Patents by Inventor Justin S. Cisar

Justin S. Cisar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAGL INHIBITORS
    Publication number: 20240018120
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 12, 2021
    Publication date: January 18, 2024
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • CRYSTALLINE FORMS OF A MAGL INHIBITOR
    Publication number: 20230357190
    Abstract: Described herein is new crystalline forms of the MAGL inhibitor 1,1,1,3,3,3-Hexafluoropropan-2-yl (S)-1-(pyridazin-3-ylcarbamoyl)-6-azaspiro[2.5]octane-6-carboxylate.
    Type: Application
    Filed: May 3, 2023
    Publication date: November 9, 2023
    Inventors: Thomas VETTER, John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne V. MOODY, Michael B. SHAGHAFI
  • CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20230312499
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Application
    Filed: November 8, 2022
    Publication date: October 5, 2023
    Inventors: Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Micah J. NIPHAKIS, Jae Won CHANG, Kenneth M. LUM, Benjamin F. CRAVATT
  • Carbamate compounds and methods of making and using same
    Patent number: 11530189
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: December 20, 2022
    Assignees: H. LUNDBECKA/S, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M. Lum, Benjamin F. Cravatt
  • MAGL inhibitors
    Patent number: 11434222
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Grant
    Filed: November 11, 2021
    Date of Patent: September 6, 2022
    Assignee: H. LUNDBECK A/S
    Inventors: John J. M. Wiener, Cheryl A. Grice, Daniel J. Buzard, Justin S. Cisar, Olivia Delene Weber, Amy Allan, Nicholas Raffaele, Jeanne Moody, Michael B. Shaghafi
  • ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME
    Publication number: 20220213074
    Abstract: Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.
    Type: Application
    Filed: May 13, 2020
    Publication date: July 7, 2022
    Inventors: Cheryl A. GRICE, Jeanne V. MOODY, Daniel J. BUZARD, Justin S. CISAR
  • MAGL INHIBITORS
    Publication number: 20220153721
    Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.
    Type: Application
    Filed: November 11, 2021
    Publication date: May 19, 2022
    Inventors: John J.M. WIENER, Cheryl A. GRICE, Daniel J. BUZARD, Justin S. CISAR, Olivia Delene WEBER, Amy ALLAN, Nicholas RAFFAELE, Jeanne MOODY, Michael B. SHAGHAFI
  • DUAL MAGL AND FAAH INHIBITORS
    Publication number: 20210386734
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Application
    Filed: August 25, 2021
    Publication date: December 16, 2021
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J.M. Wiener, Olivia D. Weber
  • Pyrazole MAGL inhibitors
    Patent number: 11149037
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 19, 2021
    Assignee: H. LUNDBECK A/S
    Inventors: Cheryl A. Grice, Olivia D. Weber, Daniel J. Buzard, Michael B. Shaghafi, John J. M. Wiener, Justin S. Cisar, Katharine K. Duncan
  • Dual MAGL and FAAH inhibitors
    Patent number: 11129827
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: September 28, 2021
    Assignee: Abide Therapeutics, Inc.
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J. M. Wiener, Olivia D. Weber
  • CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20210188793
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Application
    Filed: March 8, 2021
    Publication date: June 24, 2021
    Inventors: Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Micah J. NIPHAKIS, Jae Won CHANG, Kenneth M. LUM, Benjamin F. CRAVATT
  • Carbamate compounds and methods of making and using same
    Patent number: 11021453
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for a method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: June 1, 2021
    Assignees: LUNDBECK LA JOLLA RESEARCH CENTER, INC., THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Micah J. Niphakis, Jae Won Chang, Kenneth M. Lum, Benjamin F. Cravatt
  • Spirocycle compounds and methods of making and using same
    Patent number: 10781211
    Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 22, 2020
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Daniel J. Buzard, Michael B. Shaghafi, Justin S. Cisar, Cheryl A. Grice, Todd K. Jones, Olivia D. Weber
  • CARBAMATE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20200270223
    Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
    Type: Application
    Filed: December 17, 2019
    Publication date: August 27, 2020
    Inventors: Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Micah J. NIPHAKIS, Jae Won CHANG, Kenneth M. LUM, Benjamin F. CRAVATT
  • PYRAZOLE MAGL INHIBITORS
    Publication number: 20200087304
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 22, 2018
    Publication date: March 19, 2020
    Inventors: Cheryl A. GRICE, Olivia D. WEBER, Daniel J. BUZARD, Michael B. SHAGHAFI, John J.M. WIENER, Justin S. CISAR, Katharine K. DUNCAN
  • SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME
    Publication number: 20200022977
    Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
    Type: Application
    Filed: May 11, 2017
    Publication date: January 23, 2020
    Applicant: Abide Therapeutics, Inc.
    Inventors: Daniel J. BUZARD, Michael B. SHAGHAFI, Justin S. CISAR, Cheryl A. GRICE, Todd K. JONES, Olivia D. WEBER
  • Radiolabeled monoacylglycerol lipase occupancy probe
    Patent number: 10463753
    Abstract: Provided herein are monoacylglycerol lipase (MGLL) occupancy probes comprising a MGLL inhibitor containing a positron emission tomography (PET) tracer radionuclide. Also provided are methods of assessing MGLL enzyme occupancy of a MGLL inhibitor using the radiolabeled occupancy probes described herein.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: November 5, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Justin S. Cisar, Iain Peter Fraser
  • DUAL MAGL AND FAAH INHIBITORS
    Publication number: 20190282568
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Application
    Filed: June 4, 2019
    Publication date: September 19, 2019
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J.M. Wiener, Olivia D. Weber
  • Pyrazole compounds and methods of making and using same
    Patent number: 10385057
    Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: August 20, 2019
    Assignee: LUNDBECK LA JOLLA RESEARCH CENTER, INC.
    Inventors: Cheryl A. Grice, Todd K. Jones, Katharine K. Duncan, Olivia D. Weber, Justin S. Cisar, Jeffrey E. Merit
  • Dual MAGL and FAAH inhibitors
    Patent number: 10350205
    Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: July 16, 2019
    Assignee: Abide Therapeutics, Inc.
    Inventors: Cheryl A. Grice, Justin S. Cisar, Katharine K. Duncan, Yu Feng, John J. M. Wiener, Olivia D. Weber