Abstract: The present invention relates to formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar, a cellulose derivative, a glycol or sugar alcohol, optionally an alkali or alkaline salt and an amino acid; and formulations of dengue virus vaccine comprising at least one live, attenuated dengue virus or live, attenuated chimeric flavivirus, a buffer, a sugar of at least 150 mg/ml, a carrier, and optionally an alkali or alkaline salt and an amino acid.

Abstract: A system and method for visually warning a person of a dangerous condition related to the proximity of the person to a machine is provided. The system includes a transmitter system located on the machine, a locator for being carried by the person, an algorithm performed at the transmitter for determining coordinates of the locator relative to the transmitter system, data input into the controller defining one or more safety zones around the machine, a warning indicator for generating a signal when the locator enters any of the one or more safety zones, and a lamp associated with the person. The lamp may be a spot lamp for illuminating the area around the person, and it may also include one or more warning lamps associated with the warning indicator such that the one or more warning lamps are illuminated when the locator enters either of the safety zones.

Abstract: An example includes a first box half with a top first half bushing, a bottom first half bushing, and a second box half with a top second half bushing, and a bottom second half bushing, and the first box half and the second box half are separate and are affixed to one another by a hinge with a rotating axis. The box in a closed position provides a way to shield and protect a wire splice.

Abstract: An exercise device has a generally spheroidal body having a top, a bottom, a first side, a second side, a front, and a rear, a first handle extending outwardly from the first side, the first handle comprising a grip spaced from the body; and a second handle extending outwardly from the second side, the second handle comprising a grip spaced from the body, wherein the first and second handles extend upwardly towards the top of said body at an angle relative to a horizontal plane through the body. Exercise devices of different masses may have different sized bodies, but have approximately the same total width from handle to handle.

Abstract: An air purification system for use with rail car HVAC system to remove or destroy harmful pathogens in the air. The air purification system has a housing with an inlet, an outlet, and a passageway extending between the inlet and the outlet. An intense field generator and filter is used to charge any particles in the air and remove them from the air flow. An ultraviolet radiation source is positioned to direct ultraviolet illumination into the passageway. Finally, a dielectric barrier discharge unit having a high voltage electrode coupled to a dielectric barrier and a ground electrode spaced apart from the high voltage electrode is used to form a low temperature plasma chamber is in communication with the passageway so that the ions created in the plasma chamber will attach to and destroy any remaining particles in the air flow.

Abstract: An air purification system for use in a given location to remove or destroy harmful pathogens in the air. The air purification system has a housing with an inlet, an outlet, and a passageway extending between the inlet and the outlet. An intense field generator and filter is used to charge any particles in the air and remove them from the air flow. Finally, a dielectric barrier discharge unit having a high voltage electrode coupled to a dielectric barrier and a ground electrode spaced apart from the high voltage electrode is used to form a low temperature plasma chamber is in communication with the passageway so that the ions created in the plasma chamber will attach to and destroy any remaining particles in the air flow.

Abstract: New and improved methods and systems for modeling the performance of selected company metrics. Multiple, non-traditional sets of objective data along with mathematical analytical techniques are used to provide transparency and visibility into company performance relating to the particular metrics. Company inflection points and changes in strategy may be identified. The performance of a company and/or the performance of a selected industry or industry sector may be analyzed.

Abstract: The invention provides a component formed of an aluminum alloy for use in a vehicle, for example an automotive vehicle component requiring high strength, light-weight, and a complex three-dimensional shape, and a method of manufacturing the component. The method begins by providing a blank formed of an aluminum alloy which is already solution heat treated and tempered, and thus has a temper designation of about T4. The method further includes heating the blank to a temperature of 150° C. to 350° C., preferably 190° C. to 225° C. The method next includes quickly transferring the blank to a hot or warm forming apparatus, and stamping the blank to form the complex three-dimensional shape. Immediately after the forming step, the component has a temper designation of about T6, but preferably not greater than T6, and thus is ready for use in the vehicle without any post heat treatment or machining.

Abstract: The present invention relates generally to laser welding in the manufacture of sheet metal components, such as for example automobile components. More particularly, the present invention relates to a process and a system for forming a localized anti-corrosion surface layer along a laser welded joint (weld bead), subsequent to the laser welding together of sheet metal plates having an anti-corrosion surface layer pre-coat.

Abstract: A curable film-forming composition is provided, comprising: (a) a polymeric binder comprising reactive functional groups; (b) a curing agent comprising functional groups that are reactive with the reactive functional groups of (a); and (c) a polysiloxane resin comprising aromatic functional groups and terminal active hydrogen groups. In certain examples of the present invention, the polymeric binder (a) comprises an acrylic polyol prepared from a monomer mixture comprising a hydroxyl functional monomer, and the curable film-forming composition further comprises a rheology modifier comprising: (1) a non-aqueous dispersion of an internally crosslinked organic polymer; (2) a silica dispersion; and/or (3) a reaction product of an amine and an isocyanate. Also provided are coated substrates that include the curable film-forming compositions described above and methods for forming a composite coating on a substrate.

