Patents by Inventor Jyh-Perng WANG
Jyh-Perng WANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11253581Abstract: The present disclosure relates to a composition for preventing and treating Mycoplasma synoviae infection, the composition comprising Tuf, NOX, MS53-0285 or a combination thereof as active ingredients. The composition of the present disclosure is effective in alleviating symptoms caused by Mycoplasma synoviae infection and can be used as an effective tool in preventing or treating poultry diseases.Type: GrantFiled: November 1, 2017Date of Patent: February 22, 2022Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Ho-Yuan Chou, Jyh-Perng Wang, Zeng-Weng Chen, Weng-Zeng Huang, Hsiu-Hui Wu, Hui-Jie Lin, Sheng-Xiang Huang
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Publication number: 20220002353Abstract: The application relates to a dextran affinity tag and use thereof. The present application provides an affinity tag, which is a segment of dextran binding domain, and can purify a target protein by its affinity with the dextran. The affinity tag of the present application has the advantages of more efficient in preparation and purification, and can be widely used in industrial applications that require protein purification processes.Type: ApplicationFiled: October 29, 2018Publication date: January 6, 2022Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng LIN, Jyh-Perng WANG, Zeng-Weng CHEN, Wen-Zheng HUANG, You-Lin ZHUO, Shih-Ling HSUAN
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Publication number: 20210322530Abstract: The present disclosure relates to a composition for preventing and treating Mycoplasma synoviae infection, the composition comprising Tuf, NOX, MS53-0285 or a combination thereof as active ingredients. The composition of the present disclosure is effective in alleviating symptoms caused by Mycoplasma synoviae infection and can be used as an effective tool in preventing or treating poultry diseases.Type: ApplicationFiled: November 1, 2017Publication date: October 21, 2021Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng LIN, Ho-Yuan CHOU, Jyh-Perng WANG, Zeng-Weng CHEN, Weng-Zeng HUANG, Hsiu-Hui WU, Hui-Jie LIN, Sheng-Xiang HUANG
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Patent number: 10822602Abstract: The present invention provides a ?-agarase, a composition containing the same and applications thereof. The present ?-agarase provides the field a novel alternative and is favorable for the industrial utilities of the hydrolysis products of agarose. Furthermore, the present agarase is particularly modified for heterologous production by prokaryotic expression systems, and thereby is favorable for commercial use.Type: GrantFiled: March 20, 2017Date of Patent: November 3, 2020Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Zeng-Weng Chen, Hui-Jie Lin, Shu-Wei Chang, Weng-Zeng Huang, Jian-Fong Lai, Shih-Ling Hsuan
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Patent number: 10801031Abstract: A shuttle vector is provided which can be manipulated in various kinds of host cells, thereby providing a novel tool for the field of genetic engineering. Also provided are a prokaryotic host cell and a kit including said shuttle vector, so as to construct expression vectors which contain the target gene using the shuttle vector, thereby producing proteins in various host cells with one single vector.Type: GrantFiled: September 20, 2018Date of Patent: October 13, 2020Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Zeng-Weng Chen, Wen-Zheng Huang, Hung-Chih Wang, Shih-Ling Hsuan
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Patent number: 10767185Abstract: The present invention provides a preparation method for PCV2 capsid protein and a pharmaceutical composition containing said capsid protein. The method of the present invention uses a novel arabinose-induced expression vector and thereby improves the synthesis efficiency of said PCV2 capsid protein. On the other hand, the present pharmaceutical composition combines said capsid protein and other favorable components at a proper ratio so that achieves excellent immune-inducing effects.Type: GrantFiled: December 28, 2015Date of Patent: September 8, 2020Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Zeng-Weng Chen, Jyh-Perng Wang, Tzu-Ting Peng, Huei-Yu Lee, Weng-Zeng Huang, Shih-Rong Wang, Cheng-Yao Yang
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Patent number: 10758603Abstract: Disclosed is a composition for preventing and treating a Mycoplasma hyorhinis infection in swine. The composition uses XylF, DnaK, P72, or a combination thereof as an active pharmaceutical ingredient. Further disclosed are an expression vector and a method for producing the active pharmaceutical ingredient of the composition using a prokaryotic expression system.Type: GrantFiled: August 9, 2016Date of Patent: September 1, 2020Assignee: Agricultural Technology Research InstituteInventors: Jiunn-Horng Lin, Zeng-Weng Chen, Jyh-Perng Wang, Chiung-Wen Hsu, Weng-Zeng Huang, Ming-Wei Hsieh, Tzu-Ting Peng, Shih-Ling Hsuan
