Abstract: A nonvolatile semiconductor memory device includes a plurality of blocks each having a nonvolatile memory cell array, and a program potential generating circuit which supplies a program potential to the nonvolatile memory cell array, wherein the program potential generating circuit adjusts the program potential according to a first address signal selecting one of the blocks and a second address signal indicating a position of a write-accessed memory cell in the noted one of the blocks.

Abstract: A nonvolatile semiconductor memory device includes a plurality of blocks each having a nonvolatile memory cell array, and a program potential generating circuit which supplies a program potential to the nonvolatile memory cell array, wherein the program potential generating circuit adjusts the program potential according to a first address signal selecting one of the blocks and a second address signal indicating a position of a write-accessed memory cell in the noted one of the blocks.

Abstract: The present invention relates to a new mutant strain induced from a wild strain of the genus Escherichia, which is active upon a .gamma.-glutamyl-L-cystein synthesizing enzyme system and capable of releasing .gamma.-glutamyl-L-cystein synthetase from inhibition by glutathione.It preferably is Escherichia coli RC 912 (FERM-BP No. 47). The present invention also contemplates the preparation of glutathione by (1) culturing the foregoing strain in a culture medium' or (2) culturing said strain to first accumulate a .gamma.-glutamyl-L-cystein synthesizing enzyme system, and placing the latter into contact with a substrate of L-glutamic acid, L-cysteine and glycerine to form gluthatione by enzymatic reaction.

Abstract: Novel 2-oxo-imidazolidine derivative of the formula: ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl, R.sup.2 is lower alkyl, R.sup.3 is alkyl of one to 12 carbon atoms or phenyl-lower alkyl and R.sup.4 is hydrogen or lower alkyl, and a pharmaceutically acceptable salts thereof are disclsoed. Said compounds (I) and salts thereof are useful as hypotensive agents.

Abstract: A 2-oxoimidazolidine derivative of the formula: ##STR1## wherein R.sup.1 is lower alkyl or phenyl-lower alkyl and R.sup.2 is lower alkyl or phenyl, and a process for preparation thereof are disclosed. Said 2-oxoimidazolidine derivative (I) or a pharmaceutically acceptable salt thereof is useful as a hypotensive agent.

Abstract: Ethanol is produced in high concentration of 75 mg/ml or above such as 200 mg/ml by using an immbolized ethanol-producing microorganism to convert sugar to ethanol in a nutrient culture broth containing not more than 100 mg/ml sugar until the concentration of sugar is not more than 20% of its initial concentration, then adding a fresh culture broth containing not less than 100 mg/ml sugar and converting sugar to ethanol with the immobilized microorganism to produce the desired high concentration of ethanol. The microorganism is preferably immobilized in a sulfated polysaccharide gel as a dense layer near the surface of the gel.

Abstract: A tetrahydroisoquinoline compound of the formula: ##STR1## wherein R.sup.1 is alkyl of one to six carbon atoms, cycloalkyl of three to six carbon atoms, allyl or propargyl, R.sup.2 is hydrogen or alkyl of one to six carbon atoms, and R.sup.3 is hydrogen, alkyl of one to six carbon atoms or benzyl. Methods for preparing the compound (I) are disclosed. The compound (I) and a pharmaceutically acceptable salt thereof are useful as a diagnostic or therapeutic agent for angiotensin-related hypertension.

Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or methyl, is prepared by condensing a compound of the formula: ##STR2## wherein R.sup.2 is alkyl, aryl or aralkyl and R.sup.1 is same as above, or a reactive derivative thereof with 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid or an ester thereof to give a compound of the formula: ##STR3## wherein R.sup.3 is an ester residue and R.sup.1 and R.sup.2 are same as above, followed by hydrolysis or ammonolysis of said compound (IV). The compound (I) is useful as a diagnostic or therapeutic agent for angiotensin-related hypertension.