Abstract: The invention provides a formulation and method for the treatment of urinary system disorders, wherein the formulation comprises a controlled release drug delivery system for intravesicular administration to a patient. Controlled release microparticles in the formulation are comprised of a pharmacologically active agent and a controlled release carrier, where the microparticles are buoyant in urine. Microparticle buoyancy in urine ensures that the formulation continues to release the active agent into a patient's bladder throughout the duration of an extended drug delivery time period. Methods of treating urinary system disorders by intravesicular administration of the microparticle formulation to a subject are also provided, and include methods of treating urinary system infections, bladder cancer, incontinence, and other urinary system disorders.

Abstract: Armored critical incident vehicles and methods of use are disclosed. In an aspect, an armored critical incident vehicle useful for protecting and deploying first responders (e.g., SWAT team members) comprises a tracked multi-terrain loader having an enclosed, armored cab and vehicle loader arms and an armored deployment platform attaching to the tracked multi-terrain loaded at the vehicle loader arms. The armored deployment platform has an armored vertical face and an angled deflection plate to provide protection from ballistics from the front and from above.