Patents by Inventor Jyh-Haur Chern
Jyh-Haur Chern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8415482Abstract: Compounds useful for treating hepatitis C virus infection. The compounds are of formula (I): wherein A, B, C, D, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, m, n, p, q, r, t, u, and v are defined herein. Also disclosed is a method for treating hepatitis C virus infection with these compounds.Type: GrantFiled: December 2, 2010Date of Patent: April 9, 2013Assignee: National Health Research InstitutesInventors: Jyh-Haur Chern, Yu-Sheng Chao
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Patent number: 8198284Abstract: A method for treating a neurodegenerative disorder. The method includes administering to a subject in need thereof an effective amount of one or more thiourea compounds of formula (I) or (II): Each variable in formula (I) or (II) is defined herein. Also disclosed is use of these thiourea compounds to reduce microglia-mediated neuro-inflammation or enhancing microglial phagocytosis of A?.Type: GrantFiled: March 24, 2009Date of Patent: June 12, 2012Assignee: National Health Research InstitutesInventors: Feng-Shiun Shie, Jyh-Haur Chern, Yu-Sheng Chao
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Patent number: 7985763Abstract: A compound of the following formula: in which R1, R2, R3, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating Hepatitis C virus infection using such a compound.Type: GrantFiled: March 26, 2008Date of Patent: July 26, 2011Assignee: National Health Research InstitutesInventors: Li-Wen Wang, Tsu-An Hsu, Yen-Chun Lee, Iou-Jiun Kang, Chung-Chi Lee, Yu-Sheng Chao, Jyh-Haur Chern
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Publication number: 20110136799Abstract: Compounds of formula (I): wherein A, B, C, D, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, m, n, p, q, r, t, u, and v are defined herein. Also disclosed is a method for treating hepatitis C virus infection with these compounds.Type: ApplicationFiled: December 2, 2010Publication date: June 9, 2011Applicant: National Health Research InstitutesInventors: Jyh-Haur Chern, Yu-Sheng Chao
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Patent number: 7939523Abstract: Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.Type: GrantFiled: January 5, 2009Date of Patent: May 10, 2011Assignee: National Health Research InstitutesInventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yen-Shian Wu, Sheng-Ju Hsu, Yueh Andrew Yueh, Yu-Sheng Chao
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Patent number: 7897764Abstract: Thiourea compounds of the following formula: wherein n, R1, R2, R3, A1, A2, X, Y, and Z are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.Type: GrantFiled: May 5, 2008Date of Patent: March 1, 2011Assignee: National Health Research InstitutesInventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao
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Publication number: 20090275596Abstract: A method for treating a neurodegenerative disorder. The method includes administering to a subject in need thereof an effective amount of one or more thiourea compounds of formula (I) or (II): Each variable in formula (I) or (II) is defined herein. Also disclosed is use of these thiourea compounds to reduce microglia-mediated neuro-inflammation or enhancing microglial phagocytosis of A?.Type: ApplicationFiled: March 24, 2009Publication date: November 5, 2009Applicant: National Health Research InstitutesInventors: Feng-Shiun Shie, Jyh-Haur Chern, Yu-Sheng Chao
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Publication number: 20090176766Abstract: Imidazolidinone and imidazolinethione compounds of formula (I): wherein R1, R2, R3, A1, A2, X, Y, Z, m, n, p, x, and y are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.Type: ApplicationFiled: January 5, 2009Publication date: July 9, 2009Applicant: National Health Research InstitutesInventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yen-Shian Wu, Sheng-Ju Hsu, Yueh Andrew Yueh, Yu-Sheng Chao
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Patent number: 7501445Abstract: This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.Type: GrantFiled: October 30, 2006Date of Patent: March 10, 2009Assignee: National Health Research InstitutesInventors: Jyh-Haur Chern, Shin-Ru Shih, Chiung-Tong Chen, Chih-Shiang Chang, Chung-Chi Lee, Yen-Chun Lee, Chia-Liang Tai
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Publication number: 20080306090Abstract: Thiourea compounds of the following formula: wherein n, R1, R2, R3, A1, A2, X, Y, and Z are defined herein. Also disclosed is a method of treating hepatitis C virus infection with these compounds.Type: ApplicationFiled: May 5, 2008Publication date: December 11, 2008Applicant: National Health Research InstitutesInventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao
