Patents by Inventor Jye Yng Teo
Jye Yng Teo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220265702Abstract: Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.Type: ApplicationFiled: April 14, 2022Publication date: August 25, 2022Inventors: James L. Hedrick, Yi Yan Yang, Nathaniel H. Park, Jiayu Leong, Chuan Yang, Xin Ding, Yiran Zhen, Cherylette Anne Alexander, Jye Yng Teo
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Patent number: 11331341Abstract: Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.Type: GrantFiled: March 27, 2020Date of Patent: May 17, 2022Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: James L. Hedrick, Yi Yan Yang, Nathaniel H. Park, Jiayu Leong, Chuan Yang, Xin Ding, Yiran Zhen, Cherylette Anne Alexander, Jye Yng Teo
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Publication number: 20210299160Abstract: Techniques regarding a chemical composition that can be utilized within one or more combination therapies to treat a microbial infection are provided. For example, one or more embodiments described herein can comprise a chemical composition that includes a first triblock polymer comprising a quaternary ammonium functionalized polycarbonate block and exhibiting anticancer activity via a lytic mechanism. The chemical composition can also include a second triblock polymer comprising a guanidinium functionalized polycarbonate block and exhibiting anticancer activity via a translocation mechanism.Type: ApplicationFiled: March 27, 2020Publication date: September 30, 2021Inventors: James L. Hedrick, Yi Yan Yang, Nathaniel H. Park, Jiayu Leong, Chuan Yang, Xin Ding, Yiran Zhen, Cherylette Anne Alexander, Jye Yng Teo
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Patent number: 9901649Abstract: Amphiphilic block copolymers (BCPs) were prepared comprising a poly(ethylene oxide) block and a biodegradable polycarbonate block functionalized with disulfide groups and carboxylic acid groups. The BCPs form self-assembled micellar particles in aqueous solution that can be loaded with hydrophobic drugs for therapeutic drug delivery. The loaded particles have small particle sizes (<100 nm), narrow particle size distributions, and high drug loading capacity (up to about 50 wt %) based on total dry weight of the loaded particles. Particles loaded with DOX released the DOX in response to changes in pH and glutathione (GSH) redox chemistry. The loaded particles efficiently delivered and released DOX within tumor cells, effectively suppressing growth of the tumor cells at a similar or even lower drug concentration than free DOX. Blank particles containing no DOX did not induce cytotoxicity to cells.Type: GrantFiled: May 3, 2016Date of Patent: February 27, 2018Assignees: International Business Machines Corporation, Agency For Science, Technology and ResearchInventors: Willy Chin, Yukti Choudhury, Shujun Gao, James L. Hedrick, Xiyu Ke, Min-Han Tan, Jye Yng Teo, Yi Yan Yang
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Publication number: 20170319704Abstract: Amphiphilic block copolymers (BCPs) were prepared comprising a poly(ethylene oxide) block and a biodegradable polycarbonate block functionalized with disulfide groups and carboxylic acid groups. The BCPs form self-assembled micellar particles in aqueous solution that can be loaded with hydrophobic drugs for therapeutic drug delivery. The loaded particles have small particle sizes (<100 nm), narrow particle size distributions, and high drug loading capacity (up to about 50 wt %) based on total dry weight of the loaded particles. Particles loaded with DOX released the DOX in response to changes in pH and glutathione (GSH) redox chemistry. The loaded particles efficiently delivered and released DOX within tumor cells, effectively suppressing growth of the tumor cells at a similar or even lower drug concentration than free DOX. Blank particles containing no DOX did not induce cytotoxicity to cells.Type: ApplicationFiled: May 3, 2016Publication date: November 9, 2017Inventors: Willy Chin, Yukti Choudhury, Shujun Gao, James L. Hedrick, Xiyu Ke, Min-Han Tan, Jye Yng Teo, Yi Yan Yang
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Patent number: 9642360Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: GrantFiled: June 25, 2015Date of Patent: May 9, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20170094964Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: ApplicationFiled: December 19, 2016Publication date: April 6, 2017Inventors: Julian M. W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Patent number: 9580554Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: GrantFiled: May 6, 2015Date of Patent: February 28, 2017Assignees: International Business Machines Corporation, Agency For Science, Technology And ResearchInventors: Gregory Breyta, Julian M. W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Shaoqiong Liu, Alshakim Nelson, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20160374335Abstract: Cationic antimicrobial polymers have been synthesized by a bulk addition polymerization of a nucleophilic agent comprising two tertiary amines and an electrophilic agent that comprises two leaving groups and an aromatic ring between the leaving groups. The reaction solvent for the polymerization is chosen to allow precipitation of the cationic polymer at the polymerization temperature, thereby limiting molecular weight. Quaternization and polymerization occur concurrently. The cationic polymers can be highly active against Gram-negative and Gram-positive microbes, and/or fungi. The cationic polymers can also be non-hemolytic and non-cytotoxic at the effective concentration against the microbes.Type: ApplicationFiled: June 25, 2015Publication date: December 29, 2016Inventors: Julian M.W. Chan, James L. Hedrick, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang
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Publication number: 20160326319Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.Type: ApplicationFiled: May 6, 2015Publication date: November 10, 2016Inventors: Gregory Breyta, Julian M.W. Chan, Daniel J. Coady, Amanda C. Engler, Jeannette M. Garcia, Wei Han, James L. Hedrick, Shaoqiong Liu, Alshakim Nelson, Robert J. Ono, Jye Yng Teo, Yi Yan Yang, Mu San Zhang