Abstract: The present application provides fibers made from recombinant hagfish intermediate filament proteins. Methods of expressing and purifying the proteins, and methods of creating the fibers, are likewise disclosed. The method of purifying protein yields larger quantities of hagfish protein than have been previously achieved, and the fibers have the highest mechanical properties yet recorded for recombinant hagfish protein fibers.

Abstract: A method of spectroscopically measuring percent glycated hemoglobin or a glycated hemoglobin:total hemoglobin ratio in a biological sample is disclosed. The method includes the use of a turbidity normalization algorithm to normalize the total hemoglobin concentration calculated from the spectroscopic measurements to substantially remove any turbidity interference therefrom. The turbidity normalization eliminates the negative bias observed with intralipid/lipemia and thus provides a glycated hemoglobin assay with no significant interference from intralipid/lipemia.

Abstract: A method of spectroscopically measuring percent glycated hemoglobin or a glycated hemoglobin:total hemoglobin ratio in a biological sample is disclosed. The method includes the use of a turbidity normalization algorithm to normalize the total hemoglobin concentration calculated from the spectroscopic measurements to substantially remove any turbidity interference therefrom. The turbidity normalization eliminates the negative bias observed with intralipid/lipemia and thus provides a glycated hemoglobin assay with no significant interference from intralipid/lipemia.

Abstract: An air purification system for use with rail car HVAC system to remove or destroy harmful pathogens in the air. The air purification system has a housing with an inlet, an outlet, and a passageway extending between the inlet and the outlet. An intense field generator and filter is used to charge any particles in the air and remove them from the air flow. An ultraviolet radiation source is positioned to direct ultraviolet illumination into the passageway. Finally, a dielectric barrier discharge unit having a high voltage electrode coupled to a dielectric barrier and a ground electrode spaced apart from the high voltage electrode is used to form a low temperature plasma chamber is in communication with the passageway so that the ions created in the plasma chamber will attach to and destroy any remaining particles in the air flow.

Abstract: A three-dimensional image quality indicator suitable for assessing the quality of a CT scan includes a pyramidal structure having a base, an apex, and a plurality of triangular faces extending from the base to the apex; at least two grooves in each triangular face, each groove tapering from a wide end at the base to a narrow end at the apex; and a land between each pair of adjacent grooves in each triangular face, each land tapering from the base to the apex. When a two-dimensional slice is taken in a plane parallel to the base of the pyramidal structure, the grooves are observable at the edges of the structure. The smallest observable groove width provides a measure of CT resolution.

Abstract: Transgenic silkworms stably expressing synthetic spider silk genes or composite silkworm/spider silk genes are disclosed. The exogenous spider silk genes are stably intergrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic spider silk proteins and composite spider silk-silkworm genes and proteins are provided. The expression of exogenous spider silk genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/spider silk fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.

Abstract: A bumper system including a bumper beam being cast from metal having a front panel and a back panel, extending between a first bumper beam end and a second bumper beam end. A plurality of reinforcing ribs integrally cast with the bumper beam extends between the front panel and the back panel defining a non-uniform cross-sectional profile along a portion of the bumper beam. The front panel includes a front center portion disposed between a pair of front side portions. The back panel includes a back center portion disposed between a pair of back side portions. The front center portion has a front center portion thickness greater than a back center portion thickness. Each of the front side portions has a front side portion thickness being less than a back side portion thickness of adjacent one of the back side portions. Method of manufacturing the bumper system is provided.

Abstract: An air purification system for use with rail car HVAC system to remove or destroy harmful pathogens in the air. The air purification system has a housing with an inlet, an outlet, and a passageway extending between the inlet and the outlet. An intense field generator and filter is used to charge any particles in the air and remove them from the air flow. An ultraviolet radiation source is positioned to direct ultraviolet illumination into the passageway. Finally, a dielectric barrier discharge unit having a high voltage electrode coupled to a dielectric barrier and a ground electrode spaced apart from the high voltage electrode is used to form a low temperature plasma chamber is in communication with the passageway so that the ions created in the plasma chamber will attach to and destroy any remaining particles in the air flow.

Abstract: Transgenic silkworms stably expressing hagfish thread keratin genes or composite silkworm/hagfish thread keratin genes are disclosed. The exogenous hagfish thread keratin genes are stably integrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic hagfish thread keratin proteins and composite hagfish thread keratin-silkworm genes and proteins are provided. The expression of exogenous hagfish thread keratin genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/hagfish thread keratin fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.