Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.

Abstract: A medical instrument includes a tool extender used to retain and move a tool relative to a flexible elongate device. The tool extender includes a slider that allows a user to move the tool relative to a flexible elongate device with one hand using a portion of the slider that is configured to be engaged and manipulated by the user's hand or fingers.

Abstract: The various implementations described herein include methods and systems for synchronous audio playback. In one aspect, a method is performed at each of a plurality of electronic devices, each having an audio system, an internal clock, processors and memory storing programs for execution by the processors. Each device is configured for two-way communications with a server and associated with a user account. The device receives an identification of a first device as a common clock device that has a first internal clock being designated as a master clock. The device receives a synchronized audio playback command that includes audio data to be output and a future playback time. In response to receiving the audio data, the device determines a synchronized audio playback time. If the determined synchronized audio playback time has not yet occurred, the electronic device outputs the audio data based on the determined synchronized audio playback time.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include a plurality of absorbable filaments arranged in a support structure and configured degrade within a defined time period and a membrane arranged about the plurality of absorbable filaments and configured to contain fragments of the plurality of absorbable filaments in response to a fracture or degradation of a filament.

Abstract: A sole structure for an article of footwear includes a bladder having a plurality of tapered chambers including (a) a series of first tapered chambers tapering from a first end on a medial side of the bladder to a second end on a lateral side of the bladder, and (b) one or more second tapered chambers tapering from a first end on the lateral side of the bladder to a second end on the medial side of the bladder. Each of the one or more second tapered chambers is interposed between adjacent ones of the first tapered chambers. The sole structure also includes a chassis disposed on a first side of the bladder and having a plurality of first ribs each disposed between adjacent ones of the first tapered chambers and the second tapered chambers.

Abstract: An example image intensifier includes a quantum well infrared photodetector (QWIP) configured to receive photons to photoexcite carriers out of a localized quantum state; and a light emitting diode (LED), wherein the photoexcited carriers control the LED.

Abstract: A medical device for the treatment and irrigation of a sinus opening is described. The device allows for single-handed operation to access, dilate and irrigate a sinus opening. The device includes a sinus guide catheter, a guiding element, a balloon dilation catheter, a balloon catheter movement mechanism and a guiding element movement mechanism. A method for treating a sinus opening and irrigating a sinus is also described.

Abstract: A user device may provide, to a network associated with a base station, user device location data identifying a latitude, a longitude, and a heading of the user device, and may receive base station location data identifying a latitude, a longitude, and signal coverage of the base station. The user device may display a first user interface that includes a user device indication, a base station indication, and a selection option, and may receive a selection of the selection option. The user device may retrieve camera view data and sensor data associated with the user device and may display, based on the camera view data and the sensor data, a second user interface that includes the first user interface overlaid on a camera view of the user device, an augmented reality-based signal strength directional indicator, and an augmented reality-based base station location representation associated with the base station.

Abstract: A device for delivering fluid to a user includes a fluid reservoir for holding the fluid, the fluid reservoir defining an internal volume and a stopper positioned in the internal volume of the fluid reservoir, wherein the stopper is formed with a cavity. The device further includes a piston having a distal end received within the cavity of the stopper and an actuator coupled to the piston for driving the piston into the internal volume of the fluid reservoir. Also, the device includes a coupling device for engaging the piston in the cavity of the stopper at a desired position and a sensor for determining whether the piston is engaged in the cavity of the stopper at the desired position.

Abstract: A fluid-filled chamber includes first subchamber having a substantially U-shape. The fluid-filled chamber also includes a second subchamber having a substantially U-shape and being spaced apart from the first subchamber in a direction extending along a longitudinal axis of the fluid-filled chamber.

Abstract: A user equipment (UE) is configured to prioritize a plurality of Public Land Mobile Networks (PLMNs) from an aggregate roaming priority public land mobile network (RPPLMN) list containing the plurality of PLMNs into a plurality of prioritized PLMNs and connect to a selected PLMN from the plurality of prioritized PLMNs based on a priority of the selected PLMN. The UE is further configured to determine if an application processor (AP) assisted location service is available, wherein the AP-assisted service is configured to identify a plurality of deployed PLMNs and a plurality of frequencies used by the plurality of deployed PLMNs at a current geographical location of the UE and when the AP) assisted location service is available, determining if a registered PLMN (RPLMN) is valid in a current mobile country code (MCC).

