Patents by Inventor Jutta Heim

Jutta Heim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pectin lyase genes of aspergillus niger
    Patent number: 5447862
    Abstract: Recombinant DNA molecules coding for pectin lyase (PL) expression systems and derivatives thereof, such as the structural genes of PLA, PLB, PLC, PLD, PLE and PLF, and corresponding regulatory sequences, e.g. promoter, signal and terminator sequences, and hybrid vectors comprising corresponding DNAs, including hybrid vectors with DNA coding for homologous or heterologous polypeptides, hosts, especially filamentous fungi, e.g. Aspergillus hosts, transformed by said vectors, methods for the preparation of said recombinant DNA molecules and said hosts and the use of the recombinant DNA molecules for the preparation of new expression systems. A further objective is the preparation of polypeptides by means of said DNAs and said hosts.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: September 5, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Jutta Heim, Bernd Meyhack, Christof Gysler, Jacob Visser, Hermanus C. M. Kester
  • Pharmaceutical compositions comprising modified and unmodified plasminogen activators
    Patent number: 5409700
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of two different plasminogen activators which are used for the prophylaxis and therapie of thrombosis.
    Type: Grant
    Filed: April 7, 1993
    Date of Patent: April 25, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Jutta Heim, Fredericus A. M. Asselbergs, Rolf Burgi
  • DNA molecules encoding hybrid proteins of tissue plasminogen activator and urokinase
    Patent number: 5242819
    Abstract: Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one of the N-glycosylation sites is modified such that glycosylation cannot take place at these sites exhibit valuable pharmacological properties. The hybrid plasminogen activators are produced by recombinant DNA technology.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: September 7, 1993
    Assignee: Ciba-Geigy Corporation
    Inventors: Bhanu Rajput, Bhabatosh Chaudhuri, Fredericus A. M. Asselbergs, Bernd Meyhack, Jutta Heim, Jan van Oostrum, Sefik Alkan
  • Process for the production of urokinase using Saccharomyes cerevisiae
    Patent number: 5175105
    Abstract: Novel human plasminogen activators of the urokinase type are produced by yeast cells transformed with a hybrid vector comprising a DNA sequence coding for said human plasminogen activator. Novel hybrid vectors, yeast hosts transformed with such hybrid vectors and processes for the production thereof are also provided.
    Type: Grant
    Filed: April 8, 1988
    Date of Patent: December 29, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Bernd Meyhack, Jutta Heim, Rolf Burgi
  • Pharmaceutically active combination
    Patent number: 5126134
    Abstract: There is provided a pharmaceutical composition comprising as component A a plasminogen activator and as component B hirudin together with a pharmaceutically acceptable carrier. The pharmaceutical composition can be used for the prophylaxis and therapy of thrombosis or diseases caused by thrombosis.
    Type: Grant
    Filed: September 18, 1989
    Date of Patent: June 30, 1992
    Assignees: Ciba-Geigy Corporation, UCP Gen-Pharma AG
    Inventors: Jutta Heim, Giancarlo Agnelli, Czeslaw Czendlik