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Publication number: 20080255189Abstract: A compound of the following formula: in which R1, R2, R3, U, V, T, W, X, Y, Z, m, n, p, x, y, and z are as defined herein. Also disclosed are (1) a pharmaceutical composition containing such a compound, and (2) a method for treating Hepatitis C virus infection using such a compound.Type: ApplicationFiled: March 26, 2008Publication date: October 16, 2008Applicant: National Health Research InstitutesInventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao
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Publication number: 20080113975Abstract: This invention relates to thiourea compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.Type: ApplicationFiled: August 15, 2007Publication date: May 15, 2008Applicant: National Health Research InstitutesInventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao
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Publication number: 20080096875Abstract: This invention relates to thiourea compounds of formula (II) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat hepatitis C virus infection.Type: ApplicationFiled: August 15, 2007Publication date: April 24, 2008Applicant: National Health Research InstitutesInventors: Jyh-Haur Chern, Tsu-An Hsu, Iou-Jiun Kang, Li-Wen Wang, Chung-Chi Lee, Yen-Chun Lee, Yu-Sheng Chao
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Patent number: 7259174Abstract: Compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein. Also disclosed are pharmaceutical compositions each containing one or more of these compounds, and use thereof in treating enteroviral infection.Type: GrantFiled: May 23, 2005Date of Patent: August 21, 2007Assignee: National Health Research InstitutesInventors: Jyh-Haur Chern, Shin-Ru Shih, Chih-Shiang Chang, Chung-Chi Lee, Yen-Chun Lee
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Publication number: 20070049623Abstract: This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.Type: ApplicationFiled: October 30, 2006Publication date: March 1, 2007Inventors: Jyh-Haur Chern, Shin-Ru Shih, Chiung-Tong Chen, Chih-Shiang Chang, Chung-Chi Lee, Yen-Chun Lee, Chia-Liang Tai
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Patent number: 7129359Abstract: This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of the compounds in treating enterovirus infection.Type: GrantFiled: November 19, 2003Date of Patent: October 31, 2006Assignee: National Health Research InstitutesInventors: Jyh-Haur Chern, Shin-Ru Shih, Chiung-Tong Chen, Chih-Shiang Chang, Chung-Chi Lee, Yen-Chun Lee, Chia-Liang Tai
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Publication number: 20050267164Abstract: Compounds of the following formula: in which R1, R2, Al, A2, X, Y, m, n, p, x and y are as defined herein. Also disclosed are pharmaceutical compositions each containing one or more of these compounds, and use thereof in treating enteroviral infection.Type: ApplicationFiled: May 23, 2005Publication date: December 1, 2005Inventors: Jyh-Haur Chern, Shin-Ru Shih, Chih-Shiang Chang, Chung-Chi Lee, Yen-Chun Lee
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Patent number: 6815444Abstract: This invention features, among others, a pyrazolopyrimidine compound of formula (A): A is (CH2)q—CHRaRb; each of R1 and R2, independently, is hydrogen, halogen, cyano, nitro, or alkyl; or R1 and R2 taken together is (CH2)r; each of R3 and R4, independently, is hydrogen, halogen, cyano, nitro, or alkyl; each of R5, Ra, and Rb, independently, is aryl, aralkyl, or heteroaryl, optionally substituted with halogen, cyano, nitro, alkyl, aryl, aralkyl, heteroaryl, OR, O(O)CR, C(O)R, C(O)OR, C(O)NRR′, SR, S(O)R, S(O)OR, NRR′, NR(O)CR′, NRC(O)OR′, or NRC(O)NR′R″; each of m, n, o, p, and r, independently, is 0 or 1, and q is 0, 1, or 2; in which each of R, R′, and R″, independently, is hydrogen or alkyl, provided that the sum of m, n, o, and p is 1, 2, 3, or 4.Type: GrantFiled: May 23, 2003Date of Patent: November 9, 2004Assignee: National Health Research InstitutesInventors: Jyh-Haur Chern, Kak-Shan Shia, Shin-Ru Shih, Tsu-An Hsu, Chia-Liang Tai
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Publication number: 20040204400Abstract: This invention features, among others, a pyrazolopyrimidine compound of formula (A): 1Type: ApplicationFiled: May 23, 2003Publication date: October 14, 2004Inventors: Jyh-Haur Chern, Kak-Shan Shia, Shin-Ru Shih, Tsu-An Hsu, Chia-Liang Tai
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Publication number: 20040116476Abstract: This invention relates to compounds of the following formula: 1Type: ApplicationFiled: November 19, 2003Publication date: June 17, 2004Inventors: Jyh-Haur Chern, Shin-Ru Shih, Chiung-Tong Chen, Chih-Shiang Chang, Chung-Chi Lee, Yen-Chun Lee, Chia-Liang Tai