Abstract: A fluid-filled chamber includes first subchamber having a substantially U-shape. The fluid-filled chamber also includes a second subchamber having a substantially U-shape and being spaced apart from the first subchamber in a direction extending along a longitudinal axis of the fluid-filled chamber.

Abstract: A medical device for the treatment and irrigation of a sinus opening is described. The device allows for single-handed operation to access, dilate and irrigate a sinus opening. The device includes a sinus guide catheter, a guiding element, a balloon dilation catheter, a balloon catheter movement mechanism and a guiding element movement mechanism. A method for treating a sinus opening and irrigating a sinus is also described.

Abstract: Arrangements of the innovation relate to a micro-coring system configured to harvest a plurality of cores, either sequentially or simultaneously. In one arrangement, the micro-coring system comprises a harvesting tool configured to harvest and transfer at least one tissue core from a donor site to a recipient site, the at least one tissue core having a diameter of between about 1.0 mm and 3.0 mm diameter. In one arrangement, the harvesting tool comprises: a coring tool configured to penetrate tissue at the donor site and capture a tissue core from the tissue, and an extractor pin disposed within an aperture extending along a longitudinal axis of the coring tool, the extractor pin configured to extract the core from the coring tool.

Abstract: A sole structure for an article of footwear includes a bladder having a plurality of tapered chambers including (a) a series of first tapered chambers tapering from a first end on a medial side of the bladder to a second end on a lateral side of the bladder, and (b) one or more second tapered chambers tapering from a first end on the lateral side of the bladder to a second end on the medial side of the bladder. Each of the one or more second tapered chambers is interposed between adjacent ones of the first tapered chambers. The sole structure also includes a chassis disposed on a first side of the bladder and having a plurality of first ribs each disposed between adjacent ones of the first tapered chambers and the second tapered chambers.

Abstract: A lavage catheter for the treatment of a maxillary sinus is described. The catheter comprises a proximal portion and a distal portion. The distal portion comprises an irrigation tip. The irrigation tip has a tip opening through which fluid may be delivered by one handed operation of the catheter. A method for lavaging the maxillary sinus includes inserting the lavage catheter into a patient's anatomy and advancing the irrigation tip into the maxillary sinus using one hand.

Abstract: A lavage catheter for the treatment of a maxillary sinus is described. The catheter comprises a proximal portion and a distal portion. The distal portion comprises an irrigation tip. The irrigation tip has a tip opening through which fluid may be delivered by one handed operation of the catheter. A method for lavaging the maxillary sinus includes inserting the lavage catheter into a patient's anatomy and advancing the irrigation tip into the maxillary sinus using one hand.

Abstract: Methods, systems, and apparatuses are described for a CMOS compatible substrate having multiple stacks of semiconductor layers. The multiple stacks, at least, each include i) a layer of a tellurium based semiconductor layer on top of ii) a porous silicon layer. The porous silicon layer is a compliant layer to accept structural defects from the tellurium based semiconductor layer into the porous silicon layer. The multiple stacks are grown on the CMOS compatible substrate.

Abstract: A device for delivering fluid to a user includes a fluid reservoir for holding the fluid, the fluid reservoir defining an internal volume and a stopper positioned in the internal volume of the fluid reservoir, wherein the stopper is formed with a cavity. The device further includes a piston having a distal end received within the cavity of the stopper and an actuator coupled to the piston for driving the piston into the internal volume of the fluid reservoir. Also, the device includes a coupling device for engaging the piston in the cavity of the stopper at a desired position and a sensor for determining whether the piston is engaged in the cavity of the stopper at the desired position.

Abstract: A bladder for an article of footwear extends from an anterior end to a posterior end and includes a first chamber disposed in an interior region of the bladder and a second chamber at least partially surrounding the first chamber. The first chamber includes a first interior void having a first pressure and the second chamber includes a second interior void having a second pressure. In some implementations, the second chamber includes a plurality of lobes arranged in series and each having a first end, a second end, and an intermediate portion disposed between the first end and the second end. Each lobe has a greater thickness at the intermediate portion than at the first end and the second end, such that each lobe tapers from the intermediate portion to the first end and the second end.