Abstract: Techniques for improving the handling of peripherals in a computer system, including through the use of a DMA control circuit that helps manage the flow of data between memory and the peripherals via an intermediate storage buffer. The DMA control circuit is configured to control timing of DMA transfers between sample buffers in the memory and the intermediate storage buffer. The DMA control circuit may output a priority value of the DMA control circuit for accesses to memory, where the priority value based on stored quality of service (QoS) information and current channel data buffer levels for different DMA channels. The DMA control circuit may separately arbitrate between multiple active transmit and receive channels. Still further, the DMA control circuit may store, for a given data transfer over a particular DMA channel, timestamp information indicative of completion of the DMA and peripheral-side operations.

Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: Disclosed herein are quantum dot devices, as well as related computing devices and methods. For example, in some embodiments, a quantum dot device may include: a quantum well stack; a first gate above the quantum well stack, wherein the first gate includes a first gate metal and a first gate dielectric; and a second gate above the quantum well stack, wherein the second gate includes a second gate metal and a second gate dielectric, and the first gate is at least partially between a portion of the second gate and the quantum well stack.

Abstract: Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC50s on one axis, and the non-mutated amino acid sequence IC50s on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described.

Abstract: A tool assembly includes an anvil and a cartridge assembly movable from an open position to a closed position, and a locking member movably supported on a distal portion of the cartridge assembly. The locking member is configured to move into a slot of the anvil as the anvil and cartridge assembly move toward the closed position to set a gap distance between the anvil and cartridge assembly.

Abstract: An end effector for a surgical stapling apparatus includes a cartridge assembly and an anvil assembly. The cartridge assembly includes a cartridge channel supporting a reload. The cartridge assembly can include a cartridge channel that supports the reload. The cartridge assembly can include a hinge assembly that pivotally couples to the cartridge channel.

Abstract: A surgical access assembly includes an elongated cannula member having a proximal end portion and a distal end portion, a balloon anchor coupled to the distal end portion of the elongated cannula member, a sleeve of the balloon anchor extending proximally along an outer surface of the elongated cannula member, a chamber defined between the sleeve of the balloon anchor and the outer surface of the elongated cannula member, and a first collar is coupled to the elongated cannula member. The first collar is slidable along the elongated cannula member and engageable with the sleeve of the balloon anchor.

Abstract: An end effector for a surgical stapling apparatus includes a cartridge assembly and an anvil assembly. The cartridge assembly includes a cartridge channel supporting a reload. The reload includes a plurality of separate and distinct cartridge units that removably interconnect with one another within the cartridge channel. The cartridge assembly can include a cartridge channel that supports the reload and a hinge assembly that pivotally couples to the cartridge channel.

Abstract: A digital-to-analog converter has a first interface coupled to a second interface through one or more modulation circuits. The circuits include a first coupler connected to the first interface; a first waveguide with a first lead connected to the first coupler, a first end, and a first length running therebetween. The first lead and the first end are coupled by a first switch. The circuits also include: a second coupler connected to the first interface; a second waveguide having a second lead connected to the second coupler, a second end, and a second length running therebetween, the second lead and the second end coupled by a second switch along the second length; and an optical combiner connected to the ends of the waveguides. The second interface is connected to the optical combiner of the modulation circuits. Output from the second interface is an optical signal capable of carrying binary information.

Abstract: A cartridge assembly for a surgical stapling device includes a staple cartridge that includes a staple array that has a configuration to minimize blood leakage through a staple line formed by the staple cartridge.

Abstract: An end effector of a surgical stapling apparatus includes an anvil assembly and a cartridge assembly. The anvil assembly has an anvil body that supports an anvil buttress. The anvil buttress includes a distal alignment band that extends distally beyond the anvil body. The cartridge assembly has a cartridge body that supports a cartridge buttress. The cartridge buttress includes a distal alignment band that extends distally beyond the cartridge body.

