Abstract: A valve actuation system comprises a first arm having a first arm contact surface and operatively connected to a valve actuation motion. A second arm having a second arm contact surface is operatively connected to the at least one engine valve. A discrete lost motion device is provided that is controllable between a first, motion conveying state and a second, motion absorbing state. The discrete lost motion devices comprises a plunger contact surface and a housing contact surface. The housing contact surface is configured to engage one of the first or second arm contact surfaces, and the plunger contact surface is configured to engage another of the first and the second arm contact surfaces. The first and second arm contact surfaces, the housing contact surface and the first plunger contact surface are configured to support the discrete lost motion device between the first arm and the second arm.

Abstract: The present anti-ballistic shelter is a reinforced unit configured to comply with both ISO standards for size and weight, and with the U.S. Department of State Certification Standard for Forced Entry and Ballistic Resistance of Structural Systems. Each end and side wall of the unit is reinforced with wall studs that penetrate the unit's structural framework. Even though these wail studs are welded into place, penetration of the wall studs into the framework ensures acceptable blast, ballistic, and forced entry resistance even if the welds are flawed.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: Enclosed structures, such as guard towers, are provided which are designed to be easily transportable, constructed easily onsite and erected in a manner which produces an exceptionally blast resistant structure that is also advantageously designed for positioning within a perimeter wall. In particular, in some embodiments, the guard towers have a pentagon shape and are comprised of a plurality of composite panels. Each panel is able to be constructed onsite. The panels typically have a rectangular shape with at least one half of the panel constructed as a solid composite of concrete and metal. Once the panels are constructed, the panels are erected and arranged in a pentagon shape. The panels are bolted together with the use of vertical face connections. These connections provide better structural integrity, retained over time, particularly after subjection to a blast. In addition, the pentagon shape provides improved safety when positioned along a perimeter wall.

Abstract: A Hardened Alternative Trailer System (HATS) is described, including methods of producing same. HATS has superior blast, ballistic and forced entry protection properties, relative to existing structures, due to particular features of frame design and construction methods. Furthermore, HATS is a low-cost reinforced ISO container suitable for field and/or remote fabrication and meets blast, ballistic/projectile and/or forced entry threats such as the U.S. Department of State Certification Standard SD-STD-01.01, Revision G.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: Enclosed structures, such as guard towers, are provided which are designed to be easily transportable, constructed easily onsite and erected in a manner which produces an exceptionally blast resistant structure that is also advantageously designed for positioning within a perimeter wall. In particular, in some embodiments, the guard towers have a pentagon shape and are comprised of a plurality of composite panels. Each panel is able to be constructed onsite. The panels typically have a rectangular shape with at least one half of the panel constructed as a solid composite of concrete and metal. Once the panels are constructed, the panels are erected and arranged in a pentagon shape. The panels are bolted together with the use of vertical face connections. These connections provide better structural integrity, retained over time, particularly after subjection to a blast. In addition, the pentagon shape provides improved safety when positioned along a perimeter wall.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: In one embodiment, a flashing system is provided for fortifying seams between a first blast, ballistic, and forced entry resistant shelter module and a second blast, ballistic, and forced entry resistant shelter module. The system includes a first side flashing assembly for fortifying a first side seam between the first blast, ballistic, and forced entry resistant shelter module and the second blast, ballistic, and forced entry resistant shelter module, a top flashing assembly for fortifying a top seam between the first blast, ballistic, and forced entry resistant shelter module and the second blast, ballistic, and forced entry resistant shelter module, and a second side flashing assembly for fortifying a second side seam between the first blast, ballistic, and forced entry resistant shelter module and the second blast, ballistic, and forced entry resistant shelter module.

Abstract: The modular anti-ballistic shelter system includes two end units and, optionally, additional middle units for a wider structure. End and middle units may also stack atop each other for multi-story structures. Each unit is configured to comply with both ISO standards for size and weight, and with the U.S. Department of State Certification Standard for Forced Entry and Ballistic Resistance of Structural Systems. Each exterior wall of each end unit and each middle unit is reinforced with wall studs that penetrate the unit's structural framework of beams and frames. Even though these wall studs are welded into place, penetration of the wall studs into the beams and frames ensures acceptable blast, ballistic, and forced entry resistance even if the welds are flawed.

Abstract: In one embodiment, a flashing system is provided for fortifying seams between a first blast, ballistic, and forced entry resistant shelter module and a second blast, ballistic, and forced entry resistant shelter module. The system includes a first side flashing assembly for fortifying a first side seam between the first blast, ballistic, and forced entry resistant shelter module and the second blast, ballistic, and forced entry resistant shelter module, a top flashing assembly for fortifying a top seam between the first blast, ballistic, and forced entry resistant shelter module and the second blast, ballistic, and forced entry resistant shelter module, and a second side flashing assembly for fortifying a second side seam between the first blast, ballistic, and forced entry resistant shelter module and the second blast, ballistic, and forced entry resistant shelter module.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V) and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: The modular anti-ballistic shelter system includes two end units and, optionally, additional middle units for a wider structure. End and middle units may also stack atop each other for multi-story structures. Each unit is configured to comply with both ISO standards for size and weight, and with the U.S. Department of State Certification Standard for Forced Entry and Ballistic Resistance of Structural Systems. Each exterior wall of each end unit and each middle unit is reinforced with wall studs that penetrate the unit's structural framework of beams and frames. Even though these wall studs are welded into place, penetration of the wall studs into the beams and frames ensures acceptable blast, ballistic, and forced entry resistance even if the welds are flawed.

Abstract: The modular anti-ballistic shelter system includes two end units and, optionally, additional middle units for a wider structure. End and middle units may also stack atop each other for multi-story structures. Each unit is configured to comply with both ISO standards for size and weight, and with the U.S. Department of State Certification Standard for Forced Entry and Ballistic Resistance of Structural Systems. Each exterior wall of each end unit and each middle unit is reinforced with wall studs that penetrate the unit's structural framework of beams and frames. Even though these wall studs are welded into place, penetration of the wall studs into the beams and frames ensures acceptable blast, ballistic, and forced entry resistance even if the welds are flawed.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V) and (VI). Some bromdomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: The present anti-ballistic shelter is a reinforced unit configured to comply with both ISO standards for size and weight, and with the U.S. Department of State Certification Standard for Forced Entry and Ballistic Resistance of Structural Systems. Each end and side wall of the unit is reinforced with wall studs that penetrate the unit's structural framework. Even though these wail studs are welded into place, penetration of the wall studs into the framework ensures acceptable blast, ballistic, and forced entry resistance even if the welds are flawed.

Abstract: The modular anti-ballistic shelter system includes two end units and, optionally, additional middle units for a wider structure. End and middle units may also stack atop each other for multi-story structures. Each unit is configured to comply with both ISO standards for size and weight, and with the U.S. Department of State Certification Standard for Forced Entry and Ballistic Resistance of Structural Systems. Each exterior wall of each end unit and each middle unit is reinforced with wall studs that penetrate the unit's structural framework of beams and frames. Even though these wall studs are welded into place, penetration of the wall studs into the beams and frames ensures acceptable blast, ballistic, and forced entry resistance even if the welds are flawed.

Abstract: A Hardened Alternative Trailer System (HATS) is described, including methods of producing same. HATS has superior blast, ballistic and forced entry protection properties, relative to existing structures, due to particular features of frame design and construction methods. Furthermore, HATS is a low-cost reinforced ISO container suitable for field and/or remote fabrication and meets blast, ballistic/projectile and/or forced entry threats such as the U.S. Department of State Certification Standard SD-STD-01.01, Revision G.