Patents by Inventor Justin GUNESCH

Justin GUNESCH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL-12 POLYPEPTIDES, IL-15 POLYPEPTIDES, IL-18 POLYPEPTIDES, CD8 POLYPEPTIDES, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20240066127
    Abstract: The present disclosure relates to cells capable of co-expressing one or any combination of T cell receptors (“TCR”), CD8 polypeptides, interleukin 12 (IL-12) polypeptides, interleukin 15 (IL-15) polypeptides, and/or interleukin 18 (IL-18) polypeptides, and the use thereof in adoptive cellular therapy (“ACT”). The present disclosure further provides for modified CD8 sequences, IL-12 sequences, IL-15 sequences, IL-18 sequences, vectors, compositions, transformed T cells, and associated methods thereof.
    Type: Application
    Filed: April 27, 2023
    Publication date: February 29, 2024
    Inventors: Justin GUNESCH, Melinda MATA, Mamta KALRA, Gagan BAJWA
  • MEMBRANE-BOUND IL-15, CD8 POLYPEPTIDES, CELLS, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20230348548
    Abstract: The present disclosure relates to cells capable of co-expressing T cell receptors (“TCR”) together with membrane-bound IL-15 polypeptides and/or CD8 polypeptides and the use thereof in adoptive cellular therapy. The present disclosure further provides for modified IL-15, IL-15R?, IL-15/IL-15R? fusion polypeptide, and IL-15R?/IL-15 fusion polypeptide sequences, vectors, and associated methods of making and using the same. The present disclosure further provides for modified CD8 sequences, vectors, and associated methods of making and using the same.
    Type: Application
    Filed: April 28, 2023
    Publication date: November 2, 2023
    Inventors: Justin GUNESCH, Mohammad HOSSAIN, Gagan BAJWA, Melinda MATA, Mamta KALRA
  • DOMINANT NEGATIVE TGFBETA RECEPTOR POLYPEPTIDES, CD8 POLYPEPTIDES, CELLS, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20230348561
    Abstract: The present disclosure relates to T cells capable of co-expressing T cell receptors (“TCR”) together with dominant negative TGF? Receptor (“dnTGF?R”) polypeptides and/or CD8 polypeptides and the use thereof in adoptive cellular therapy. The present disclosure further provides for dnTGF?R polypeptides, vectors, and associated methods thereof. The present disclosure further provides for modified CD8 polypeptides, vectors, and associated methods of making and using the same.
    Type: Application
    Filed: April 28, 2023
    Publication date: November 2, 2023
    Inventors: Erik FARRAR, Justin GUNESCH, Melinda MATA, Mohammad HOSSAIN, Mamta KALRA, Gagan BAJWA
  • MONOCYTE DEPLETION OF T CELLS POPULATIONS FOR T-CELL THERAPY
    Publication number: 20230089392
    Abstract: A method for producing an engineered T cell population includes obtaining a cell population containing a monocyte and a T cell, resting the obtained cell population on a surface, adhering the monocyte to the surface, retaining a non-adherent cell population, activating the non-adherent cell population, introducing a nucleic acid into the activated non-adherent cell population to obtain a transformed T cell, and expanding the transformed T cell to obtain the engineered T cell population.
    Type: Application
    Filed: September 19, 2022
    Publication date: March 23, 2023
    Inventors: Justin GUNESCH, Pooja MEHTA, Mamta KALRA