Patents by Inventor Justina SILEIKYTE

Justina SILEIKYTE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)
    Publication number: 20240067600
    Abstract: The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Application
    Filed: March 16, 2023
    Publication date: February 29, 2024
    Applicants: UNIVERSITY OF KANSAS, Oregon Health & Science University
    Inventors: Sudeshna ROY, Paolo BERNARDI, Michael FORTE, Frank SCHOENEN, Justina SILEIKYTE
  • SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)
    Publication number: 20220396547
    Abstract: The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Application
    Filed: December 14, 2020
    Publication date: December 15, 2022
    Inventors: Sudeshna ROY, Paolo BERNARDI, Michael FORTE, Frank SCHOENEN, Justina SILEIKYTE
  • SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY
    Publication number: 20220289690
    Abstract: The present invention provides compounds useful as mitochondrial permeability transition pore (mtPTP) inhibitors, the compounds being of Formula (I), or a pharmaceutically acceptable salt thereof wherein R1 is selected from the group of H, halogen, and C1-C3 alkyl; and R2 is selected from the group of H, CF3, and halogen; with the proviso that at least one of R1 and R2 is halogen or CF3.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 15, 2022
    Applicant: Oregon Health & Science University
    Inventors: Michael Cohen, Michael Forte, Justina Sileikyte, Aaron Nilsen, Jordan Devereaux, Paolo Bernardi
  • Small molecule inhibitors of the mitochondrial permeability transition pore (mtPTP)
    Patent number: 10865181
    Abstract: The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Grant
    Filed: November 4, 2015
    Date of Patent: December 15, 2020
    Assignees: UNIVERSITY OF KANSAS, Oregon Health & Science University
    Inventors: Sudeshna Roy, Paolo Bernardi, Michael Forte, Frank Schoenen, Justina Sileikyte
  • SMALL MOLECULE INHIBITORS OF THE MITOCHONDRIAL PERMEABILITY TRANSITION PORE (mtPTP)
    Publication number: 20180282264
    Abstract: The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.
    Type: Application
    Filed: November 4, 2015
    Publication date: October 4, 2018
    Inventors: Sudeshna ROY, Paolo BERNARDI, Michael FORTE, Frank SCHOENEN, Justina SILEIKYTE