Patents by Inventor Justin Ichida

Justin Ichida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230098111
    Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a PIKFYVE antisense or inhibitory nucleic acid to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity and/or inhibiting the expression of PIKFYVE gene.
    Type: Application
    Filed: January 28, 2021
    Publication date: March 30, 2023
    Inventors: Justin Ichida, Uh Jin Lee, Manuel Santana
  • Publication number: 20230066380
    Abstract: Disclosed is a method of treating a subject who has a neurological disease. In one aspect, the method includes a step of administering an effective dose of a SYF2 antisense or inhibitory nucleic acid to a subject in need thereof, thereby restoring nuclear localization of TDP-43.
    Type: Application
    Filed: January 22, 2021
    Publication date: March 2, 2023
    Inventors: Justin Ichida, Gabriel Linares
  • Publication number: 20220073874
    Abstract: The disclosure relates methods for increasing the efficiency of cellular reprogramming of somatic cells and improving the maturity of the resulting cells.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 10, 2022
    Inventors: Justin Ichida, Kimberley N. Babos, Kate E. Galloway
  • Patent number: 10758545
    Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: September 1, 2020
    Assignee: University of Southern California
    Inventors: Justin Ichida, Shaoyu Lin, Yichen Li, Yingxiao Shi
  • Publication number: 20180161335
    Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 14, 2018
    Inventors: Justin Ichida, Shaoyu Lin, Yichen Li, Yingxiao Shi
  • Publication number: 20170044492
    Abstract: The present invention provides methods of transdifferentiation of somatic cells, e.g., a fibroblast, into a nociceptor cell, e.g., an induced nociceptor (iNociceptors) with characteristics of a typical nociceptor cell. The present invention also relates to an isolated population comprising iNociceptors, compositions, their use in the study of cellular and molecular mechanisms of peripheral pain generation and peripheral neuropathy, use in in vitro drug discovery assays, pain research, as their use in the treatment of nociceptive pain related diseases or disorders. In particular, the present invention relates to direct conversion of a somatic cell to an iNociceptor cell having nociceptor characteristics by increasing the protein expression of five nociceptor inducing factors selected from Asc11, Myt11, Isl2, Ngn1, Klf7 in a somatic cell, to convert the fibroblast to an iNociceptors which express the markers of adult nociceptors.
    Type: Application
    Filed: December 5, 2014
    Publication date: February 16, 2017
    Inventors: Clifford J. Woolf, Brian J. Wainger, Kevin Eggan, Isaac Chiu, Justin Ichida
  • Publication number: 20160115447
    Abstract: The present inventions relate to methods and compositions useful for improving the efficiency of inducing the generation of neurons from non-neuronal cell types, for example, by contacting the cell or cell culture medium with one or more agents which inhibit Activin and/or PLK1 signaling. Also disclosed are methods for promoting neuron survival, for example, by inhibiting Activin and/or PLK1 signaling, and methods for promoting the survival of intermediates in a cell differentiation pathway, for example, by inhibiting Activin and/or PLK1 signaling.
    Type: Application
    Filed: June 11, 2014
    Publication date: April 28, 2016
    Inventors: Andre BLUMENSTEIN, Justin ICHIDA, Kevin C. EGGAN, Lee L. RUBIN
  • Publication number: 20120021519
    Abstract: The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-?-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.
    Type: Application
    Filed: September 21, 2009
    Publication date: January 26, 2012
    Applicant: PRESIDENTS AND FELLOWS OF HARVARD COLLEGE
    Inventors: Justin Ichida, Joel Blanchard, Lee Rubin, Kevin Eggan, Kelvin Lam