Abstract: Velocity detection is the crucial step for motion feedback and control. A dynamic loudspeaker can be conceptualized as a motion conductor within magnetic field. This invention calculates the velocity of a motion conductor, uses operational amplifier to emulate the calculation and realize the velocity detection.

Abstract: Compositions and methods are disclosed for targeted treatment of lung cancer-derived metastatic brain tumors. In particular, tumor targeting agents comprising targeting peptides are disclosed that can target a payload, such as a therapeutic or diagnostic agent, to lung cancer-derived metastatic brain tumors. Chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill lung cancer-derived metastatic brain tumors.

Abstract: An eyepiece for use in front of an eye of a viewer includes a waveguide having a surface and a diffractive optical element (DOE) optically coupled to the waveguide. The DOE includes a plurality of first ridges protruding from the surface of the waveguide and arranged as a periodic array having a period, each respective first ridge has a first height and a respective first width. The DOE also includes a plurality of second ridges, each respective second ridge protruding from a respective first ridge and having a second height greater than the first height and a respective second width less than the respective first width. At least one of the respective first width, the respective second width, or a respective ratio between the respective first width and the respective second width varies as a function of a distance from a first edge of the DOE.

Abstract: An eyepiece for use in front of an eye of a viewer includes a waveguide configured to propagate light therein, and a diffractive optical element optically coupled to the waveguide. The diffractive optical element includes a plurality of first ridges protruding from a surface of the waveguide. Each of the plurality of first ridges has a first height and a first width. The diffractive optical element further includes a plurality of second ridges. Each of the plurality of second ridges protrudes from a respective first ridge and has a second height greater than the first height and a second width less than the first width. The diffractive optical element is configured to diffract a portion of a light beam incident on the diffractive optical element toward the eye as a first order transmission.

Abstract: The subject matter contained herein relates to a programmable electronic display that can be controlled by a mobile device, such as a cell phone. Said display is configured to be placed for view outside a vehicle, such as the rear window of a car or a truck bed gate or on top of the roof of a car.

Abstract: Compositions and methods are disclosed for targeted treatment of lung cancer-derived metastatic brain tumors. In particular, tumor targeting agents comprising targeting peptides are disclosed that can target a payload, such as a therapeutic or diagnostic agent, to lung cancer-derived metastatic brain tumors. Chimeric antigen receptor (CAR) polypeptides are disclosed that can be used with adoptive cell transfer to target and kill lung cancer-derived metastatic brain tumors.

Abstract: The multiple maneuvering systems for various applications includes several embodiments of wheeled, multiple maneuvering systems including multiple parallel maneuvering systems (MPMS). Each MPMS includes two or more parallel maneuvering units (PMUs) attached to one another by a connecting structure. Each PMU includes two or more powered or non-powered wheels, with the wheels being maintained parallel to one another by a steering mechanism. The steering mechanism may include gears, belt and pulley, chain and sprocket, or a rigid linkage. The connecting structure may be rigid, linearly adjustable, rotatable adjustable or both linearly and rotatable adjustable. The adjustable connecting structures allow for relative movement between the PMUs, while maintaining a load support surface(s) of the MPMSs.

Abstract: An eyepiece for use in front of an eye of a viewer includes a waveguide configured to propagate light therein, and a diffractive optical element optically coupled to the waveguide. The diffractive optical element includes a plurality of first ridges protruding from a surface of the waveguide. Each of the plurality of first ridges has a first height and a first width. The diffractive optical element further includes a plurality of second ridges. Each of the plurality of second ridges protrudes from a respective first ridge and has a second height greater than the first height and a second width less than the first width. The diffractive optical element is configured to diffract a portion of a light beam incident on the diffractive optical element toward the eye as a first order transmission.

Abstract: The parallel maneuvering system is a steering system for portable devices, portable platforms and the like, allowing individual wheels to be steered in a parallel and simultaneous manner. The parallel maneuvering system includes a first coupler and a second coupler, which are slidably mounted with respect to one another, and which each include a pair of arms for eccentric pivotal attachment to a corresponding pair of wheel assemblies. The first and second couplers are mounted within a hollow chassis, and the wheel assemblies are mounted to the hollow chassis such that respective wheels thereof are mounted external to the hollow chassis, and respective eccentric crank arms thereof are mounted within the hollow chassis. At least one linear actuator may be provided for selectively driving sliding movement of the first coupler with respect to the second coupler.

Abstract: An eyepiece for use in front of an eye of a viewer includes a waveguide configured to propagate light therein, and a diffractive optical element optically coupled to the waveguide. The diffractive optical element includes a plurality of first ridges protruding from a surface of the waveguide. Each of the plurality of first ridges has a first height and a first width. The diffractive optical element further includes a plurality of second ridges. Each of the plurality of second ridges protrudes from a respective first ridge and has a second height greater than the first height and a second width less than the first width. The diffractive optical element is configured to diffract a portion of a light beam incident on the diffractive optical element toward the eye as a first order transmission.

Abstract: The rotation-actuated drum brake uses both inner and outer sets of brake shoes, which are actuated in a radial manner, to contact the inner and outer surfaces of a cylindrical brake drum. The inner and outer sets of brake shoes are disposed within an annular brake housing and are constrained to move radially. An actuator selectively drives rotation of a rotating disc having a plurality of arcuate slots defined therein. This drives roller guides of the inner and outer sets of brake shoes to roll within respective ones of the arcuate slots. The driven rolling of the roller guides drives the radial motion of the inner and outer sets of brake shoes to simultaneously frictionally engage the inner and outer surfaces of the cylindrical brake drum.

