Patents by Inventor Justin T. Stege
Justin T. Stege has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9234216Abstract: In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units ?-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (?-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g.Type: GrantFiled: October 6, 2011Date of Patent: January 12, 2016Assignee: BP Corporation North America Inc.Inventors: Justin T. Stege, Alexander Varvak, John Poland, Chris S. Lyon, Shaun Healey, Peter Luginbuhl
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Publication number: 20150329880Abstract: The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.Type: ApplicationFiled: August 3, 2015Publication date: November 19, 2015Inventors: Justin T. Stege, Alexander Varvak, John Poland, Chris S. Lyon, Shaun Healey, Peter Luginbuhl
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Patent number: 9096871Abstract: The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.Type: GrantFiled: October 6, 2011Date of Patent: August 4, 2015Assignee: BP Corporation North America Inc.Inventors: Justin T. Stege, Alexander Varvak, John Poland, Chris S. Lyon, Shaun Healey, Peter Luginbuhl
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Publication number: 20150010961Abstract: The present invention relates to a family 5 glycoside hydrolase variant having endoglucanase activity, polynucleotides encoding the family 5 glycoside hydrolase variant, vectors, host cells comprising the polynucleotides, and methods for using the family 5 glycoside hydrolase variant.Type: ApplicationFiled: September 25, 2014Publication date: January 8, 2015Inventors: John Poland, Justin T. Stege
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Publication number: 20140287471Abstract: The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.Type: ApplicationFiled: October 5, 2012Publication date: September 25, 2014Applicant: Bp Corporation North America Inc.Inventors: Sarah Richardson Hanson, Justin T. Stege, Cecilia Cheng, Peter Luginbuhl
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Publication number: 20140223602Abstract: The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ?-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention.Type: ApplicationFiled: September 27, 2013Publication date: August 7, 2014Applicant: BP Corporation North America LLCInventors: Cathy Chang, Justin T. Stege, Nahla M. Aboushadi, Gordana Djordjevic, Ellen G. Burke, Peter Luginbuhl, Mark Dycaico, Toby H. Richardson, John Poland, Hefner Ying, Stacy M. Miles
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Publication number: 20140147894Abstract: The present disclosure relates to variant CBH I polypeptides that have reduced product inhibition, and compositions, e.g., cellulase compositions, comprising variant CBH I polypeptides. The variant CBH I polypeptides and related compositions can be used in variety of agricultural and industrial applications. The present disclosure further relates to nucleic acids encoding variant CBH I polypeptides and host cells that recombinantly express the variant CBH I polypeptides.Type: ApplicationFiled: October 6, 2011Publication date: May 29, 2014Applicant: BP Corporation North America Inc.Inventors: Justin T. Stege, Alexander Varvak, John Poland, Chris S. Lyon, Shaun Healey, Peter Luginhuhl
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Publication number: 20140004571Abstract: The present disclosure relates methods and compositions for pretreatment of biomass, for example to form a biomass slurry suitable for downstream processing (e.g., saccharification, fermentation, etc.). The present methods provide several advantages in industrial operations, such as better heat exchange, reduced power and water usage, and the ability to carry out reactions continuously due to the reduced requirement for cleaning reaction vessels.Type: ApplicationFiled: December 3, 2012Publication date: January 2, 2014Applicant: BP Corporation North America Inc.Inventors: James B. Garrett, Justin T. Stege, William M. Lafferty, Arne I. Solbak, JR., Sarah Richardson Hanson, John Poland
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Publication number: 20130244292Abstract: The present invention relates to a family 5 glycoside hydrolase variant having endoglucanase activity, polynucleotides encoding the family 5 glycoside hydrolase variant, vectors, host cells comprising the polynucleotides, and methods for using the family 5 glycoside hydrolase variant.Type: ApplicationFiled: March 15, 2013Publication date: September 19, 2013Applicant: BP Corporation North America Inc.Inventors: John Poland, Justin T. Stege
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Publication number: 20130203128Abstract: In alternative embodiments, the invention provides polypeptides having a lignocellulolytic (lignocellulosic) activity, e.g., a ligninolytic and cellulolytic activity, including, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase (cbhl) (e.g., an exo-cellobiohydrolase, e.g., having an “exo” activity that can processively release cellobiose units ?-1,4 glucose-glucose disaccharide), a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a (?-xylosidase) and/or an arabinofuranosidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides and nucleic acids of the invention are used in a variety of pharmaceutical, agricultural and industrial contexts; for example, as enzymes for the bioconversion of a biomass, e.g.Type: ApplicationFiled: October 6, 2011Publication date: August 8, 2013Applicant: BP Corporation North America Inc,Inventors: Justin T. Stege, Alexander Varvak, John Poland, Chris S. Lyon, Shaun Healey, Peter Luginbuhl
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Patent number: 7781645Abstract: The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.Type: GrantFiled: May 27, 2008Date of Patent: August 24, 2010Assignees: Syngenta Participations AG, The Scripps Research InstituteInventors: Carlos F. Barbas, III, Justin T. Stege, Xueni Guan, Bipin Dalmia
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Publication number: 20100189706Abstract: The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta-glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a ?-xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention.Type: ApplicationFiled: January 30, 2008Publication date: July 29, 2010Inventors: Cathy Chang, Justin T. Stege, Nahla Aboushadi, Gordana Djordjevic, Ellen Burke, Peter Luginbuhl, Mark Dycaico, Toby Richardson, John Poland, Ying Hefner, Stacy Marie Miles
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Patent number: 7642079Abstract: The invention is directed to polypeptides having protease activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. The polypeptides of the invention can be used in a variety of diagnostic, therapeutic, and industrial contexts. The polypeptides of the invention can be used as, e.g., an additive for a detergent, for processing foods and for chemical synthesis utilizing a reverse reaction.Type: GrantFiled: October 10, 2003Date of Patent: January 5, 2010Inventors: Michelle Cayouette, Connie Jo Hansen, Amy McClure, May Sun, Svetlana Gramatikova, Mark Dycaico, Nelson R. Barton, Justin T. Stege, Nahla M. Aboushadi
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Publication number: 20090007300Abstract: The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.Type: ApplicationFiled: May 27, 2008Publication date: January 1, 2009Inventors: Carlos F. BARBAS, III, Justin T. Stege, Xueni Guan, Bipin Dalmia
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Patent number: 7378510Abstract: The invention relates to nucleic acids encoding synthetic zinc finger proteins for gene regulation in plants. The invention also relates to methods of producing synthetic zinc finger protein in host cells.Type: GrantFiled: December 14, 2006Date of Patent: May 27, 2008Assignees: The Scripps Research Institute, Syngenta Participations AGInventors: Carlos F. Barbas, III, Justin T. Stege, Xueni Guan, Bipin Dalmia
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Patent number: 7151201Abstract: The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.Type: GrantFiled: January 19, 2001Date of Patent: December 19, 2006Assignees: The Scripps Research Institute, Syngenta Participations AGInventors: Carlos F. Barbas, III, Justin T. Stege, Xueni Guan, Bipin Dalmia
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Publication number: 20030037355Abstract: The invention relates to the field of plant and agricultural technology. More specifically, the invention relates to the use of zinc finger proteins and fusions of said proteins to regulate gene expression and metabolic pathways in plants.Type: ApplicationFiled: January 19, 2001Publication date: February 20, 2003Inventors: Carlos F. Barbas, Justin T. Stege, Xueni Guan, Bipin Dalmia