Abstract: Provided herein are systems and methods for carrying out high-throughput quantitative measurements of bulk mechanical properties of soft materials. The systems include a centrifuge, solid particles, and sample wells. In the systems and methods, samples comprising solid particles embedded in soft materials contained within sample wells are centrifuged in a series of increasing centrifugal speed increments, and a bulk mechanical property, such as fracture stress or elastic modulus, of each soft material is determined by monitoring the centrifugal force needed for the solid particles to fracture the soft material in each of the samples.