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Patent number: 10704051Abstract: The present invention provides an expression element and an expression cassette to establish a novel vector therefrom. The expression element of the present invention has an effect of enhancing the expression level of the target gene so that is highly industrial valuable. Accordingly, the present vector is taken as a novel tool for genetic engineering.Type: GrantFiled: December 29, 2014Date of Patent: July 7, 2020Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Zeng-Weng Chen, Chien-Yu Fang, Hao-Zhen Zeng, Jian-Fong Lai, Weng-Zeng Huang, Shih-Ling Hsuan
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Publication number: 20200023048Abstract: Disclosed is a composition for preventing and treating a Mycoplasma hyorhinis infection in swine. The composition uses XylF, DnaK, P72, or a combination thereof as an active pharmaceutical ingredient. Further disclosed are an expression vector and a method for producing the active pharmaceutical ingredient of the composition using a prokaryotic expression system.Type: ApplicationFiled: August 9, 2016Publication date: January 23, 2020Inventors: Jiunn-Horng LIN, Zeng-Weng CHEN, Jyh-Perng WANG, Chiung-Wen HSU, Weng-Zeng HUANG, Ming-Wei HSIEH, Tzu-Ting PENG, Shih-Ling HSUAN
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Publication number: 20190093113Abstract: The present application provides a shuttle vector which can be manipulated in various kinds of host cells, thereby providing a novel tool for the field of genetic engineering. On the other hand, the present application further provides a prokaryotic host cell and a kit comprising said shuttle vector, so as to construct expression vectors which contain the target gene using the shuttle vector, thereby producing proteins in various host cells with one single vector.Type: ApplicationFiled: September 20, 2018Publication date: March 28, 2019Applicant: Agricultural Technology Research InstituteInventors: Jiunn-Horng LIN, Jyh-Perng WANG, Zeng-Weng CHEN, Wen-Zheng HUANG, Hung-Chih WANG, Shih-Ling HSUAN
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Publication number: 20190078101Abstract: The present invention provides a preparation method for PCV2 capsid protein and a pharmaceutical composition containing said capsid protein. The method of the present invention uses a novel arabinose-induced expression vector and thereby improves the synthesis efficiency of said PCV2 capsid protein. On the other hand, the present pharmaceutical composition combines said capsid protein and other favorable components at a proper ratio so that achieves excellent immune-inducing effects.Type: ApplicationFiled: December 28, 2015Publication date: March 14, 2019Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng LIN, Zeng-Weng CHEN, Jyh-Perng WANG, Tzu-Ting PENG, Huei-Yu LEE, Weng-Zeng HUANG, Shih-Rong WANG, Cheng-Yao YANG
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Patent number: 10208093Abstract: The present invention provides a plasmid, method and kit for producing heat labile enterotoxin B-subunit based on a Bacillus subtilis expression system. By comparing with the conventional method in the art, the present invention has the advantages of high safety, good yield, and simplified process and is therefore favorable for the commercialization object of heat labile enterotoxin B-subunit in the application of vaccine adjuvant.Type: GrantFiled: December 16, 2013Date of Patent: February 19, 2019Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Chien-Yu Fang, Zeng-Weng Chen, Ming-Wei Hsieh, Hao-Zhen Zeng, Jian-Fong Lai, Weng-Zeng Huang, Tzu-Ting Peng
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Patent number: 10059749Abstract: The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention also provides a subunit vaccine made therefrom. Said proteins have been experimentally proved to have the capability of inducing sufficient immune response to avoid pigs from Mycoplasma spp. infection. Said vaccine may have one of said proteins as active ingredient; or may have two or more of said proteins and is formulated as a cocktail vaccine. The present vaccine not only is safer than the conventional vaccines but also has equal or even better immune efficiency than the conventional ones. Furthermore, fusion partners suitable for producing said proteins of high solubility are also proved, which can significantly reduce production cost.Type: GrantFiled: March 14, 2018Date of Patent: August 28, 2018Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Zeng-Weng Chen, Chien-Yu Fang, Ming-Wei Hsieh, Ping-Cheng Yang
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Publication number: 20180216119Abstract: The present invention provides an expression element and an expression cassette to establish a novel vector therefrom. The expression element of the present invention has an effect of enhancing the expression level of the target gene so that is highly industrial valuable. Accordingly, the present vector is taken as a novel tool for genetic engineering.Type: ApplicationFiled: December 29, 2014Publication date: August 2, 2018Applicant: Agricultural Technology Research InstituteInventors: Jiunn-Horng LIN, Jyh-Perng WANG, Zeng-Weng CHEN, Chien-Yu FANG, Hao-Zhen ZENG, Jian-Fong LAI, Weng-Zeng HUANG, Shih-Ling HSUAN
