Abstract: Biological information and medical knowledge information are used for self-learning clinical intelligence. Medical knowledge information is assembled. Medical rules are generated based on the medical knowledge. The medical rules can be generated probabilistically. A plurality of risk models can be learned. The plurality of risk models are associated with a given disease based on patient attributes. A medical probabilistic rule graph is built based on the medical rules and the plurality of risk models. The building of the medical probabilistic rule graph is based on ordering the medical rules. Attributes from an individual patient are applied to the medical probabilistic rule graph. A diagnosis for the individual is generated from the attributes applied to the medical probabilistic rule graph. A treatment for the individual can be generated from the attributes applied to the medical probabilistic rule graph.