Patents by Inventor Justin M. Wolfe

Justin M. Wolfe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric peptides for antisense delivery
    Patent number: 12370261
    Abstract: Provided herein are oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates, the chimeric peptides and peptide-oligonucleotide-conjugates comprising at least two cell-penetrating peptides, wherein at least one of the cell-penetrating peptides is an amphipathic peptide and at least one of the cell-penetrating peptides is an oligoarginine peptide. The oligoarginine peptide comprises the sequence [(RYzR)x] (SEQ ID NOs: 15-18), wherein R is arginine, Y is independently selected from aminohexanoic acid (X) or ?-alanine (B). Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates comprising at least two cell-penetrating peptides, wherein at least one of the cell-penetrating peptides is an amphipathic peptide and at least one of the cell-penetrating peptides is an oligoarginine peptide described herein.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: July 29, 2025
    Assignees: Sarepta Therapeutics, Inc., Massachusetts Institute of Technology
    Inventors: Bradley L. Pentelute, Colin M. Fadzen, Rebecca L. Holden, Justin M. Wolfe, Zi-Ning Choo, Monica Yao, Gunnar J. Hanson
  • Cell-penetrating peptides for antisense delivery
    Patent number: 12138312
    Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: November 12, 2024
    Assignees: Sarepta Therapeutics, Inc., Massachusetts Institute of Technology
    Inventors: Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
  • Cell-Penetrating Peptides For Antisense Delivery
    Publication number: 20200316210
    Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Application
    Filed: October 17, 2018
    Publication date: October 8, 2020
    Inventors: Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute
  • BICYCLIC PEPTIDE OLIGONUCLEOTIDE CONJUGATES
    Publication number: 20200237922
    Abstract: Provided herein are oligonucleotides, bicyclic peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
    Type: Application
    Filed: October 17, 2018
    Publication date: July 30, 2020
    Inventors: Justin M. Wolfe, Colin M. Fadzen, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute