Abstract: Systems, methods, and apparatus are provided for real-time adjustment of image quality parameters. The system includes a controller configured to: acquire an image frame, having a fixed-pixel region that defines a region-of-interest, from one or more imaging devices; apply image processing techniques to determine a modified fixed-pixel region that excludes non-relevant object pixels; alter one or more image quality parameters based on statistics of pixels in the modified fixed-pixel region; and provide the altered one or more image quality parameters to the one or more imaging devices for use with subsequent image frames; wherein the one or more imaging devices produce an image that is tuned, based on the altered one or more image quality parameters, to the portions of the image in the region-of-interest that does not include the non-relevant object pixels.