Abstract: There are disclosed compounds of the formula I: or a pharmaceutically acceptable salt of the compound, which exhibit anti-inflammatory and immunomodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds.

Abstract: The present invention relates to a method of intelligent 2D and 3D object and scene modeling, transformation and manipulation and more particularly this invention relates to the field of computer modeling, virtual reality, animation and 3D Web streaming. The method uses attributed hypergraph representations (AHR) for modeling, transforming and manipulating objects. From one or more 2D views of a 3D object or scene, range information is first computed and then a triangular mesh model is constructed. The data structure is designed to handle the transformations on the representation corresponding to movements and deformations of the object. In an attributed hypergraph, the attributes associated with the hyperedges and the vertices facilitates modeling of various shapes with geometrical, physical or behavior features.

Abstract: A non-sharp vascular infusion device and related method are disclosed. The non-sharp vascular infusion device permits medicine to be introduced into an IV assembly without creating a danger to healthcare personnel.

Abstract: There are disclosed compounds of the formula I: 1

Abstract: The present invention relates to the relation of the BRG1 gene (also called SNF2&agr;) to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the BRG1 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Abstract: The present invention relates to the relation of the TMPRSS2 gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the TMPRSS2 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Abstract: The present invention relates to a method of intelligent 2D and 3D object and scene modeling, transformation and manipulation and more particularly this invention relates to the field of computer modeling, virtual reality, animation and 3D Web streaming. The method uses attributed hypergraph representations (AHR) for modeling, transforming and manipulating objects. From one or more 2D views of a 3D object or scene, range information is first computed and then a triangular mesh model is constructed. The data structure is designed to handle the transformations on the representation corresponding to movements and deformations of the object. In an attributed hypergraph, the attributes associated with the hyperedges and the vertices facilitates modeling of various shapes with geometrical, physical or behavior features.

Abstract: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to human CDC14A gene which has been found to be mutated in certain tumor cell lines. More specifically, the invention relates to a novel sequence for the human CDC14A gene. The present invention further relates to somatic mutations in the CDC14A gene in human cancer and their use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the CDC14A gene, including gene therapy, protein replacement therapy and protein mimetics. The invention further relates to the screening of drugs for cancer therapy. Finally, the invention relates to the screening of the CDC14A gene for mutations, which are useful for diagnosing the predisposition to cancer.

Abstract: A simulated shoulder is provided for purposes of creating a costume. The shoulder includes a platform having an upper and a lower surface, horizontally disposed support columns defining the periphery of the shoulder platform, and a head supporting structure attached to the upper surface for support of an inflatable bladder. The inflatable bladder is attached to the head supporting structure and simulates a head or supports a costume mask. An elongated support column extends downwardly from the platform. The support column is attached at one end to the platform and spaced apart a sufficient lateral distance so as to accommodate a wearer's head. There is also provided an adjustable flexible strap attached to the support columns to hold the structure to a wearer and for supporting the shoulder platform.

Abstract: Recent evidence indicates that the carboxy-terminal region of the tumor suppressor protein BRCA1 is a functionally significant domain. Using the yeast two-hybrid assay and an in vitro biochemical assay, it is here shown that a protein, B112, interacts specifically with the carboxy-terminal segment of human BRCA1 from residue 1602 to 1863. A germ line truncation mutation, 1853ter, that removes the last 11 amino acids from the carboxy-terminus of BRCA1 abolishes not only the transcription activation function, but also binding to B112. The B112 protein is apparently the same as an uncharacterized protein known as CtIP, the sequence of which was previously deposited in GenBank. Screenings of a panel of 92 tumor cell lines for mutations in the B112/CtIP sequence have identified a number of missense variants, including a non-conserved lysine to glutamic acid change at codon 337 in the pancreatic cancer line, BxPC3.

