Patents by Inventor Jyun-Hung Chen

Jyun-Hung Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS
    Publication number: 20150099720
    Abstract: Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 9, 2015
    Inventors: Lin Zhi, Robert I. Higuchi, E. Adam Kallel, Cornelis Arjan Van Oeveren, Jyun-Hung Chen, Daniel A. Ruppar, Bijan Pedram, Thomas Lot Stevens Lau, Todd A. Miller
  • ANDROGEN RECEPTOR MODULATOR COMPOUNDS AND METHODS
    Publication number: 20140005186
    Abstract: Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Application
    Filed: August 23, 2013
    Publication date: January 2, 2014
    Applicant: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Robert I. Higuchi, E. Adam Kallel, Cornelis Arjan Van Oeveren, Jyun-Hung Chen, Daniel A. Ruppar, Bijan Pedram, Thomas Lot Stevens Lau, Todd A. Miller
  • Tricyclic androgen receptor modulator compounds and methods
    Publication number: 20100210678
    Abstract: Provided are non-steroidal tricyclic compounds that are modulators of androgen receptors and methods for making and using such compounds.
    Type: Application
    Filed: March 19, 2010
    Publication date: August 19, 2010
    Inventors: Lin Zhi, Cornelis Arjan Van Oeveren, Jyun-Hung Chen, Robert I. Higuchi
  • Thrombopoietin activity modulating compounds and methods
    Patent number: 7691895
    Abstract: Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: April 6, 2010
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Jyun-Hung Chen, E. Adam Kallel, Thomas Lau, Matthew H. McNeill, Todd A. Miller, Bao N. Nguyen, Richard J. Penulian, Dean P. Phillips, Daniel A. Ruppar, Lin Zhi, Jackline E. Dalgard
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20080300241
    Abstract: Non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: November 17, 2006
    Publication date: December 4, 2008
    Inventors: Robert Higuchi, Lin Zhi, Donald Karanewsky, Anthony Thompson, Thomas Caferro, Neelakandha Mani, Jyun-Hung Chen, Marquis Cummings, James Edwards, Mark Adams, Charlotte Deckhut
  • THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS
    Publication number: 20080146594
    Abstract: Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Application
    Filed: November 8, 2007
    Publication date: June 19, 2008
    Applicant: Ligand Pharmaceutical, Inc.
    Inventors: Jyun-Hung Chen, E. Adam Kallel, Thomas Lau, Matthew H. McNeill, Todd A. Miller, Bao N. Nguyen, Richard J. Penuliar, Dean P. Phillips, Daniel A. Ruppar, Lin Zhi, Jackline E. Dalgard
  • THROMBOPOIETIN ACTIVITY MODULATING COMPOUNDS AND METHODS
    Publication number: 20080103190
    Abstract: Disclosed herein are compounds, pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Application
    Filed: December 21, 2007
    Publication date: May 1, 2008
    Applicant: Ligand Pharmaceuticals, Inc.
    Inventors: Jyun-Hung Chen, E. Kallel, Thomas Lau, Matthew McNeill, Todd Miller, Bao Nguyen, Richard Penuliar, Dean Phillips, Daniel Ruppar, Lin Zhi, Jackline Dalgard
  • Thrombopoietin activity modulating compounds and methods
    Patent number: 7314887
    Abstract: Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Grant
    Filed: October 21, 2005
    Date of Patent: January 1, 2008
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Jyun-Hung Chen, E. Adam Kallel, Thomas Lau, Matthew H. McNeill, Todd A. Miller, Bao N. Nguyen, Richard J. Penuliar, Dean P. Phillips, Daniel A. Ruppar, Lin Zhi, Jackline E. Dalgard
  • Tricyclic androgen receptor modulator compounds and methods
    Publication number: 20070293528
    Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
    Type: Application
    Filed: January 31, 2006
    Publication date: December 20, 2007
    Inventors: Lin Zhi, Cornelis Van Oeveren, Jyun-Hung Chen, Robert Higuchi
  • Androgen Receptor Modulator Compounds and Methods
    Publication number: 20070254875
    Abstract: Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Application
    Filed: March 11, 2005
    Publication date: November 1, 2007
    Inventors: Lin Zhi, Robert Higuchi, E. Kallel, Cornelis Van Oeveren, Jyun-Hung Chen, Daniel Ruppar, Bijan Pedram, Thomas Stevens Lau, T. Miller
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Patent number: 7214690
    Abstract: Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: May 8, 2007
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Robert I. Higuchi, Lin Zhi, Donald S. Karanewsky, Anthony W. Thompson, Thomas R. Caferro, Neelakandha S. Mani, Jyun-Hung Chen, Marquis L. Cummings, James P. Edwards, Mark E. Adams, Charlotte L. F. Deckhut
