Patents by Inventor Jyh-hsiung Liao

Jyh-hsiung Liao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing ixazomib citrate and intermediates therefor
    Patent number: 10118937
    Abstract: A process for making ixazomib citrate of formula VI comprising reacting a compound of formula V with citric acid to form ixazomib citrate of formula VI: wherein R is hydrogen or an amide protecting group.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: November 6, 2018
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Tsung-Yu Hsiao, Jyh-Hsiung Liao
  • Process for preparing SGLT2 inhibitors and intermediates thereof
    Patent number: 9834533
    Abstract: The present invention provides processes for preparing SGLT2 inhibitors, such as dapagliflozin and empagliflozin.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: December 5, 2017
    Assignee: ScinoPharm Taiwan, Ltd.
    Inventors: Tsung-Yu Hsiao, Jyh-Hsiung Liao
  • PROCESS FOR PREPARING SGLT2 INHIBITORS AND INTERMEDIATES THEREOF
    Publication number: 20170240520
    Abstract: The present invention provides processes for preparing SGLT2 inhibitors, such as dapagliflozin and empagliflozin.
    Type: Application
    Filed: February 10, 2017
    Publication date: August 24, 2017
    Applicant: ScinoPharm Taiwan, Ltd.
    Inventors: Tsung-Yu Hsiao, Jyh-Hsiung Liao
  • Process for the preparation of ?--arylglucosides
    Patent number: 9328100
    Abstract: The present application discloses a stereoselective process for the preparation of ?-C-arylglucosides that does not require the use of conventional carbohydrate protecting groups. In one embodiment, the stereoselective process comprises the preparation of the compound of formula I: the process comprising: a) contacting 1,6-anhydro-?-D-glucopyranose with a compound of formula II, R1R2R3Al, in a solvent to form a first reaction mixture; b) contacting the first reaction mixture of step a) with a second reaction mixture to form a third reaction mixture, wherein the second reaction mixture is prepared by contacting an organoaluminum compound of formula III, R4aR5bAlXc, with a compound of formula IV, ArM; and c) contacting the third reaction mixture with a reagent to form the compound of the formula I.
    Type: Grant
    Filed: April 10, 2015
    Date of Patent: May 3, 2016
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Julian Paul Henschke, Ping-Yu Wu, Jyh-Hsiung Liao, Chen-Wei Lin
  • PROCESS FOR THE PREPARATION OF beta-C-ARYLGLUCOSIDES
    Publication number: 20150291569
    Abstract: The present application discloses a stereoselective process for the preparation of ?-C-arylglucosides that does not require the use of conventional carbohydrate protecting groups.
    Type: Application
    Filed: April 10, 2015
    Publication date: October 15, 2015
    Applicant: ScinoPharm Taiwan, Ltd.
    Inventors: Julian Paul Henschke, Ping-Yu Wu, Jyh-Hsiung Liao, Chen-Wei Lin
  • Process for the preparation of ?-C-aryl glucosides
    Patent number: 8952139
    Abstract: The present invention provides processes (e.g., arylation reaction) for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: February 10, 2015
    Assignee: ScinoPharm Taiwan, Ltd
    Inventors: Julian Paul Henschke, Chen-Wei Lin, Ping-Yu Wu, Chi-Nung Hsiao, Jyh-Hsiung Liao, Tsung-Yu Hsiao
  • Process for the Preparation of ß-C-Aryl Glucosides
    Publication number: 20140128595
    Abstract: The present invention provides processes for stereoselectively preparing C-arylglucosides that can be useful as synthetic building block or drugs, including SGLT2 inhibitors.
    Type: Application
    Filed: November 7, 2012
    Publication date: May 8, 2014
    Applicant: ScinoPharm Taiwan, LTD.
    Inventors: Julian Paul Henschke, Chen-Wei Lin, Ping-Yu Wu, Chi-Nung Hsiao, Jyh-Hsiung Liao, Tsung-Yu Hsiao
  • Thiophene compounds
    Patent number: 7834046
    Abstract: This invention relates to thiophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: November 16, 2010
    Assignee: National Health Research Institutes
    Inventors: Kak-shan Shia, Chia-Liang Tai, Jyh-hsiung Liao, Ming-shiu Hung, Yu-Sheng Chao
  • Thiophene Compounds
    Publication number: 20090029969
    Abstract: This invention relates to thiophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Application
    Filed: October 2, 2007
    Publication date: January 29, 2009
    Applicant: National Health Research Institutes
    Inventors: Kak-shan Shia, Chia-Liang Tai, Jyh-hsiung Liao, Ming-shiu Hung, Yu-Sheng Chao
  • THIOPHENE COMPOUNDS
    Publication number: 20080090810
    Abstract: This invention relates to thiophene compounds of formula (I) shown below: Each variable in formula (I) is defined in the specification. These compounds can be used to treat cannabinoid-receptor mediated disorders.
    Type: Application
    Filed: October 2, 2007
    Publication date: April 17, 2008
    Applicant: National Health Research Institutes
    Inventors: Kak-Shan Shia, Chia-Liang Tai, Jyh-hsiung Liao, Ming-Shiu Hung, Yu-Sheng Chao