Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.

Abstract: A hanging hook for attaching a generally vertical object to a vertical side wall of a piece of storage furniture, comprises: a central portion extending laterally for at least the distance of the width of said object; a first attachment portion at one end of said central portion, the first attachment portion including a leg section extending downward for securing said leg portion through an aperture in a top surface of said piece of storage furniture; and a second attachment portions at the opposite end of said central portion, the second attachment portion including a leg section extending downward and an arm section extending inward from a distal end of the first section toward the center of said hanging hook for securing said arm section through an aperture in an outer side surface of said object.

Abstract: A hanging hook for attaching a generally vertical object to a vertical side wall of a piece of storage furniture, comprises: a central portion extending laterally for at least the distance of the width of said object; a first attachment portion at one end of said central portion, the first attachment portion including a leg section extending downward for securing said leg portion through an aperture in a top surface of said piece of storage furniture; and a second attachment portions at the opposite end of said central portion, the second attachment portion including a leg section extending downward and an arm section extending inward from a distal end of the first section toward the center of said hanging hook for securing said arm section through an aperture in an outer side surface of said object.

Abstract: A spinning reel for fishing includes: a reel body; a pinion rotated in response to a rotation of a handle; a rotary cylinder shaft integrally rotated with a rotor including a fishing line guide portion, the rotary cylinder shaft being rotatably supported in the reel body; a spool shaft including a spool at an end portion thereof, the spool shaft being inserted into the rotary cylinder shaft so that so that the spool shaft can be reciprocated in an axial direction thereof; a recessed portion formed in the axial direction on an inner circumference side of the rotary cylinder shaft; and a pair of rolling bearings arranged so as to be separated from each other in the axial direction between the recessed portion and an outer circumferential face of the spool shaft.

Abstract: A spinning reel for fishing includes: a reel body; a pinion rotated in response to a rotation of a handle; a rotary cylinder shaft integrally rotated with a rotor including a fishing line guide portion, the rotary cylinder shaft being rotatably supported in the reel body; a spool shaft including a spool at an end portion thereof, the spool shaft being inserted into the rotary cylinder shaft so that so that the spool shaft can be reciprocated in an axial direction thereof; a recessed portion formed in the axial direction on an inner circumference side of the rotary cylinder shaft; and a pair of rolling bearings arranged so as to be separated from each other in the axial direction between the recessed portion and an outer circumferential face of the spool shaft.