Abstract: The present invention relates to compositions of recombinant polynucleic acid or RNA constructs comprising a first RNA sequence, a second RNA sequence, and a linker RNA sequence, wherein the linker RNA links the first RNA sequence and the second RNA sequence. In addition, linkers that enhance the cleavage of recombinant RNA constructs are described. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to compositions and methods for modulating expression of genes, comprising recombinant polynucleic acid or RNA constructs comprising a first RNA sequence encoding a gene of interest, and a second RNA sequence comprising at least two genetic elements that modulate expression of one or more target RNAs. The recombinant RNA constructs described herein induce an immune response in a human cell that is lower than the immune response induced by a corresponding recombinant RNA construct comprising the first RNA sequence encoding a gene of interest and a corresponding second RNA sequence comprising at most one of the at least two genetic elements. Also disclosed herein is the use of the compositions in treating diseases and in modulating expression of two or more genes.

Abstract: The present invention relates to a mRNA and a therapeutic composition thereof for use in a method of treating lower urinary tract symptoms.

Abstract: Dispensing units for dispensing items, such as in a healthcare facility, are linked in a network. The dispensing units use a fingerprint to authenticate users. The fingerprints on a short list reflect recent authorization, and permit access without other identifying information. Dispensing units in the network may use different fingerprint scanning technologies, but are made compatible by enrolling fingerprints using the different technologies. Two or more reference fingerprints may be stored at a dispensing unit, permitting either a primary fingerprint or alternate fingerprint to gain access to that dispensing unit. During enrollment of a user, fingerprints for a user may be “fast tracked” for registration based upon a quality determination.

Abstract: Dispensing units for dispensing items, such as in a healthcare facility, are linked in a network. The dispensing units use a fingerprint to authenticate users. The fingerprints on a short list reflect recent authorization, and permit access without other identifying information. Dispensing units in the network may use different fingerprint scanning technologies, but are made compatible by enrolling fingerprints using the different technologies. Two or more reference fingerprints may be stored at a dispensing unit, permitting either a primary fingerprint or alternate fingerprint to gain access to that dispensing unit. During enrollment of a user, fingerprints for a user may be “fast tracked” for registration based upon a quality determination.