Abstract: An eyepiece and waveguide for viewing a projected image in a virtual reality and augmented reality imaging and visualization system. The waveguide may include a substrate for guiding light. The waveguide may also include an incoupling diffractive element disposed within or on the substrate and configured to diffract an incoupled light related to the projected image into the substrate. The waveguide may further include a first grating disposed within or on the substrate and configured to manipulate the diffracted incoupled light from the incoupling diffractive element so as to multiply the projected image and to direct the multiplied projected image to a second grating. The second grating may be disposed within or on the substrate and may be configured to outcouple the manipulated diffracted incoupled light from the waveguide. The first grating and the second grating may occupy a same region of the waveguide.

Abstract: The mobile work station with versatile tool handler arm is a mobile work station that carries a tool handler arm that can manipulate a tool in multiple global degrees of freedom. The work station has a base housing mounted on a plurality of wheels. A vertical post is mounted on top of the base housing, the vertical post having relative rotation to the base housing. An elongate tool handler arm is pivotally mounted medially at the top of the vertical post, the tool handler arm being defined by a 4-bar linkage including an upper link, a lower link, and front and rear crank blocks pin-jointed together. An elongate handlebar connected to the rear end of the tool provides control of the tool handler, and a tool carrier attached to the front end allows selective attachment of any one of a variety of tools.

Abstract: The multiple small pitch helical drives in linear and rotary actuators uses a plurality of small pitch helical screws in place of a single large pitch lead screw to provide increased power or force in a linear actuator or increased torque in a rotary actuator. The multiple small pitch helical drive includes a plurality of screws disposed between a base panel and a rear panel in a rigid skeleton, the screws having a single degree of freedom, i.e., they are free to rotate, but cannot move axially. A piston head having spaced disks includes floating nuts disposed in sockets on the disks for each of the screws, the piston head being free to travel on the screws between the base panel and the rear panel as the screws are rotated. The helical pitch reduction provided results in increased force output and increased torque for linear and rotary actuators.

Abstract: The scissor lift includes a horizontally collapsible base, a vertically collapsible frame mounted on the base, a horizontally foldable platform mounted on top of the vertically collapsible frame, and a plurality of wheels mounted on the base. The horizontally and vertically collapsible scissor lift is steerable and the plurality of wheels may be coupled such that they each rotate about a vertical axis synchronously with respect to one another to steer the lift. Further, at least one of the wheels may be self-driving to controllably propel the horizontally and vertically collapsible scissor lift. One or more winches with associated cables may be used to selectively raise and lower the vertically collapsible frame.

Abstract: An eyepiece for use in front of an eye of a viewer includes a waveguide configured to propagate light therein, and a diffractive optical element optically coupled to the waveguide. The diffractive optical element includes a plurality of first ridges protruding from a surface of the waveguide. Each of the plurality of first ridges has a first height and a first width. The diffractive optical element further includes a plurality of second ridges. Each of the plurality of second ridges protrudes from a respective first ridge and has a second height greater than the first height and a second width less than the first width. The diffractive optical element is configured to diffract a portion of a light beam incident on the diffractive optical element toward the eye as a first order transmission.

Abstract: The linear-to-rotary actuator is a device that has two rotors at opposite ends of a main housing tube, the rotors being driven to rotate by a slider disposed between the rotors, the slider being attached to the piston of a linear actuator. The device may be configured so that angular displacement between the rotors may be adjusted for use with apparatus that may require variable angular displacement between articulated segments, such as a robotic arm, the arm of an excavator or crane, and the like. In one embodiment, the device has rollers mounted on opposite sides of the slider that engage tracks defined in adaptors selectively coupled to the rotors by “boltless” connectors. In another embodiment, the device has gear trains driven by the slider that are coupled to the rotors for multiplying angular displacement between the rotors.

Abstract: An eyepiece for use in front of an eye of a viewer includes a waveguide configured to propagate light therein, and a diffractive optical element optically coupled to the waveguide. The diffractive optical element includes a plurality of first ridges protruding from a surface of the waveguide. Each of the plurality of first ridges has a first height and a first width. The diffractive optical element further includes a plurality of second ridges. Each of the plurality of second ridges protrudes from a respective first ridge and has a second height greater than the first height and a second width less than the first width. The diffractive optical element is configured to diffract a portion of a light beam incident on the diffractive optical element toward the eye as a first order transmission.

Abstract: A device includes an input coupling grating having a first grating structure characterized by a first set of grating parameters. The input coupling grating is configured to receive light from a light source. The device also includes an expansion grating having a second grating structure characterized by a second set of grating parameters varying in at least two dimensions. The second grating structure is configured to receive light from the input coupling grating. The device further includes an output coupling grating having a third grating structure characterized by a third set of grating parameters. The output coupling grating is configured to receive light from the expansion grating and to output light to a viewer.

Abstract: We have developed a model system of HIV reservoirs in neural cells by generating chimeric phosphorothioate-modified oligodeoxynucleotides (sODN) that specifically interact with neural cell DNA or RNA, and that further comprise a sequence of the HIV genome. In particular, we have conjugated the chimera sODN to a delivery vehicle (e.g. a superparamagnetic iron oxide nanoparticle (SPIO)) and have demonstrated specific delivery to neural cells, in vitro and in vivo. These model systems can be used to screen for agents that specifically target latent viral infection. In particular, using the model system, we have developed suicide MRI contrast agents that can be used to reduce the number of neural cells which harbor the virus, also provided herein. Our model system is translatable to other latent viruses as well.