Abstract: A clip insertion system is disclosed inserting and/or removing clips from rail plates. The clip insertion system described herein may comprise a hand tool that positions and inserts a clip into a rail plate that is attached to the railroad tie. The clip secures the steel rail to the tie. This invention represents a significant improvement over existing clip setting hand tools by improving useability, reducing safety risks, and increasing efficiency in the process/method of securing the rail using clips and/or other clip-based technologies. This system also provides and improved method of moving and positioning the tool as it is moved to successive clip insertion locations.

Abstract: The present invention provides for oral care systems comprising: an appliance comprising a first and second plurality of nozzles, the appliance configured to be held in the mouth of a user with the first and second plurality of nozzles in fluid communication with one or more surfaces of the user's oral cavity; a source of gas; a source of liquid; and a fluid controller for directing entrained fluid to the appliance. Also provided are methods of cleaning, or otherwise providing benefits to, one or more surfaces of the oral cavity using a system of the present invention.

Abstract: Modeling human disease in cultured cells requires efficient modification of one or both alleles depending on dominant or recessive inheritance. Editing of single nucleotide variants (SNVs) is particularly challenging because the modified allele contains only one mismatch relative to the target sequence and is subject to re-cleavage and damage by the nuclease. The donor nucleic acids provided herein are, inter alia, useful for editing genome sequences by introducing precise changes in a target site in the presence of the donor sequence and minimizing re-cleavage of the donor nucleic acid by nucleases. By doing so, the compositions and methods provided herein produce modified genomic sequences resistant to nuclease cleavage.

Abstract: The present invention provides for oral care systems comprising: an appliance comprising a first and second plurality of nozzles, the appliance configured to be held in the mouth of a user with the first and second plurality of nozzles in fluid communication with one or more surfaces of the user's oral cavity; a source of gas; a source of liquid; and a fluid controller for directing entrained fluid to the appliance. Also provided are methods of cleaning, or otherwise providing oral care benefits to, one or more surfaces of the oral cavity using a system of the present invention.

Abstract: The present invention provides for oral care systems comprising: an appliance comprising a first and second plurality of nozzles, the appliance configured to be held in the mouth of a user with the first and second plurality of nozzles in fluid communication with one or more surfaces of the user's oral cavity; a source of gas; a source of liquid; and a fluid controller for directing entrained fluid to the appliance. Also provided are methods of cleaning, or otherwise providing benefits to, one or more surfaces of the oral cavity using a system of the present invention.

Abstract: An oral care system that provides a beneficial effect to an oral cavity of a mammal by using a liquid effective for providing the beneficial effect, where the system includes means for directing the liquid onto a plurality of surfaces of the oral cavity, means for providing the liquid to the means for directing the liquid onto the surfaces of the oral cavity, means for providing reciprocation of the liquid over the plurality of surfaces under conditions effective to provide the beneficial effect; and a reservoir for containing the liquid.

Abstract: A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a handle, a neck, and a head, where the head includes a cleaning component including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front and rear sealing membranes, inner side walls and a base inner wall, and where the inner side walls each include a plurality of openings, the device further including a first manifold and a second manifold, a first port and a second port for conveying liquid; and means for providing an effective seal of the device within the oral cavity.

Abstract: An oral care device suitable for use in providing a beneficial effect to an oral cavity of a mammal, which device includes means for providing reciprocation of a liquid effective for providing the beneficial effect of the oral cavity when the liquid is contacted with a plurality of surfaces thereof under conditions effective to provide the beneficial effect.

Abstract: A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front, rear and base inner walls of the device and the front and rear inner walls each include a plurality of openings, the devices further including a first manifold and a second manifold, a first port and a second port.

Abstract: A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a handle, a neck, and a head, where the head includes a cleaning component including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front and rear sealing membranes, inner side walls and a base inner wall, and where the inner side walls each include a plurality of openings, the device further including a first manifold and a second manifold, a first port and a second port for conveying liquid; and means for providing an effective seal of the device within the oral cavity.

Abstract: An oral care system that provides a beneficial effect to an oral cavity of a mammal by using a liquid effective for providing the beneficial effect, where the system includes means for directing the liquid onto a plurality of surfaces of the oral cavity, means for providing the liquid to the means for directing the liquid onto the surfaces of the oral cavity, means for providing reciprocation of the liquid over the plurality of surfaces under conditions effective to provide the beneficial effect; and a reservoir for containing the liquid.

Abstract: An oral care system that provides a beneficial effect to an oral cavity of a mammal by using a liquid effective for providing the beneficial effect, where the system includes means for directing the liquid onto a plurality of surfaces of the oral cavity, means for providing the liquid to the means for directing the liquid onto the surfaces of the oral cavity, means for providing reciprocation of the liquid over the plurality of surfaces under conditions effective to provide the beneficial effect; and a reservoir for containing the liquid.

Abstract: A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front, rear and base inner walls of the device and the front and rear inner walls each include a plurality of openings, the devices further including a first manifold and a second manifold, a first port and a second port; and means for providing an effective seal of the device within the oral cavity.

Abstract: A device for directing a liquid onto a plurality of surfaces of the oral cavity, the device including a chamber for maintaining the liquid proximate the surfaces, where the chamber is defined by front, rear and base inner walls of the device and the front and rear inner walls each include a plurality of openings, the devices further including a first manifold and a second manifold, a first port and a second port; and means for providing an effective seal of the device within the oral cavity.

Abstract: An oral care device suitable for use in providing a beneficial effect to an oral cavity of a mammal, which device includes means for providing reciprocation of a liquid effective for providing the beneficial effect of the oral cavity when the liquid is contacted with a plurality of surfaces thereof under conditions effective to provide the beneficial effect.

Abstract: The invention includes a toothbrush including a toothbrush handle and a toothbrush head having an end proximal a toothbrush handle, an end distal to the toothbrush handle, a dorsal surface for holding at least one toothbrush bristle, a ventral surface opposite the dorsal surface, first and second sides disposed between the dorsal and ventral surfaces of the toothbrush head, and a plurality of gum cushions disposed on each of the sides of the toothbrush head, where the height of the respective gum cushions tapers from the proximal end of the toothbrush head to the distal end of the toothbrush head.

Abstract: An oral care device suitable for use in providing a beneficial effect to an oral cavity of a mammal, which device includes means for providing reciprocation of a liquid effective for providing the beneficial effect of the oral cavity when the liquid is contacted with a plurality of surfaces thereof under conditions effective to provide the beneficial effect.