Abstract: The ability to rapidly identify symmetry and anti-symmetry is an essential attribute of intelligence. Symmetry perception is a central process in human vision and may be key to human 3D visualization. While previous work in understanding neuron symmetry perception has concentrated on the neuron as an integrator, the invention provides the coincidence detecting property of the spiking neuron can be used to reveal symmetry density in spatial data. A synchronized symmetry-identifying spiking artificial neural network enables layering and feedback in the network. The network of the invention can identify symmetry density between sets of data and present a digital logic implementation demonstrating an 8×8 leaky-integrate-and-fire symmetry detector in a field-programmable gate array. The efficiency of spiking neural networks can be harnessed to rapidly identify symmetry in spatial data with applications in image processing, 3D computer vision, and robotics.

Abstract: A cuff is described for a target anatomic feature within a body, along with a system for utilizing the cuff. The cuff includes a band defining a circumferential opening extending along a length of the band; and a pair of engagement surfaces defined by or affixed to the cuff, the engagement surfaces structured for application of a spreading force to be distributed continuously along a portion of the circumferential opening, thereby increasing the circumferential opening and expanding the cuff for a closed configuration to an open configuration sized for placement of the cuff. The cuff is structured to remain in the closed configuration in the absence of the spreading force and automatically return to the closed configuration after removal of the spreading force.

Abstract: A surgical access device includes an elongate tubular member with a proximal region and a distal region. A passage extends through the elongate tubular member. The surgical access device also includes a balloon anchor with an expandable portion. A first portion of the balloon anchor extends proximally along the outer surface of the tubular member. The surgical access device also has a valve assembly disposed in the proximal region of the elongate tubular member that is fluidly coupled to the balloon anchor. A disc is slidably disposed on the elongate tubular member and includes a first blade with a first sharpened edge that is configured to penetrate the first portion of the balloon anchor. The first blade is transitionable between a retracted position and an extended position.

Abstract: Methods and systems for computed tomography provide advances in efficiency. The methods operating within the parallel-beam geometry, rather than a divergent beam geometry, for the majority of the operations. In back projection methods perform digital image coordinate transformations on selected intermediate-images, the parameters of one or more coordinate transformations being chosen such that Fourier spectral support of the intermediate-image is modified so that a region of interest has an increased extent along one or more coordinate direction and the aggregates of the intermediate-images can be represented with a desired accuracy by sparse samples.

Abstract: A stop member for use with a surgical stapling device includes a plurality of sections that are releasably coupled to each other. Each of the sections includes a coupling member that can be selectively coupled to a tool assembly of the surgical stapling device to limit an actuation stroke of a drive assembly of the stapling device. Sections of the stop member can be removed from the stop member to change the position of a stop surface of the stop member on the tool assembly to change the effective stroke length of the clamp member.

Abstract: A lead device is provided for a medical treatment apparatus, where the lead device includes protruding anchoring mechanisms for anchoring the lead device in tissue. The anchoring mechanism include permanent anchoring mechanisms, or a combination of permanent and dissolvable anchoring mechanisms, to anchor the device in tissue. The anchoring mechanism resists migration of the lead device in at least one or both axial directions.

Abstract: The present invention relates to a stable formulation of Cetrorelix or its pharmaceutically acceptable salt in the form of ready-to-use solution. The said stable ready-to-use solution of Cetrorelix prevents gel formation and provides better patient compliance. Further, the invention relates to a process for preparation of the said stable ready-to-use solution of Cetrorelix.

Abstract: A tool assembly includes an anvil and a cartridge assembly movable from an open position to a closed position, and a locking member movably supported on a distal portion of the cartridge assembly. The locking member is configured to move into a slot of the anvil as the anvil and cartridge assembly move toward the closed position to set a gap distance between the anvil and cartridge assembly.

Abstract: An end effector for a surgical stapling apparatus includes a cartridge assembly and an anvil assembly. The cartridge assembly includes a cartridge channel supporting a reload. The reload includes a plurality of separate and distinct cartridge units that removably interconnect with one another within the cartridge channel. The cartridge assembly can include a cartridge channel that supports the reload and a hinge assembly that pivotally couples to the cartridge channel.