produced by the grating is a function of intensity. Thus different levels of light intensity can switch between the separate modes. Advantageously a mode separator is provided for directing light in the two modes onto respectively different optical output paths. A variety of two-mode switches and optical limiters are described, as well as an optical system using the switch.

Abstract: The present invention provides an optical signal shaping device, such as a long period grating, for use with an optical fiber having a core of a first prescribed refractive index n.sub.1 and a cladding of a second prescribed refractive index n.sub.2 and configured to transmit an optical signal therethrough. The optical signal shaping device comprises a long period grating of predetermined length formed within the optical fiber. The long period grating has a nonuniform refractive index profile extending over at least a portion of the predetermined length and is configured to alter the optical signal to produce an asymmetrical optical signal.

Abstract: The present applicants have discovered that one can fabricate a long-period grating wherein the grating peak wavelength .lambda..sub.p will be shifted in different directions when the grating is subject to temperature and tensile strain, respectively. Accordingly, a long-period grating can be designed and packaged such that a temperature-induced shift in .lambda..sub.p is compensated by a corresponding strain-induced shift arising from a single packaging material. Thus, by proper design of the grating and choice of the packaging material expansion coefficient, a temperature stable grating having temperature sensitivity of less than 4 nm per 100.degree. C. can comprise a grating fiber encased in or attached to a package comprising a single material such as glass, polymer or metal. Such designs permit the use of long-period grating devices without temperature control.

Abstract: Applicants have determined that the temperature sensitivity of long-period grating devices is due to differential variation with temperature of the refractive indices of the core and cladding. They have further determined that the cladding profile and fiber composition can be redesigned to substantially reduce this differential variation, thereby reducing the temperature sensitivity of long-period gratings of less than 4 nm per 100.degree. C. and preferably less than 2 nm per 100.degree. C. This design permits the use of long-period grating devices without temperature control or compensation.