Abstract: The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.

Abstract: The compositions and methods of the present invention are based, in part, on our discovery that an effector function mediated by an Fc-containing polypeptide can be altered by modifying one or more amino acid residues within the polypeptide (by, for example, electrostatic optimization). The polypeptides that can be generated according to the methods of the invention are highly variable, and they can include antibodies and fusion proteins that contain an Fc region or a biologically active portion thereof.

Abstract: A system for wireless asset tracking is disclosed. The system includes a plurality of mobile devices. Each mobile device performs two spreading operations with two distinct PN codes, a first PN code and a second PN code. Data is transmitted by each mobile device using a burst direct sequence spread spectrum radio signal. The system also includes at least three base stations. Each base station is configured to receive the burst direct sequence spread spectrum radio signals from the mobile devices which includes decoding the signals by first de-spreading with the second PN code and second de-spreading with the first PN code. Each base station is further configured to add a timestamp to each data packet received. A system for calculating the location of the mobile devices creates location information for each mobile device by calculating the time difference of arrival of received bursts for each base station.

Abstract: Novel reagents are provided along with methods for their use in nucleic acid hybridization assays for detecting target nucleic acids in samples. The most preferred reagent is a mixture of guanidinium thiocyanate and tetramethylammonium:Trifluoracetate and possesses many properties for facilitating hybridization between target nucleic acid and nucleic acid probes capable of binding thereto and surprisingly results in the phenomenon of superstoichiometric labeling.

Abstract: Novel reagents are provided along with methods for their use in nucleic acid hybridization assays for detecting target nucleic acids in samples. The most preferred reagent is a mixture of guanidinium thiocyanate and tetramethylammonium:Trifluoracetate and possesses many properties for facilitating hybridization between target nucleic acid and nucleic acid probes capable of binding thereto and surprisingly results in the phenomenon of superstoichiometric labeling.