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Publication number: 20180208629Abstract: The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention also provides a subunit vaccine made therefrom. Said proteins have been experimentally proved to have the capability of inducing sufficient immune response to avoid pigs from Mycoplasma spp. infection. Said vaccine may have one of said proteins as active ingredient; or may have two or more of said proteins and is formulated as a cocktail vaccine. The present vaccine not only is safer than the conventional vaccines but also has equal or even better immune efficiency than the conventional ones. Furthermore, fusion partners suitable for producing said proteins of high solubility are also proved, which can significantly reduce production cost.Type: ApplicationFiled: March 14, 2018Publication date: July 26, 2018Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: JIUNN-HORNG LIN, JYH-PERNG WANG, ZENG-WENG CHEN, CHIEN-YU FANG, MING-WEI HSIEH, PING-CHENG YANG
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Patent number: 9951109Abstract: The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention also provides a subunit vaccine made therefrom. Said proteins have been experimentally proved to have the capability of inducing sufficient immune response to avoid pigs from Mycoplasma spp. infection. Said vaccine may have one of said proteins as active ingredient; or may have two or more of said proteins and is formulated as a cocktail vaccine. The present vaccine not only is safer than the conventional vaccines but also has equal or even better immune efficiency than the conventional ones. Furthermore, fusion partners suitable for producing said proteins of high solubility are also proved, which can significantly reduce production cost.Type: GrantFiled: November 21, 2013Date of Patent: April 24, 2018Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Zeng-Weng Chen, Chien-Yu Fang, Ming-Wei Hsieh, Ping-Cheng Yang
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Publication number: 20180044654Abstract: The present invention provides a ?-agarase, a composition containing the same and applications thereof. The present ?-agarase provides the field a novel alternative and is favorable for the industrial utilities of the hydrolysis products of agarose. Furthermore, the present agarase is particularly modified for heterologous production by prokaryotic expression systems, and thereby is favorable for commercial use.Type: ApplicationFiled: March 20, 2017Publication date: February 15, 2018Applicant: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: JIUNN-HORNG LIN, JYH-PERNG WANG, ZENG-WENG CHEN, HUI-JIE LIN, SHU-WEI CHANG, WENG-ZENG HUANG, JIAN-FONG LAI, SHIH-LING HSUAN
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Patent number: 9775893Abstract: Provided in the present invention are anti-Mycoplasma spp. subunit vaccines, especially proteins suitable for being used as the active ingredient of the Mycoplasma spp. subunit vaccines, and a vaccine prepared therefrom. Upon experimenting, it is confirmed that the proteins can elicit an immune response having sufficient strength to avoid the infection of Mycoplasma spp. in pigs. The vaccine can comprise one of the aforementioned proteins as an active ingredient, or can comprise two or more of the proteins to form a form of cocktail vaccine. The vaccine of the present invention is not only more safe than conventional vaccines, but also has equivalent or even better immune effects.Type: GrantFiled: March 8, 2017Date of Patent: October 3, 2017Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Ming-Wei Hsieh, Zeng-Weng Chen, Chien-Yu Fang, Hsueh-Tao Liu, Ping-Cheng Yang
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Patent number: 9757441Abstract: Provided in the present invention are anti-Mycoplasma spp. subunit vaccines, especially proteins suitable for being used as the active ingredient of the Mycoplasma spp. subunit vaccines, and a vaccine prepared therefrom. Upon experimenting, it is confirmed that the proteins can elicit an immune response having sufficient strength to avoid the infection of Mycoplasma spp. in pigs. The vaccine can comprise one of the aforementioned proteins as an active ingredient, or can comprise two or more of the proteins to form a form of cocktail vaccine. The vaccine of the present invention is not only more safe than conventional vaccines, but also has equivalent or even better immune effects.Type: GrantFiled: March 8, 2017Date of Patent: September 12, 2017Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Ming-Wei Hsieh, Zeng-Weng Chen, Chien-Yu Fang, Hsueh-Tao Liu, Ping-Cheng Yang
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Patent number: 9750790Abstract: Provided in the present invention are anti-Mycoplasma spp. subunit vaccines, especially proteins suitable for being used as the active ingredient of the Mycoplasma spp. subunit vaccines, and a vaccine prepared therefrom. Upon experimenting, it is confirmed that the proteins can elicit an immune response having sufficient strength to avoid the infection of Mycoplasma spp. in pigs. The vaccine can comprise one of the aforementioned proteins as an active ingredient, or can comprise two or more of the proteins to form a form of cocktail vaccine. The vaccine of the present invention is not only more safe than conventional vaccines, but also has equivalent or even better immune effects.Type: GrantFiled: December 19, 2016Date of Patent: September 5, 2017Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Jyh-Perng Wang, Ming-Wei Hsieh, Zeng-Weng Chen, Chien-Yu Fang, Hsueh-Tao Liu, Ping-Cheng Yang