Abstract: A delivery device for a prosthetic mitral valve includes five sheaths and a handle. The first sheath is coupled to a first handle portion and is rotatable and bendable. The second sheath is coupled to a second handle portion and extends through the first sheath. The second sheath is bendable, rotatable and translatable relative to the first sheath. The third sheath is coupled to a third handle portion and extends through the first and second sheaths. The third sheath is translatable relative to the second sheath. The second handle portion is coupled to the first and third handle portions. The fourth sheath extends through the third sheath and forms part of a compartment to store the prosthetic valve. The fifth sheath extends through the fourth sheath to a tip and is coupled to a retaining sheath that closes the compartment to retain the valve in a collapsed condition.

Abstract: A medical device includes a surgical needle and an elongated suture. The suture has a first end attached to the surgical needle and a second end located away from the surgical needle. The suture includes a mesh wall and a plurality of pores extending through the mesh wall. At least some of the pores in the macroporous size range of greater than 200 microns and adapted to facilitate tissue integration through the mesh wall of the suture when introduced into a body. The suture is configured to resist a tensile load applied along an axial direction between the first and second ends of the elongated suture such that upon overloading the mesh wall collapses upon itself resulting in apparent suture elongation, collapsed diameter, and/or reduction in pore size.

Abstract: A delivery device for a prosthetic mitral valve includes five sheaths and a handle. The first sheath is coupled to a first handle portion and is rotatable and bendable. The second sheath is coupled to a second handle portion and extends through the first sheath. The second sheath is bendable, rotatable and translatable relative to the first sheath. The third sheath is coupled to a third handle portion and extends through the first and second sheaths. The third sheath is translatable relative to the second sheath. The second handle portion is coupled to the first and third handle portions. The fourth sheath extends through the third sheath and forms part of a compartment to store the prosthetic valve. The fifth sheath extends through the fourth sheath to a tip and is coupled to a retaining sheath that closes the compartment to retain the valve in a collapsed condition.

Abstract: A medical device includes a surgical needle attached to a mesh suture having anti-roping elements. The suture is constructed of a macroporous mesh wall that facilitates and allows tissue integration subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility. Advantageously, the anti-roping elements serve to maintain the desired construct of the mesh wall when undergoing axial tensile loads by resisting elongation and loss of outer mesh wall macroporosity, while still permitting a flattening of the suture with lateral loading.

Abstract: A medical device includes a surgical needle attached to a mesh suture having anti-roping elements. The suture is constructed of a flat macroporous mesh wall that facilitates and allows tissue integration subsequent to introduction to the body, thereby preventing suture pull-through and improving biocompatibility. Advantageously, the anti-roping elements serve to maintain the desired construct of the flat mesh wall when undergoing axial tensile loads by resisting elongation and loss of outer mesh wall macroporosity.