Abstract: A simulated shoulder is provided for purposes of creating a costume. The shoulder includes a platform having an upper and a lower surface, horizontally disposed support columns defining the periphery of the shoulder platform, and a head supporting structure attached to the upper surface for support of an inflatable bladder. The inflatable bladder is attached to the head supporting structure and simulates a head or supports a costume mask. An elongated support column extends downwardly from the platform. The support column is attached at one end to the platform and spaced apart a sufficient lateral distance so as to accommodate a wearer's head. There is also provided an adjustable flexible strap attached to the support columns to hold the structure to a wearer and for supporting the shoulder platform.

Abstract: The present invention relates to the relation of the TMPRSS2 gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the TMPRSS2 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Abstract: Recent evidence indicates that the carboxy-terminal region of the tumor suppressor protein BRCA1 is a functionally significant domain. Using the yeast two-hybrid assay and an in vitro biochemical assay, it is here shown that a protein, B112, interacts specifically with the carboxy-terminal segment of human BRCA1 from residue 1602 to 1863. A germ line truncation mutation, 1853ter, that removes the last 11 amino acids from the carboxy-terminus of BRCA1 abolishes not only the transcription activation function, but also binding to B112. The B112 protein is apparently the same as an uncharacterized protein known as CtIP, the sequence of which was previously deposited in GenBank. Screenings of a panel of 92 tumor cell lines for mutations in the B112/CtIP sequence have identified a number of missense variants, including a non-conserved lysine to glutamic acid change at codon 337 in the pancreatic cancer line, BxPC3.

Abstract: A 3D vision system utilizes a CCD camera to first generate a two dimensional image of the object. A computer analyzes the two dimensional image to determine areas of interest, such as high contrast areas which indicate sharp discontinuities. A laser range scanner, controlled by the computer, then scans the object at a variable resolution, increasing its resolution in the areas of interest to generate a computer model.

Abstract: Automatic discovery of qualitative and quantitative patterns inherent in data sets is accomplished by use of a unified framework which employs adjusted residual analysis in statistics to test the significance of the pattern candidates generated from data sets. This framework consists of a search engine for different order patterns, a mechanism to avoid exhaustive search by eliminating impossible pattern candidates, an attributed hypergraph (AHG) based knowledge representation language and an inference engine which measures the weight of evidence of each pattern for classification and prediction. If a pattern candidate passes the statistical significance test of adjusted residual, it is regarded as a pattern and represented by an attributed hyperedge in AHG. In the task of classification and/or prediction, the weights of evidence are calculated and compared to draw the conclusion.

Abstract: A method of bonding a contoured seat cover with a first surface to a seat cushion with a second surface is provided which includes the steps of coating the second surface with a heat-activated adhesive, placing a flexible planar heating member between the first and second surfaces, pressing the first and second surfaces together against the heater with a force of one to five pounds per square inch, heating the adhesive with the heating member, removing the heating member while the first and second surfaces are pressed together, and allowing the adhesive to solidify and then relieving the pressure between the seat cover and the seat cushion.

Abstract: A coupling connector relies on inductive and capacitive coupling over a length L.sub.c to "connect" signals from a first circuit card to a second circuit card. The coupling connector includes a flex circuit which in a connected state is compressed to provide a coupling length L.sub.c between the first and second circuit cards. A typical application is for coupling cards to a backplane having a plurality of parallel, signal carrying tracks. The near end of each coupling track is input to a receiver having an input impedance equal to the characteristic impedance of the coupling track. The far end of the coupling track is terminated by a resistor whose value equals the characteristic impedance of the coupling track.

Abstract: Traction is provided for automotive vehicles stuck in snow, mud, and the like by a device applied over the outer face of the slipping driven vehicle wheel and having J-shaped traction fingers draped over the tire of the wheel and fixedly clamped on the tire by merely swinging a lever. The device has a mounting plate for overlying the conventional wheel disk or hubcap, three J-shaped fingers pivoted to the center of the plate and radially guided in 120.degree. spaced apart relation at the periphery of the plate with the cups of the fingers receiving the tire and presenting outer tread surfaces which will bite into the slippery road bed. One of the fingers is retracted on its pivot by a lever or handle effective to clamp all three of the fingers on the tire.