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20070072849
    Abstract: Non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: November 17, 2006
    Publication date: March 29, 2007
    Inventors: Robert Higuchi, Lin Zhi, Donald Karanewsky, Anthony Thompson, Thomas Caferro, Neelakandha Mani, Jyun-Hung Chen, Marquis Cummings, James Edwards, Mark Adams, Charlotte Deckhut
  • Tricyclic androgen receptor modulator compounds and methods
    Publication number: 20060128740
    Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
    Type: Application
    Filed: January 31, 2006
    Publication date: June 15, 2006
    Inventors: Lin Zhi, Cornelis Van Oeveren, Jyun-Hung Chen, Robert Higuchi
  • Thrombopoietin activity modulating compounds and methods
    Publication number: 20060116417
    Abstract: Disclosed herein are compounds of Formula (I), (II), and (III) pharmaceutical compositions comprising the same, methods of modulating the activity a thrombopoietin receptor using the same, methods of identifying compounds as thrombopoietin receptor modulators, and methods of treating disease by administering a compound of the invention to a patient in need thereof.
    Type: Application
    Filed: October 21, 2005
    Publication date: June 1, 2006
    Inventors: Jyun-Hung Chen, E. Kallel, Thomas Lau, Matthew McNeill, Todd Miller, Bao Nguyen, Richard Penuliar, Dean Phillips, Daniel Ruppar, Lin Zhi, Jackline Dalgard
  • Tricyclic androgen receptor modulator compounds and methods
    Patent number: 7026484
    Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: April 11, 2006
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Cornelis Arjan Van Oeveren, Jyun-Hung Chen, Robert I. Higuchi
  • Fluorinated trienes and their use as rxr modulators
    Publication number: 20040248919
    Abstract: The present invention relates to a method of modulating retinoid X receptor activity in a mammal, novel compounds and pharmaceutical compositions for modulating retinoid X receptor activity in a mammal, and methods of making compounds that modulate retinoid X receptor activity in a mammal. The compounds are represented by Structural Formula 1: The compounds of Structural Formual 1 are efficacious insulin sensitizers and do not have the undesirable side effects of increasing triglycerides or suppressing the thyroid hormone axis.
    Type: Application
    Filed: April 15, 2004
    Publication date: December 9, 2004
    Inventors: Michael Gregory Bell, Timothy Alan Grese, Douglas Linn Gernett, Nathan P. Yumibe, Marcus F. Boehm, Pierre-Yves Michellys, Robert J. Ardecky, Christopher M Mapes, Jyun-Hung Chen, John S. Tyhonas, Lawrence G. Hamann
  • RXR modulators with improved pharmacologic profile
    Patent number: 6593493
    Abstract: The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently claimed modulators. The present invention also provides synthetic methods for preparing these compounds as well as pharmaceutical compositions incorporating these novel compounds and methods for the therapeutic use of such compounds and pharmaceutical compositions.
    Type: Grant
    Filed: September 14, 2000
    Date of Patent: July 15, 2003
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Robert J. Ardecky, Marcus F. Boehm, Amy L. Faulkner, Lawrence G. Hamann, Todd K. Jones, Christopher M. Mapes, Pierre-Yves Michellys, John S. Tyhonas, Anthony W. Thompson, Jyun-Hung Chen
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20020183314
    Abstract: Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: February 22, 2002
    Publication date: December 5, 2002
    Applicant: Ligand Pharmaceuticals Incorporated
    Inventors: Robert I. Higuchi, Lin Zhi, Donald S. Karanewsky, Anthony W. Thompson, Thomas R. Caferro, Neelakandha S. Mani, Jyun-Hung Chen, Marquis L. Cummings, James P. Edwards, Mark E. Adams, Charlotte L.F. Deckhut
  • Tricyclic androgen receptor modulator compounds and methods
    Publication number: 20020183346
    Abstract: This invention relates to non-steroidal tricyclic compounds that are modulators of androgen receptors and to methods for making and using such compounds.
    Type: Application
    Filed: February 22, 2002
    Publication date: December 5, 2002
    Applicant: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Cornelis Arjan Van Oeveren, Jyun-Hung Chen, Robert I. Higuchi