Abstract: Provided are certain derivatives of amphotericin B (AmB) characterized by reduced toxicity and retained anti-fungal activity. Certain of the derivatives are C16 urea derivatives of AmB. Certain of the derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain of the derivatives include C3? or C4? modifications of the mycosamine appendage of AmB. Also provided are methods of making AmB derivatives of the invention, pharmaceutical compositions comprising AmB derivatives of the invention, and methods of use of AmB derivatives of the invention.

Abstract: The present disclosure provides a packaging article. In an embodiment, the packaging article includes (A) a container having (i) a top wall and a bottom wall and (ii) a plurality sidewalls extending between the top wall and bottom wall. The walls define a compartment. The packaging article includes (B) an upper sheet in the compartment, the upper sheet composed of 3-dimensional random loop material (3DRLM). The upper sheet extends between and contacts two opposing sidewalls of the container. The packaging article includes (C) a lower sheet in the compartment, the lower sheet composed of 3DRLM. The lower sheet extends between and contacts two opposing sidewalls of the container. The two sheets are in opposing relation to each other. The packaging article includes (D) a product disposed between the upper sheet and the lower sheet.