Abstract: A fluid flow regulating mechanism designed particularly for use in connection with aerosolized drug delivery devices is disclosed. The mechanism includes a housing, planar elastic element, regulating element and positioning component. The elements of the device are configured in a manner such that a flow channel through the housing is opened or closed depending on the flow rate of fluid through a flow channel.

Abstract: A formulation of a drug in a liquid carrier is heated in a controlled fashion and then aerosolized. The aerosolized formulation comprises particles having an aerodynamic diameter in a range of about 0.5 to about 12 micrometers. The particles are inhaled into the lungs of a human patient thereby delivering drug to the patient. By heating the formulation prior to aerosolization, the viscosity of the formulation is reduced thereby improving delivery efficiency. Repeatability of aerosol formation is improved by pre-heating the solution to the same or substantially the same temperature for successive delivery events.