Abstract: A package arrangement is provided. The package arrangement includes a package including a compartment defined by a wall. The wall includes a flexible portion. The compartment stores a beneficial agent. The compartment at least partially collapses in response to applied pressure. The compartment is hermetically sealed in a storage configuration. The package includes a rigid insert including a conduit in fluid communication with the compartment. The rigid insert is positioned inside the compartment and includes an insert coupling portion. The package arrangement further includes a rigid frame containing part of the compartment within the rigid frame. The rigid frame includes a frame coupling portion. The insert coupling portion exerts pressure on the frame coupling portion through the flexible portion to restrict motion of the rigid insert relative to the rigid frame. The flexible portion hermetically seals a proximal portion of the conduit in the storage configuration.