Patents by Inventor Jyun-Yuan Huang

Jyun-Yuan Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant DNA polymerase for improved incorporation of nucleotide analogues
    Patent number: 10662413
    Abstract: A composition comprising a recombinant DNA polymerase and 3?-esterified nucleotide analogues is provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9° N DNA polymerase (SEQ ID NO: 1), and the recombinant DNA polymerase includes at least two mutations at the positions corresponding to amino acid residues 141 and 143 of the 9° N DNA polymerase. A recombinant DNA polymerase is further provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9° N-III DNA polymerase (SEQ ID NO: 3), and the recombinant DNA polymerase includes one or two mutations at the positions corresponding to amino acid residue 480 and 486 of the 9° N-III DNA polymerase. A method of performing a polymerization reaction is also provided.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: May 26, 2020
    Assignee: PERSONAL GENOMICS, INC.
    Inventors: Shiuan-Woei Lin Wu, Ching-Wei Tsai, Ting-Yueh Tsai, Jyun-Yuan Huang, Chao-Chi Pan, Li-Chi Chang, Ching-Long Hwong
  • RECOMBINANT DNA POLYMERASE FOR IMPROVED INCORPORATION OF NUCLEOTIDE ANALOGUES
    Publication number: 20180119115
    Abstract: A composition comprising a recombinant DNA polymerase and 3?-esterified nucleotide analogues is provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9° N DNA polymerase (SEQ ID NO: 1), and the recombinant DNA polymerase includes at least two mutations at the positions corresponding to amino acid residues 141 and 143 of the 9° N DNA polymerase. A recombinant DNA polymerase is further provided. The recombinant DNA polymerase includes an amino acid sequence that is at least 90% homology with 9° N-III DNA polymerase (SEQ ID NO: 3), and the recombinant DNA polymerase includes one or two mutations at the positions corresponding to amino acid residue 480 and 486 of the 9° N-III DNA polymerase. A method of performing a polymerization reaction is also provided.
    Type: Application
    Filed: October 31, 2017
    Publication date: May 3, 2018
    Inventors: Shiuan-Woei LIN WU, Ching-Wei TSAI, Ting-Yueh TSAI, Jyun-Yuan HUANG, Chao-Chi PAN, Li-Chi CHANG, Ching-Long HWONG
  • Treating hepatitis virus infection by modulating microRNAs miR-130a, miR-130b, miR-204, or miR-1236
    Patent number: 9771589
    Abstract: Methods and pharmaceutical compositions for regulating hepatitis virus replication, involving a miR-130a RNA, a miR-130b RNA, a miR-204 RNA, a miR-1236 RNA, or a combination thereof.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: September 26, 2017
    Assignee: Academia Sinica
    Inventors: Chiaho Shih, Jyun-Yuan Huang
  • TREATING HEPATITIS VIRUS INFECTION BY MODULATING MICRORNAS MIR-130A, MIR-130B, MIR-204, OR MIR-1236
    Publication number: 20160251661
    Abstract: Methods and pharmaceutical compositions for regulating hepatitis virus replication, involving a miR-130a RNA, a miR-130b RNA, a miR-204 RNA, a miR-1236 RNA, or a combination thereof.
    Type: Application
    Filed: September 19, 2014
    Publication date: September 1, 2016
    Applicant: Academia Sinica
    Inventors: Chiaho Shih, Jyun-Yuan Huang
  • TREATING DISEASES ASSOCIATED WITH PGC1-ALPHA BY MODULATING MICRORNAS MIR-130A AND MIR-130B
    Publication number: 20160244755
    Abstract: Methods of regulating PGC1? and/or PGC1?, or treating diseases associated with PGC1? and/or PGC1? using a miR-130a RNA, miR-130b RNA, or a combination thereof, or using an antagomiR of miR-130a, an antagomiR of miR-130b, or both, which can be in the form of microRNA sponge or a locked nucleic acid (LNA).
    Type: Application
    Filed: September 19, 2014
    Publication date: August 25, 2016
    Inventors: Chiaho Shih, Jyun-Yuan Huang