Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human ?-lactalbumin.

Abstract: Techniques are described for forming a gradient index (GRIN) lens for propagating an electromagnetic wave comprising receiving, by a manufacturing device having one or more processors, a model comprising data specifying a plurality of layers, wherein at least one layer of the plurality of layers comprises an arrangement of one or more volume elements comprising a first dielectric material and a second dielectric material, wherein the at least one layer of the plurality of layers has a dielectric profile that is made up of a plurality of different effective dielectric constants of the volume elements in the layer, and generating, with the manufacturing device by an additive manufacturing process, the GRIN lens based on the model.

Abstract: Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2).

Abstract: Compositions comprising an antigen, a carbohydrate, and a metabolizable oil, methods of administering such compositions to a subject, methods of making such compounds, and related compositions, methods, and uses.

Abstract: Embodiment herein provides an Infrastructure article (101) and method thereof for synchronizing blinks of infrastructure articles in a mesh network. The method includes detecting an expiry of a sync timer counted by a real time clock (RTC) and determining whether a charge level of a battery (105) of the infrastructure article (101) meets a battery charge threshold. When the charge level of the battery (105) of the infrastructure article (101) meets the battery charge threshold, the method includes establishing a connection with other infrastructure article and/or an infrastructure article server (200) in the mesh network, and sending a time to synchronize blink of the at least one light source (106) to all other infrastructure articles in the mesh network. When the charge level of the battery (105) of the infrastructure article (101) does not meet the battery charge threshold, the method includes resetting the sync timer, and initiating a count of the sync timer.

Abstract: Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2).

Abstract: Provided herein are compositions, systems, kits, and methods of using a composition comprising at least a portion of an Anti-Mullerian Hormone Receptor Type II extracellular domain (AMHR-ED), and an adjuvant comprising: i) squalene oil, ii) a non-ionic surfactant (e.g., Tween 80), iii) an emulsifier (e.g., sorbitan trioleate), and iv) a buffer (e.g., citrate buffer). In certain embodiments, such compositions are administered to a female subject to treat or prevent ovarian or endometrial cancer (e.g., by inducing expression of anti-AMHR2-ED IgG antibodies by the subject in vivo).

Abstract: A cabin air quality monitoring system including a communications interface configured to receive snapshot information representing in-cabin air quality of a vehicle, a memory configured to store the snapshot information received by the communications interface and a processing circuitry configured to batch the snapshot information stored to the memory to form batched snapshot information, to execute, using the batched snapshot information as an input, a trained machine learning model to obtain a model output that includes cabin air filter replacement information, and to transmit, via the communications interface, the model output to computing hardware of the vehicle.

Abstract: Compositions comprising an antigen, a carbohydrate, and a metabolizable oil, methods of administering such compositions to a subject, methods of making such compounds, and related compositions, methods, and uses.

Abstract: Provided herein are anti-Anti-Miillerian Hormone Receptor 2 (AMHR2) antibodies and methods of using such antibodies, for example, in the treatment of cancer.

Abstract: Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human ?-lactalbumin.

Abstract: At least some embodiments of the present disclosure directs to a method for processing an input image having an embedded element, comprising the steps of: computing one or more histograms of the input image; identifying a range of interest in one of the one or more histograms; and determining, by the processor, a threshold based on the range of interest. In some embodiments, a computing device processes the input image using the threshold to generate an output image.

Abstract: The present disclosure is directed to retroreflective articles to increase visibility of a vehicle, wherein the retroreflective article comprises one or more retroreflective markings arranged in a given pattern and at least a portion of the article has a curvature.

Abstract: The disclosure is directed to an article, such as a pathway article or a sheeting. The article includes a physical surface having a code embodied thereon. The code is associated with pathway information in transaction data stored by a blockchain managed by a consensus network of node. The pathway information indicates one or more characteristics of a vehicle pathway, wherein the pathway information provides at least one of: information descriptive of at least a portion of the vehicle pathway, or vehicle operation instructions associated with the portion of the vehicle pathway.

Abstract: An article includes a substrate having a physical surface, a multi-dimensional machine-readable code embodied on the physical surface, wherein the multi-dimensional machine-readable optical code includes a static data (SD) optical element set and a dynamic lookup data (DLD) optical element set. Each of the SD and the DLD sets are embodied on the physical surface. The DLD optical element set encodes a look-up value that references dynamically changeable data, wherein the SD optical element set encodes static data that does not reference other data. The DLD optical element set is not decodable at the distance greater than the threshold distance.

Abstract: Compositions comprising an antigen, a carbohydrate, and a metabolizable oil, methods of administering such compositions to a subject, methods of making such compounds, and related compositions, methods, and uses.

Abstract: Provided herein are methods, kits and compositions for the treatment and/or prevention of ovarian cancer through the induction of an immune response against Anti-Mullerian Hormone Receptor, Type II (AMHR2).

Abstract: In some examples, a computing device includes one or more computer processors, a communication device, and a memory comprising instructions that cause the one or more computer processors to: receive, using the communication device and from a set of vehicles, different sets of infrastructure data for a particular infrastructure article that is proximate to each respective vehicle of the set of vehicles, wherein each respective vehicle in the set of vehicles comprises at least one infrastructure sensor that generates infrastructure data descriptive of infrastructure articles that are proximate to the respective vehicle; determine, based at least in part on the different sets of infrastructure data for the particular infrastructure article from each respective vehicle of the set of vehicles, a quality metric for the infrastructure article; and perform at least one operation based at least in part on the quality metric for the infrastructure article.

Abstract: In some examples, an optically active article includes a retroreflective substrate; and at least one security element disposed at the retroreflective substrate; an article message disposed at the retroreflective substrate, and wherein the at least one security element comprises validation information that is detectable outside a visible light spectrum, and wherein a combination of the article message and the validation information of the at least one security element indicates whether the optically active article is counterfeit.