Patents by Inventor Justin Cotney

Justin Cotney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating disorders of genomic imprinting
    Patent number: 12018255
    Abstract: Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein to the ZNF274 binding site is reduced relative to a control. The ZNF274 binding site comprises a polynucleotide having at least 90% sequence identify to SEQ ID NO: 1 or SEQ ID NO: 42. Further provided are DNA targeting systems that bind to a ZNF274 binding site or to a gene encoding a ZNF274 protein.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: June 25, 2024
    Assignee: University of Connecticut
    Inventors: Stormy Chamberlain, Justin Cotney, Maéva Langouët, Marc Lalande
  • Neuronal enhancers
    Patent number: 11364309
    Abstract: A delivery vehicle which comprises a nucleic acid construct, wherein the nucleic acid construct comprises (i) an enhancer which specifically drives gene expression in cells of the entorhinal cortex (ii) a promoter; and (iii) a therapeutic gene, wherein said enhancer, promoter and therapeutic gene are operatively linked, said enhancer and therapeutic gene are heterologous, and said delivery vehicle is suitable for delivery of the nucleic acid construct to the brain of a mammal.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: June 21, 2022
    Assignees: NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY (NTNU), UNIVERSITY OF CONNECTICUT
    Inventors: Justin Cotney, Clifford Kentros, Stefan Blankvoort, Rajeevkumar Raveendran Nair
  • COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF GENOMIC IMPRINTING
    Publication number: 20210171943
    Abstract: Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein to the ZNF274 binding site is reduced relative to a control. The ZNF274 binding site comprises a polynucleotide having at least 90% sequence identify to SEQ ID NO: 1 or SEQ ID NO: 42. Further provided are DNA targeting systems that bind to a ZNF274 binding site or to a gene encoding a ZNF274 protein.
    Type: Application
    Filed: December 7, 2018
    Publication date: June 10, 2021
    Inventors: Stormy Chamberlain, Justin Cotney, Maéva Langouët, Marc Lalande
  • NEURONAL ENHANCERS
    Publication number: 20190247516
    Abstract: A delivery vehicle which comprises a nucleic acid construct, wherein the nucleic acid construct comprises (i) an enhancer which specifically drives gene expression in cells of the entorhinal cortex (ii) a promoter; and (iii) a therapeutic gene, wherein said enhancer, promoter and therapeutic gene are operatively linked, said enhancer and therapeutic gene are heterologous, and said delivery vehicle is suitable for delivery of the nucleic acid construct to the brain of a mammal.
    Type: Application
    Filed: November 6, 2018
    Publication date: August 15, 2019
    Inventors: Justin Cotney, Clifford Kentros, Stefan Blankvoort, Rajeevkumar Raveendran Nair